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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOT2
Full Name:
Acyl-coenzyme A thioesterase 2, mitochondrial
Alias:
Acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2; CTE-Ia; Long-chain acyl-CoA thioesterase 2; Mitochondrial acyl-CoA thioesterase 1; Mte1; Peroxisomal acyl-coenzyme A thioester hydrolase 2a; Peroxisomal long-chain acyl-coA thioesterase 2; ZAP128
Type:
Hydrolase; Mitochondrial; EC 3.1.2.2; Lipid Metabolism - unsaturated fatty acid biosynthesis
Mass (Da):
53200
Number AA:
483
UniProt ID:
P49753
International Prot ID:
IPI00220906
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0004091
GO:0016290
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006637
GO:0001676
GO:0000038
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
N
K
L
L
S
P
H
P
H
S
V
V
Site 2
S12
L
L
S
P
H
P
H
S
V
V
L
R
S
E
F
Site 3
S17
P
H
S
V
V
L
R
S
E
F
K
M
A
S
S
Site 4
S24
S
E
F
K
M
A
S
S
P
A
V
L
R
A
S
Site 5
S31
S
P
A
V
L
R
A
S
R
L
Y
Q
W
S
L
Site 6
Y34
V
L
R
A
S
R
L
Y
Q
W
S
L
K
S
S
Site 7
S37
A
S
R
L
Y
Q
W
S
L
K
S
S
A
Q
F
Site 8
S40
L
Y
Q
W
S
L
K
S
S
A
Q
F
L
G
S
Site 9
S41
Y
Q
W
S
L
K
S
S
A
Q
F
L
G
S
P
Site 10
S47
S
S
A
Q
F
L
G
S
P
Q
L
R
Q
V
G
Site 11
T66
V
P
A
R
M
A
A
T
L
I
L
E
P
A
G
Site 12
T95
L
A
P
E
Q
P
V
T
L
R
A
S
L
R
D
Site 13
S99
Q
P
V
T
L
R
A
S
L
R
D
E
K
G
A
Site 14
T118
H
A
R
Y
R
A
D
T
L
G
E
L
D
L
E
Site 15
T162
L
V
K
R
D
V
R
T
P
L
A
V
E
L
E
Site 16
T185
P
G
R
L
L
C
Q
T
R
H
E
R
Y
F
L
Site 17
Y190
C
Q
T
R
H
E
R
Y
F
L
P
P
G
V
R
Site 18
T209
R
V
G
R
V
R
G
T
L
F
L
P
P
E
P
Site 19
Y253
A
V
M
A
L
A
Y
Y
N
Y
E
D
L
P
K
Site 20
T261
N
Y
E
D
L
P
K
T
M
E
T
L
H
L
E
Site 21
Y269
M
E
T
L
H
L
E
Y
F
E
E
A
M
N
Y
Site 22
Y276
Y
F
E
E
A
M
N
Y
L
L
S
H
P
E
V
Site 23
S279
E
A
M
N
Y
L
L
S
H
P
E
V
K
G
P
Site 24
T326
S
V
A
N
V
G
G
T
L
R
Y
K
G
E
T
Site 25
T333
T
L
R
Y
K
G
E
T
L
P
P
V
G
V
N
Site 26
Y351
I
K
V
T
K
D
G
Y
A
D
I
V
D
V
L
Site 27
S360
D
I
V
D
V
L
N
S
P
L
E
G
P
D
Q
Site 28
S369
L
E
G
P
D
Q
K
S
F
I
P
V
E
R
A
Site 29
Y417
R
K
P
Q
I
I
C
Y
P
E
T
G
H
Y
I
Site 30
Y423
C
Y
P
E
T
G
H
Y
I
E
P
P
Y
F
P
Site 31
Y428
G
H
Y
I
E
P
P
Y
F
P
L
C
R
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation