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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTHFS
Full Name:
5-formyltetrahydrofolate cyclo-ligase
Alias:
5,10-methenyl- tetrahydrofolate synthetase; 5,10-methenyltetrahydrofolate synthetase; 5,10-methenyl-tetrahydrofolate synthetase; HsT19268; Methenyl-THF synthetase
Type:
Ligase; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 6.3.3.2
Mass (Da):
23256
Number AA:
203
UniProt ID:
P49914
International Prot ID:
IPI00220567
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0030272
GO:0005524
GO:0005542
PhosphoSite+
KinaseNET
Biological Process:
GO:0009396
GO:0015942
GO:0046653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
V
S
S
A
K
R
S
L
R
G
E
L
K
Q
Site 2
S25
K
Q
R
L
R
A
M
S
A
E
E
R
L
R
Q
Site 3
S33
A
E
E
R
L
R
Q
S
R
V
L
S
Q
K
V
Site 4
S37
L
R
Q
S
R
V
L
S
Q
K
V
I
A
H
S
Site 5
Y46
K
V
I
A
H
S
E
Y
Q
K
S
K
R
I
S
Site 6
S49
A
H
S
E
Y
Q
K
S
K
R
I
S
I
F
L
Site 7
S53
Y
Q
K
S
K
R
I
S
I
F
L
S
M
Q
D
Site 8
S57
K
R
I
S
I
F
L
S
M
Q
D
E
I
E
T
Site 9
S102
I
E
S
P
E
E
I
S
L
L
P
K
T
S
W
Site 10
T107
E
I
S
L
L
P
K
T
S
W
N
I
P
Q
P
Site 11
S108
I
S
L
L
P
K
T
S
W
N
I
P
Q
P
G
Site 12
S125
D
V
R
E
E
A
L
S
T
G
G
L
D
L
I
Site 13
Y152
R
L
G
R
G
K
G
Y
Y
D
A
Y
L
K
R
Site 14
Y153
L
G
R
G
K
G
Y
Y
D
A
Y
L
K
R
C
Site 15
Y156
G
K
G
Y
Y
D
A
Y
L
K
R
C
L
Q
H
Site 16
Y169
Q
H
Q
E
V
K
P
Y
T
L
A
L
A
F
K
Site 17
Y197
M
K
V
D
E
V
L
Y
E
D
S
S
T
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation