KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LIG4
Full Name:
DNA ligase 4
Alias:
DNA joinase; DNA ligase IV; DNA repair enzyme; DNL4; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
Type:
EC 6.5.1.1; Ligase
Mass (Da):
103971
Number AA:
911
UniProt ID:
P49917
International Prot ID:
IPI00217669
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032807
GO:0005958
GO:0000793
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003910
PhosphoSite+
KinaseNET
Biological Process:
GO:0051102
GO:0051103
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
S
Q
T
S
Q
T
V
A
S
H
V
Site 2
T9
A
A
S
Q
T
S
Q
T
V
A
S
H
V
P
F
Site 3
T22
P
F
A
D
L
C
S
T
L
E
R
I
Q
K
S
Site 4
S29
T
L
E
R
I
Q
K
S
K
G
R
A
E
K
I
Site 5
S63
N
H
K
D
V
T
D
S
F
Y
P
A
M
R
L
Site 6
Y82
L
E
R
E
R
M
A
Y
G
I
K
E
T
M
L
Site 7
Y112
D
A
L
K
L
L
N
Y
R
T
P
T
G
T
H
Site 8
T114
L
K
L
L
N
Y
R
T
P
T
G
T
H
G
D
Site 9
T116
L
L
N
Y
R
T
P
T
G
T
H
G
D
A
G
Site 10
T118
N
Y
R
T
P
T
G
T
H
G
D
A
G
D
F
Site 11
S154
Q
V
N
D
L
L
D
S
I
A
S
N
N
S
A
Site 12
S170
R
K
D
L
I
K
K
S
L
L
Q
L
I
T
Q
Site 13
T176
K
S
L
L
Q
L
I
T
Q
S
S
A
L
E
Q
Site 14
S199
K
D
L
K
L
G
V
S
Q
Q
T
I
F
S
V
Site 15
S232
C
R
Q
L
H
D
P
S
V
G
L
S
D
I
S
Site 16
S267
E
K
D
M
K
H
Q
S
F
Y
I
E
T
K
L
Site 17
Y269
D
M
K
H
Q
S
F
Y
I
E
T
K
L
D
G
Site 18
Y288
M
H
K
D
G
D
V
Y
K
Y
F
S
R
N
G
Site 19
Y290
K
D
G
D
V
Y
K
Y
F
S
R
N
G
Y
N
Site 20
Y296
K
Y
F
S
R
N
G
Y
N
Y
T
D
Q
F
G
Site 21
Y298
F
S
R
N
G
Y
N
Y
T
D
Q
F
G
A
S
Site 22
S305
Y
T
D
Q
F
G
A
S
P
T
E
G
S
L
T
Site 23
S310
G
A
S
P
T
E
G
S
L
T
P
F
I
H
N
Site 24
T312
S
P
T
E
G
S
L
T
P
F
I
H
N
A
F
Site 25
Y335
L
D
G
E
M
M
A
Y
N
P
N
T
Q
T
F
Site 26
T341
A
Y
N
P
N
T
Q
T
F
M
Q
K
G
T
K
Site 27
T347
Q
T
F
M
Q
K
G
T
K
F
D
I
K
R
M
Site 28
T381
N
K
K
L
G
H
E
T
L
R
K
R
Y
E
I
Site 29
Y386
H
E
T
L
R
K
R
Y
E
I
L
S
S
I
F
Site 30
S390
R
K
R
Y
E
I
L
S
S
I
F
T
P
I
P
Site 31
S391
K
R
Y
E
I
L
S
S
I
F
T
P
I
P
G
Site 32
S436
I
M
V
K
Q
P
L
S
I
Y
K
P
D
K
R
Site 33
Y454
W
L
K
I
K
P
E
Y
V
S
G
L
M
D
E
Site 34
Y470
D
I
L
I
V
G
G
Y
W
G
K
G
S
R
G
Site 35
S498
P
P
P
G
E
K
P
S
V
F
H
T
L
S
R
Site 36
T502
E
K
P
S
V
F
H
T
L
S
R
V
G
S
G
Site 37
S508
H
T
L
S
R
V
G
S
G
C
T
M
K
E
L
Site 38
Y525
L
G
L
K
L
A
K
Y
W
K
P
F
H
R
K
Site 39
S536
F
H
R
K
A
P
P
S
S
I
L
C
G
T
E
Site 40
S537
H
R
K
A
P
P
S
S
I
L
C
G
T
E
K
Site 41
T542
P
S
S
I
L
C
G
T
E
K
P
E
V
Y
I
Site 42
Y548
G
T
E
K
P
E
V
Y
I
E
P
C
N
S
V
Site 43
S567
K
A
A
E
I
V
P
S
D
M
Y
K
T
G
C
Site 44
Y570
E
I
V
P
S
D
M
Y
K
T
G
C
T
L
R
Site 45
S607
E
Q
L
R
G
K
A
S
G
K
L
A
S
K
H
Site 46
Y616
K
L
A
S
K
H
L
Y
I
G
G
D
D
E
P
Site 47
T650
H
L
K
A
P
N
L
T
N
V
N
K
I
S
N
Site 48
S668
D
V
E
F
C
V
M
S
G
T
D
S
Q
P
K
Site 49
S672
C
V
M
S
G
T
D
S
Q
P
K
P
D
L
E
Site 50
Y688
R
I
A
E
F
G
G
Y
I
V
Q
N
P
G
P
Site 51
T697
V
Q
N
P
G
P
D
T
Y
C
V
I
A
G
S
Site 52
Y698
Q
N
P
G
P
D
T
Y
C
V
I
A
G
S
E
Site 53
Y758
K
E
H
F
A
R
E
Y
D
C
Y
G
D
S
Y
Site 54
Y761
F
A
R
E
Y
D
C
Y
G
D
S
Y
F
I
D
Site 55
Y765
Y
D
C
Y
G
D
S
Y
F
I
D
T
D
L
N
Site 56
T769
G
D
S
Y
F
I
D
T
D
L
N
Q
L
K
E
Site 57
S779
N
Q
L
K
E
V
F
S
G
I
K
N
S
N
E
Site 58
S784
V
F
S
G
I
K
N
S
N
E
Q
T
P
E
E
Site 59
T788
I
K
N
S
N
E
Q
T
P
E
E
M
A
S
L
Site 60
S794
Q
T
P
E
E
M
A
S
L
I
A
D
L
E
Y
Site 61
Y801
S
L
I
A
D
L
E
Y
R
Y
S
W
D
C
S
Site 62
S804
A
D
L
E
Y
R
Y
S
W
D
C
S
P
L
S
Site 63
T817
L
S
M
F
R
R
H
T
V
Y
L
D
S
Y
A
Site 64
S822
R
H
T
V
Y
L
D
S
Y
A
V
I
N
D
L
Site 65
S830
Y
A
V
I
N
D
L
S
T
K
N
E
G
T
R
Site 66
S870
V
I
I
G
E
D
H
S
R
V
A
D
F
K
A
Site 67
T881
D
F
K
A
F
R
R
T
F
K
R
K
F
K
I
Site 68
S892
K
F
K
I
L
K
E
S
W
V
T
D
S
I
D
Site 69
T895
I
L
K
E
S
W
V
T
D
S
I
D
K
C
E
Site 70
S897
K
E
S
W
V
T
D
S
I
D
K
C
E
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation