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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KNTC1
Full Name:
Kinetochore-associated protein 1
Alias:
Rough deal homologue
Type:
Mass (Da):
250731
Number AA:
2209
UniProt ID:
P50748
International Prot ID:
IPI00001458
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000776
GO:0000777
GO:0000922
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000075
GO:0006461
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
W
N
D
I
E
L
L
T
N
D
D
T
G
S
G
Site 2
T13
E
L
L
T
N
D
D
T
G
S
G
Y
L
S
V
Site 3
S15
L
T
N
D
D
T
G
S
G
Y
L
S
V
G
S
Site 4
Y17
N
D
D
T
G
S
G
Y
L
S
V
G
S
R
K
Site 5
S19
D
T
G
S
G
Y
L
S
V
G
S
R
K
E
H
Site 6
S22
S
G
Y
L
S
V
G
S
R
K
E
H
G
T
A
Site 7
T28
G
S
R
K
E
H
G
T
A
L
Y
Q
V
D
L
Site 8
Y31
K
E
H
G
T
A
L
Y
Q
V
D
L
L
V
K
Site 9
S41
D
L
L
V
K
I
S
S
E
K
A
S
L
N
P
Site 10
S45
K
I
S
S
E
K
A
S
L
N
P
K
I
Q
A
Site 11
T135
A
N
D
E
N
R
R
T
Y
Q
N
L
V
I
E
Site 12
Y136
N
D
E
N
R
R
T
Y
Q
N
L
V
I
E
K
Site 13
S146
L
V
I
E
K
D
G
S
N
E
G
T
Y
Y
M
Site 14
T150
K
D
G
S
N
E
G
T
Y
Y
M
L
L
L
T
Site 15
Y151
D
G
S
N
E
G
T
Y
Y
M
L
L
L
T
Y
Site 16
Y152
G
S
N
E
G
T
Y
Y
M
L
L
L
T
Y
S
Site 17
S182
A
I
E
N
V
D
F
S
T
A
K
K
L
Q
G
Site 18
S193
K
L
Q
G
Q
I
K
S
S
F
I
S
T
E
N
Site 19
S194
L
Q
G
Q
I
K
S
S
F
I
S
T
E
N
Y
Site 20
S197
Q
I
K
S
S
F
I
S
T
E
N
Y
H
T
L
Site 21
T198
I
K
S
S
F
I
S
T
E
N
Y
H
T
L
G
Site 22
Y201
S
F
I
S
T
E
N
Y
H
T
L
G
C
L
S
Site 23
S231
G
T
G
N
C
A
F
S
K
W
E
P
D
S
S
Site 24
S237
F
S
K
W
E
P
D
S
S
K
K
G
M
T
V
Site 25
S238
S
K
W
E
P
D
S
S
K
K
G
M
T
V
K
Site 26
T300
H
V
E
E
F
L
L
T
T
E
A
D
S
P
S
Site 27
T301
V
E
E
F
L
L
T
T
E
A
D
S
P
S
S
Site 28
S305
L
L
T
T
E
A
D
S
P
S
S
V
T
W
Q
Site 29
S307
T
T
E
A
D
S
P
S
S
V
T
W
Q
G
I
Site 30
S308
T
E
A
D
S
P
S
S
V
T
W
Q
G
I
T
Site 31
T323
N
L
K
L
I
A
L
T
A
S
A
N
K
K
M
Site 32
S325
K
L
I
A
L
T
A
S
A
N
K
K
M
K
N
Site 33
S379
C
K
N
D
P
K
L
S
E
D
S
V
S
V
L
Site 34
S382
D
P
K
L
S
E
D
S
V
S
V
L
V
L
R
Site 35
S401
A
L
P
E
N
R
L
S
R
L
L
H
K
H
R
Site 36
Y427
G
L
D
V
E
L
V
Y
K
V
K
S
N
H
I
Site 37
S441
I
L
E
K
L
A
L
S
S
V
D
A
S
E
Q
Site 38
S442
L
E
K
L
A
L
S
S
V
D
A
S
E
Q
T
Site 39
S446
A
L
S
S
V
D
A
S
E
Q
T
E
W
Q
Q
Site 40
Y483
L
K
A
Q
W
I
T
Y
E
T
T
Q
E
M
L
Site 41
Y492
T
T
Q
E
M
L
N
Y
A
K
T
R
L
L
K
Site 42
T495
E
M
L
N
Y
A
K
T
R
L
L
K
K
E
D
Site 43
T504
L
L
K
K
E
D
K
T
A
L
I
Y
S
D
G
Site 44
T524
R
A
H
A
K
L
T
T
F
Y
G
A
F
G
P
Site 45
Y526
H
A
K
L
T
T
F
Y
G
A
F
G
P
E
K
Site 46
S535
A
F
G
P
E
K
F
S
G
S
S
W
I
E
F
Site 47
S538
P
E
K
F
S
G
S
S
W
I
E
F
L
N
N
Site 48
Y566
G
N
L
V
C
A
Q
Y
L
W
L
R
H
R
A
Site 49
S577
R
H
R
A
N
F
E
S
R
F
D
V
K
M
L
Site 50
S592
E
S
L
L
N
S
M
S
A
S
V
S
L
Q
K
Site 51
S596
N
S
M
S
A
S
V
S
L
Q
K
L
C
P
W
Site 52
T637
A
A
R
N
L
E
L
T
D
K
A
N
W
P
E
Site 53
T655
Q
L
A
E
I
F
F
T
A
E
K
T
D
E
L
Site 54
S667
D
E
L
G
L
A
S
S
W
H
W
I
S
L
K
Site 55
Y676
H
W
I
S
L
K
D
Y
Q
N
T
E
E
V
C
Site 56
T697
N
N
L
R
E
L
I
T
L
H
R
K
Y
N
C
Site 57
S709
Y
N
C
K
L
A
L
S
D
F
E
K
E
N
T
Site 58
T716
S
D
F
E
K
E
N
T
T
T
I
V
F
R
M
Site 59
S735
L
A
P
E
L
I
P
S
I
L
E
K
F
I
R
Site 60
Y744
L
E
K
F
I
R
V
Y
M
R
E
H
D
L
Q
Site 61
Y759
E
E
E
L
L
L
L
Y
I
E
D
L
L
N
R
Site 62
S768
E
D
L
L
N
R
C
S
S
K
S
T
S
L
F
Site 63
S769
D
L
L
N
R
C
S
S
K
S
T
S
L
F
E
Site 64
S771
L
N
R
C
S
S
K
S
T
S
L
F
E
T
A
Site 65
T772
N
R
C
S
S
K
S
T
S
L
F
E
T
A
W
Site 66
S773
R
C
S
S
K
S
T
S
L
F
E
T
A
W
E
Site 67
T777
K
S
T
S
L
F
E
T
A
W
E
A
K
A
M
Site 68
Y849
M
K
K
L
L
R
G
Y
G
I
R
E
V
N
L
Site 69
S876
L
K
Q
D
V
P
S
S
L
E
D
A
L
K
V
Site 70
T926
P
P
A
E
A
E
K
T
A
E
R
V
I
I
W
Site 71
S945
L
Q
E
E
P
D
H
S
K
E
G
K
A
W
R
Site 72
S954
E
G
K
A
W
R
M
S
V
A
K
T
S
V
D
Site 73
S1002
E
N
F
E
V
F
L
S
F
E
D
Y
S
N
S
Site 74
S1007
F
L
S
F
E
D
Y
S
N
S
S
L
V
A
D
Site 75
S1009
S
F
E
D
Y
S
N
S
S
L
V
A
D
L
R
Site 76
S1010
F
E
D
Y
S
N
S
S
L
V
A
D
L
R
E
Site 77
S1034
Q
A
K
H
K
P
G
S
T
P
E
P
I
A
A
Site 78
T1035
A
K
H
K
P
G
S
T
P
E
P
I
A
A
E
Site 79
S1045
P
I
A
A
E
V
R
S
P
S
M
E
S
K
L
Site 80
S1047
A
A
E
V
R
S
P
S
M
E
S
K
L
H
R
Site 81
T1071
Q
E
L
E
A
E
L
T
L
R
A
L
K
D
G
Site 82
T1082
L
K
D
G
N
I
K
T
A
L
K
K
C
S
D
Site 83
Y1093
K
C
S
D
L
F
K
Y
H
C
N
A
D
T
G
Site 84
S1180
C
G
I
L
M
K
A
S
F
G
T
H
K
D
P
Site 85
Y1188
F
G
T
H
K
D
P
Y
E
E
W
S
Y
S
D
Site 86
S1192
K
D
P
Y
E
E
W
S
Y
S
D
F
F
S
E
Site 87
Y1193
D
P
Y
E
E
W
S
Y
S
D
F
F
S
E
D
Site 88
S1194
P
Y
E
E
W
S
Y
S
D
F
F
S
E
D
G
Site 89
S1198
W
S
Y
S
D
F
F
S
E
D
G
I
V
L
E
Site 90
S1226
S
L
V
P
L
A
E
S
K
R
Y
P
L
E
S
Site 91
Y1229
P
L
A
E
S
K
R
Y
P
L
E
S
T
S
L
Site 92
S1233
S
K
R
Y
P
L
E
S
T
S
L
P
Y
C
S
Site 93
S1235
R
Y
P
L
E
S
T
S
L
P
Y
C
S
L
N
Site 94
S1240
S
T
S
L
P
Y
C
S
L
N
E
G
D
G
L
Site 95
S1296
N
F
M
N
A
T
L
S
E
K
L
F
G
E
T
Site 96
T1304
E
K
L
F
G
E
T
T
L
V
K
S
R
H
V
Site 97
S1308
G
E
T
T
L
V
K
S
R
H
V
V
M
E
L
Site 98
T1329
F
I
R
E
N
A
T
T
L
L
H
K
V
F
N
Site 99
Y1389
G
S
E
L
A
S
L
Y
Q
E
I
E
M
G
L
Site 100
S1402
G
L
K
F
R
E
L
S
T
D
A
Q
W
G
I
Site 101
S1417
R
L
G
K
L
G
I
S
F
Q
P
V
F
R
Q
Site 102
T1428
V
F
R
Q
H
F
L
T
K
K
D
L
I
K
A
Site 103
S1483
G
Q
G
Q
G
D
A
S
M
D
S
A
K
R
R
Site 104
S1486
Q
G
D
A
S
M
D
S
A
K
R
R
H
P
K
Site 105
Y1525
I
L
H
K
L
D
P
Y
D
Y
E
M
I
E
V
Site 106
Y1527
H
K
L
D
P
Y
D
Y
E
M
I
E
V
V
L
Site 107
T1545
E
R
A
D
E
K
I
T
N
I
N
I
N
Q
A
Site 108
S1561
S
I
L
K
H
L
K
S
Y
R
R
I
S
P
P
Site 109
Y1562
I
L
K
H
L
K
S
Y
R
R
I
S
P
P
V
Site 110
S1566
L
K
S
Y
R
R
I
S
P
P
V
D
L
E
Y
Site 111
Y1573
S
P
P
V
D
L
E
Y
Q
Y
M
L
E
H
V
Site 112
S1609
Q
N
F
W
K
I
L
S
T
E
L
S
E
E
S
Site 113
S1613
K
I
L
S
T
E
L
S
E
E
S
F
P
T
L
Site 114
S1630
I
S
K
L
M
K
F
S
L
D
T
L
Y
V
S
Site 115
T1633
L
M
K
F
S
L
D
T
L
Y
V
S
T
A
K
Site 116
Y1635
K
F
S
L
D
T
L
Y
V
S
T
A
K
H
V
Site 117
T1655
K
P
K
L
L
K
L
T
Q
A
K
S
S
T
L
Site 118
S1659
L
K
L
T
Q
A
K
S
S
T
L
I
N
K
E
Site 119
S1660
K
L
T
Q
A
K
S
S
T
L
I
N
K
E
I
Site 120
T1661
L
T
Q
A
K
S
S
T
L
I
N
K
E
I
T
Site 121
S1702
A
Q
D
I
P
E
G
S
F
K
I
S
A
L
K
Site 122
S1724
R
W
L
Q
N
I
P
S
Q
D
E
K
R
E
K
Site 123
Y1743
L
K
K
L
H
I
Q
Y
R
R
S
G
T
E
A
Site 124
S1746
L
H
I
Q
Y
R
R
S
G
T
E
A
V
L
I
Site 125
T1748
I
Q
Y
R
R
S
G
T
E
A
V
L
I
A
H
Site 126
Y1762
H
K
L
N
T
E
E
Y
L
R
V
I
G
K
P
Site 127
Y1777
A
H
L
I
V
S
L
Y
E
H
P
S
I
N
Q
Site 128
S1781
V
S
L
Y
E
H
P
S
I
N
Q
R
I
Q
N
Site 129
S1790
N
Q
R
I
Q
N
S
S
G
T
D
Y
P
D
I
Site 130
Y1794
Q
N
S
S
G
T
D
Y
P
D
I
H
A
A
A
Site 131
T1828
E
K
W
L
C
P
S
T
K
P
G
E
K
P
S
Site 132
S1835
T
K
P
G
E
K
P
S
E
L
F
E
L
Q
E
Site 133
S1855
R
V
Q
Y
L
L
L
S
R
P
I
D
Y
S
S
Site 134
T1882
T
L
G
M
H
Q
L
T
F
A
H
R
T
R
A
Site 135
T1901
F
Y
L
A
D
K
E
T
I
E
S
L
F
K
K
Site 136
S1904
A
D
K
E
T
I
E
S
L
F
K
K
P
I
E
Site 137
S1915
K
P
I
E
E
V
K
S
Y
L
R
C
I
T
F
Site 138
S1941
T
Y
E
L
F
C
S
S
P
K
E
G
M
I
K
Site 139
S1955
K
G
L
W
K
N
H
S
H
E
S
M
A
V
R
Site 140
Y1974
L
C
L
E
Y
K
I
Y
D
L
Q
L
W
N
G
Site 141
Y1994
L
G
F
N
M
I
P
Y
L
R
K
V
L
K
A
Site 142
S2003
R
K
V
L
K
A
I
S
S
I
H
S
L
W
Q
Site 143
S2030
Q
I
P
L
L
S
A
S
C
P
L
S
P
D
Q
Site 144
S2034
L
S
A
S
C
P
L
S
P
D
Q
L
S
D
C
Site 145
S2039
P
L
S
P
D
Q
L
S
D
C
S
E
S
L
I
Site 146
T2114
Q
L
E
E
H
M
N
T
G
Q
L
A
G
F
S
Site 147
T2144
E
F
G
I
L
A
K
T
K
Y
F
Q
M
L
K
Site 148
Y2146
G
I
L
A
K
T
K
Y
F
Q
M
L
K
M
H
Site 149
T2181
D
E
A
S
V
L
I
T
E
Y
S
K
H
C
G
Site 150
S2184
S
V
L
I
T
E
Y
S
K
H
C
G
K
P
V
Site 151
T2195
G
K
P
V
P
P
D
T
A
P
C
E
I
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation