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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAF6
Full Name:
Transcription initiation factor TFIID subunit 6
Alias:
MGC8964; TAF(II)70; TAF2E; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kD; TAFII- 80; TAFII70; TAFII-70; TAFII80; TAFII85; Transcription initiation factor TFIID 70 kD subunit; Transcription initiation factor TFIID 70 kDa subunit
Type:
Transcription protein, initiation complex
Mass (Da):
72668
Number AA:
677
UniProt ID:
P49848
International Prot ID:
IPI00028579
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005669
GO:0033276
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0016251
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0045786
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
E
K
K
L
K
L
S
N
T
V
L
P
S
E
Site 2
T12
K
K
L
K
L
S
N
T
V
L
P
S
E
S
M
Site 3
T40
E
E
T
C
Q
L
L
T
D
E
V
S
Y
R
I
Site 4
S44
Q
L
L
T
D
E
V
S
Y
R
I
K
E
I
A
Site 5
T67
M
G
K
R
Q
K
L
T
T
S
D
I
D
Y
A
Site 6
T68
G
K
R
Q
K
L
T
T
S
D
I
D
Y
A
L
Site 7
Y73
L
T
T
S
D
I
D
Y
A
L
K
L
K
N
V
Site 8
Y84
L
K
N
V
E
P
L
Y
G
F
H
A
Q
E
F
Site 9
S98
F
I
P
F
R
F
A
S
G
G
G
R
E
L
Y
Site 10
Y105
S
G
G
G
R
E
L
Y
F
Y
E
E
K
E
V
Site 11
Y107
G
G
R
E
L
Y
F
Y
E
E
K
E
V
D
L
Site 12
S115
E
E
K
E
V
D
L
S
D
I
I
N
T
P
L
Site 13
S167
E
A
T
E
P
L
K
S
A
K
P
G
Q
E
E
Site 14
S212
P
L
R
L
K
P
R
S
I
H
E
L
S
V
E
Site 15
S217
P
R
S
I
H
E
L
S
V
E
Q
Q
L
Y
Y
Site 16
Y223
L
S
V
E
Q
Q
L
Y
Y
K
E
I
T
E
A
Site 17
Y224
S
V
E
Q
Q
L
Y
Y
K
E
I
T
E
A
C
Site 18
S245
K
R
A
E
A
L
Q
S
I
A
T
D
P
G
L
Site 19
T248
E
A
L
Q
S
I
A
T
D
P
G
L
Y
Q
M
Site 20
Y253
I
A
T
D
P
G
L
Y
Q
M
L
P
R
F
S
Site 21
T261
Q
M
L
P
R
F
S
T
F
I
S
E
G
V
R
Site 22
S264
P
R
F
S
T
F
I
S
E
G
V
R
V
N
V
Site 23
Y281
N
N
L
A
L
L
I
Y
L
M
R
M
V
K
A
Site 24
T294
K
A
L
M
D
N
P
T
L
Y
L
E
K
Y
V
Site 25
Y296
L
M
D
N
P
T
L
Y
L
E
K
Y
V
H
E
Site 26
T356
N
N
I
Q
S
R
I
T
K
T
F
T
K
S
W
Site 27
T358
I
Q
S
R
I
T
K
T
F
T
K
S
W
V
D
Site 28
S362
I
T
K
T
F
T
K
S
W
V
D
E
K
T
P
Site 29
T368
K
S
W
V
D
E
K
T
P
W
T
T
R
Y
G
Site 30
T371
V
D
E
K
T
P
W
T
T
R
Y
G
S
I
A
Site 31
T372
D
E
K
T
P
W
T
T
R
Y
G
S
I
A
G
Site 32
Y374
K
T
P
W
T
T
R
Y
G
S
I
A
G
L
A
Site 33
S376
P
W
T
T
R
Y
G
S
I
A
G
L
A
E
L
Site 34
S405
Q
E
G
E
R
I
R
S
V
L
D
G
P
V
L
Site 35
S413
V
L
D
G
P
V
L
S
N
I
D
R
I
G
A
Site 36
Y448
P
P
D
N
Q
D
A
Y
R
A
E
F
G
S
L
Site 37
T481
A
Q
Q
V
N
R
T
T
L
T
I
T
Q
P
R
Site 38
T483
Q
V
N
R
T
T
L
T
I
T
Q
P
R
P
T
Site 39
T490
T
I
T
Q
P
R
P
T
L
T
L
S
Q
A
P
Site 40
T492
T
Q
P
R
P
T
L
T
L
S
Q
A
P
Q
P
Site 41
S494
P
R
P
T
L
T
L
S
Q
A
P
Q
P
G
P
Site 42
T503
A
P
Q
P
G
P
R
T
P
G
L
L
K
V
P
Site 43
S532
A
A
A
P
P
Q
P
S
P
P
P
T
K
F
I
Site 44
T536
P
Q
P
S
P
P
P
T
K
F
I
V
M
S
S
Site 45
S542
P
T
K
F
I
V
M
S
S
S
S
S
A
P
S
Site 46
S543
T
K
F
I
V
M
S
S
S
S
S
A
P
S
T
Site 47
S544
K
F
I
V
M
S
S
S
S
S
A
P
S
T
Q
Site 48
S545
F
I
V
M
S
S
S
S
S
A
P
S
T
Q
Q
Site 49
S546
I
V
M
S
S
S
S
S
A
P
S
T
Q
Q
V
Site 50
S549
S
S
S
S
S
A
P
S
T
Q
Q
V
L
S
L
Site 51
T550
S
S
S
S
A
P
S
T
Q
Q
V
L
S
L
S
Site 52
S555
P
S
T
Q
Q
V
L
S
L
S
T
S
A
P
G
Site 53
S557
T
Q
Q
V
L
S
L
S
T
S
A
P
G
S
G
Site 54
S559
Q
V
L
S
L
S
T
S
A
P
G
S
G
S
T
Site 55
S563
L
S
T
S
A
P
G
S
G
S
T
T
T
S
P
Site 56
S565
T
S
A
P
G
S
G
S
T
T
T
S
P
V
T
Site 57
T567
A
P
G
S
G
S
T
T
T
S
P
V
T
T
T
Site 58
S569
G
S
G
S
T
T
T
S
P
V
T
T
T
V
P
Site 59
T572
S
T
T
T
S
P
V
T
T
T
V
P
S
V
Q
Site 60
T573
T
T
T
S
P
V
T
T
T
V
P
S
V
Q
P
Site 61
T590
K
L
V
S
T
A
T
T
A
P
P
S
T
A
P
Site 62
S594
T
A
T
T
A
P
P
S
T
A
P
S
G
P
G
Site 63
T595
A
T
T
A
P
P
S
T
A
P
S
G
P
G
S
Site 64
S598
A
P
P
S
T
A
P
S
G
P
G
S
V
Q
K
Site 65
T622
G
E
G
K
G
G
P
T
S
H
P
S
P
V
P
Site 66
S623
E
G
K
G
G
P
T
S
H
P
S
P
V
P
P
Site 67
S626
G
G
P
T
S
H
P
S
P
V
P
P
P
A
S
Site 68
S633
S
P
V
P
P
P
A
S
S
P
S
P
L
S
G
Site 69
S634
P
V
P
P
P
A
S
S
P
S
P
L
S
G
S
Site 70
S636
P
P
P
A
S
S
P
S
P
L
S
G
S
A
L
Site 71
S641
S
P
S
P
L
S
G
S
A
L
C
G
G
K
Q
Site 72
S653
G
K
Q
E
A
G
D
S
P
P
P
A
P
G
T
Site 73
T660
S
P
P
P
A
P
G
T
P
K
A
N
G
S
Q
Site 74
S666
G
T
P
K
A
N
G
S
Q
P
N
S
G
S
P
Site 75
S670
A
N
G
S
Q
P
N
S
G
S
P
Q
P
A
P
Site 76
S672
G
S
Q
P
N
S
G
S
P
Q
P
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation