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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HLCS
Full Name:
Biotin--protein ligase
Alias:
biotin apo-protein ligase: biotin-[methylmalonyl-CoA-carboxytransferase] ligase); biotin-[acetyl-CoA-carboxylase] ligase; biotin-[methylcrotonoyl-CoA-carboxylase] ligase; Biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; biotin-proprionyl-Coenzyme A-carboxylase ligase; biotin-protein ligase; BPL1; HCS; HCS); holocarboxylase synthetase; holocarboxylase synthetase (biotin-(proprionyl-coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
Type:
EC 6.3.4.10; EC 6.3.4.11; Ligase; EC 6.3.4.15; EC 6.3.4.-; Cofactor and Vitamin Metabolism - biotin; Mitochondrial; EC 6.3.4.9
Mass (Da):
80760
Number AA:
UniProt ID:
P50747
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005829
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0009374
GO:0004077
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0016570
GO:0009305
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
S
V
H
L
Q
D
S
T
L
K
E
V
K
D
Q
Site 2
S48
L
E
P
K
P
E
P
S
L
E
I
K
P
E
Q
Site 3
S79
E
P
K
Q
R
R
G
S
A
S
G
S
E
P
A
Site 4
S81
K
Q
R
R
G
S
A
S
G
S
E
P
A
G
D
Site 5
S83
R
R
G
S
A
S
G
S
E
P
A
G
D
S
D
Site 6
S89
G
S
E
P
A
G
D
S
D
R
G
G
G
P
V
Site 7
Y99
G
G
G
P
V
E
H
Y
H
L
H
L
S
S
C
Site 8
S115
E
C
L
E
L
E
N
S
T
I
E
S
V
K
F
Site 9
S119
L
E
N
S
T
I
E
S
V
K
F
A
S
A
E
Site 10
S124
I
E
S
V
K
F
A
S
A
E
N
I
P
D
L
Site 11
Y133
E
N
I
P
D
L
P
Y
D
Y
S
S
S
L
E
Site 12
Y135
I
P
D
L
P
Y
D
Y
S
S
S
L
E
S
V
Site 13
S136
P
D
L
P
Y
D
Y
S
S
S
L
E
S
V
A
Site 14
S137
D
L
P
Y
D
Y
S
S
S
L
E
S
V
A
D
Site 15
S138
L
P
Y
D
Y
S
S
S
L
E
S
V
A
D
E
Site 16
S141
D
Y
S
S
S
L
E
S
V
A
D
E
T
S
P
Site 17
T146
L
E
S
V
A
D
E
T
S
P
E
R
E
G
R
Site 18
S147
E
S
V
A
D
E
T
S
P
E
R
E
G
R
R
Site 19
T158
E
G
R
R
V
N
L
T
G
K
A
P
N
I
L
Site 20
Y167
K
A
P
N
I
L
L
Y
V
G
S
D
S
Q
E
Site 21
S172
L
L
Y
V
G
S
D
S
Q
E
A
L
G
R
F
Site 22
Y198
D
I
D
S
Y
I
L
Y
H
L
L
E
D
S
A
Site 23
S204
L
Y
H
L
L
E
D
S
A
L
R
D
P
W
T
Site 24
S224
L
V
I
A
T
R
E
S
I
P
E
D
L
Y
Q
Site 25
Y230
E
S
I
P
E
D
L
Y
Q
K
F
M
A
Y
L
Site 26
Y236
L
Y
Q
K
F
M
A
Y
L
S
Q
G
G
K
V
Site 27
S238
Q
K
F
M
A
Y
L
S
Q
G
G
K
V
L
G
Site 28
S259
F
G
G
F
Q
V
T
S
K
G
A
L
H
K
T
Site 29
T266
S
K
G
A
L
H
K
T
V
Q
N
L
V
F
S
Site 30
S273
T
V
Q
N
L
V
F
S
K
A
D
Q
S
E
V
Site 31
S283
D
Q
S
E
V
K
L
S
V
L
S
S
G
C
R
Site 32
S287
V
K
L
S
V
L
S
S
G
C
R
Y
Q
E
G
Site 33
Y291
V
L
S
S
G
C
R
Y
Q
E
G
P
V
R
L
Site 34
S299
Q
E
G
P
V
R
L
S
P
G
R
L
Q
G
H
Site 35
S340
V
H
L
E
L
P
P
S
S
N
I
V
Q
T
P
Site 36
S341
H
L
E
L
P
P
S
S
N
I
V
Q
T
P
E
Site 37
T346
P
S
S
N
I
V
Q
T
P
E
D
F
N
L
L
Site 38
S355
E
D
F
N
L
L
K
S
S
N
F
R
R
Y
E
Site 39
S356
D
F
N
L
L
K
S
S
N
F
R
R
Y
E
V
Site 40
Y361
K
S
S
N
F
R
R
Y
E
V
L
R
E
I
L
Site 41
S415
D
S
E
G
E
I
K
S
G
Q
L
S
L
R
F
Site 42
S419
E
I
K
S
G
Q
L
S
L
R
F
V
S
S
Y
Site 43
S424
Q
L
S
L
R
F
V
S
S
Y
V
S
E
V
E
Site 44
S428
R
F
V
S
S
Y
V
S
E
V
E
I
T
P
S
Site 45
S448
T
N
M
E
A
F
S
S
E
H
F
N
L
E
I
Site 46
T503
I
V
I
A
A
R
Q
T
E
G
K
G
R
G
G
Site 47
Y559
A
V
R
S
I
P
E
Y
Q
D
I
N
L
R
V
Site 48
Y573
V
K
W
P
N
D
I
Y
Y
S
D
L
M
K
I
Site 49
Y574
K
W
P
N
D
I
Y
Y
S
D
L
M
K
I
G
Site 50
S658
F
Q
D
K
G
P
N
S
V
L
P
L
Y
Y
R
Site 51
Y663
P
N
S
V
L
P
L
Y
Y
R
Y
W
V
H
S
Site 52
Y666
V
L
P
L
Y
Y
R
Y
W
V
H
S
G
Q
Q
Site 53
S685
S
A
E
G
P
K
V
S
I
V
G
L
D
D
S
Site 54
T706
Q
E
G
G
E
V
V
T
V
H
P
D
G
N
S
Site 55
S713
T
V
H
P
D
G
N
S
F
D
M
L
R
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation