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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THBS3
Full Name:
Thrombospondin-3
Alias:
TSP3
Type:
Extracellular region protein
Mass (Da):
104201
Number AA:
956
UniProt ID:
P49746
International Prot ID:
IPI00329535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T61
G
D
I
Y
L
L
S
T
F
R
L
P
P
K
Q
Site 2
Y76
G
G
V
L
F
G
L
Y
S
R
Q
D
N
T
R
Site 3
S77
G
V
L
F
G
L
Y
S
R
Q
D
N
T
R
W
Site 4
S88
N
T
R
W
L
E
A
S
V
V
G
K
I
N
K
Site 5
Y100
I
N
K
V
L
V
R
Y
Q
R
E
D
G
K
V
Site 6
T124
L
A
D
G
R
T
H
T
V
L
L
R
L
R
G
Site 7
S133
L
L
R
L
R
G
P
S
R
P
S
P
A
L
H
Site 8
S136
L
R
G
P
S
R
P
S
P
A
L
H
L
Y
V
Site 9
Y142
P
S
P
A
L
H
L
Y
V
D
C
K
L
G
D
Site 10
Y177
I
R
T
G
Q
K
A
Y
L
R
M
Q
G
F
V
Site 11
S186
R
M
Q
G
F
V
E
S
M
K
I
I
L
G
G
Site 12
S194
M
K
I
I
L
G
G
S
M
A
R
V
G
A
L
Site 13
S202
M
A
R
V
G
A
L
S
E
C
P
F
Q
G
D
Site 14
S214
Q
G
D
E
S
I
H
S
A
V
T
N
A
L
H
Site 15
T228
H
S
I
L
G
E
Q
T
K
A
L
V
T
Q
L
Site 16
S257
R
D
Q
V
K
E
M
S
L
I
R
N
T
I
M
Site 17
S279
H
E
Q
R
S
H
C
S
P
N
P
C
F
R
G
Site 18
Y293
G
V
D
C
M
E
V
Y
E
Y
P
G
Y
R
C
Site 19
Y295
D
C
M
E
V
Y
E
Y
P
G
Y
R
C
G
P
Site 20
Y298
E
V
Y
E
Y
P
G
Y
R
C
G
P
C
P
P
Site 21
T312
P
G
L
Q
G
N
G
T
H
C
S
D
I
N
E
Site 22
Y348
C
E
A
C
P
R
G
Y
K
G
T
Q
V
S
G
Site 23
T351
C
P
R
G
Y
K
G
T
Q
V
S
G
V
G
I
Site 24
S354
G
Y
K
G
T
Q
V
S
G
V
G
I
D
Y
A
Site 25
Y360
V
S
G
V
G
I
D
Y
A
R
A
S
K
Q
V
Site 26
T391
P
N
S
I
C
T
N
T
V
G
S
F
K
C
G
Site 27
S409
L
G
F
L
G
N
Q
S
Q
G
C
L
P
A
R
Site 28
T417
Q
G
C
L
P
A
R
T
C
H
S
P
A
H
S
Site 29
S420
L
P
A
R
T
C
H
S
P
A
H
S
P
C
H
Site 30
T459
G
N
V
C
G
T
D
T
D
I
D
G
Y
P
D
Site 31
Y464
T
D
T
D
I
D
G
Y
P
D
Q
A
L
P
C
Site 32
T486
K
Q
D
N
C
L
L
T
P
N
S
G
Q
E
D
Site 33
S489
N
C
L
L
T
P
N
S
G
Q
E
D
A
D
N
Site 34
S530
P
N
K
D
Q
Q
N
S
D
T
D
S
F
G
D
Site 35
T532
K
D
Q
Q
N
S
D
T
D
S
F
G
D
A
C
Site 36
S534
Q
Q
N
S
D
T
D
S
F
G
D
A
C
D
N
Site 37
T553
P
N
N
D
Q
K
D
T
D
G
N
G
E
G
D
Site 38
T587
K
V
P
N
P
L
Q
T
D
R
D
E
D
G
V
Site 39
S600
G
V
G
D
A
C
D
S
C
P
E
M
S
N
P
Site 40
T610
E
M
S
N
P
T
Q
T
D
A
D
S
D
L
V
Site 41
S614
P
T
Q
T
D
A
D
S
D
L
V
G
D
V
C
Site 42
T623
L
V
G
D
V
C
D
T
N
E
D
S
D
G
D
Site 43
S627
V
C
D
T
N
E
D
S
D
G
D
G
H
Q
D
Site 44
T635
D
G
D
G
H
Q
D
T
K
D
N
C
P
Q
L
Site 45
S645
N
C
P
Q
L
P
N
S
S
Q
L
D
S
D
N
Site 46
S646
C
P
Q
L
P
N
S
S
Q
L
D
S
D
N
D
Site 47
S650
P
N
S
S
Q
L
D
S
D
N
D
G
L
G
D
Site 48
Y671
D
N
D
G
I
P
D
Y
V
P
P
G
P
D
N
Site 49
S690
P
N
P
N
Q
K
D
S
D
G
N
G
V
G
D
Site 50
S718
P
L
D
V
C
P
E
S
A
E
V
T
L
T
D
Site 51
T722
C
P
E
S
A
E
V
T
L
T
D
F
R
A
Y
Site 52
T724
E
S
A
E
V
T
L
T
D
F
R
A
Y
Q
T
Site 53
T758
Q
G
M
E
I
V
Q
T
M
N
S
D
P
G
L
Site 54
T785
E
G
T
F
H
V
N
T
V
T
D
D
D
Y
A
Site 55
Y791
N
T
V
T
D
D
D
Y
A
G
F
L
F
S
Y
Site 56
S797
D
Y
A
G
F
L
F
S
Y
Q
D
S
G
R
F
Site 57
Y798
Y
A
G
F
L
F
S
Y
Q
D
S
G
R
F
Y
Site 58
Y805
Y
Q
D
S
G
R
F
Y
V
V
M
W
K
Q
T
Site 59
T820
E
Q
T
Y
W
Q
A
T
P
F
R
A
V
A
Q
Site 60
S837
L
Q
L
K
A
V
T
S
V
S
G
P
G
E
H
Site 61
S839
L
K
A
V
T
S
V
S
G
P
G
E
H
L
R
Site 62
T855
A
L
W
H
T
G
H
T
P
D
Q
V
R
L
L
Site 63
Y877
G
W
R
D
K
T
S
Y
R
W
Q
L
L
H
R
Site 64
Y889
L
H
R
P
Q
V
G
Y
I
R
V
K
L
Y
E
Site 65
Y895
G
Y
I
R
V
K
L
Y
E
G
P
Q
L
V
A
Site 66
T910
D
S
G
V
I
I
D
T
S
M
R
G
G
R
L
Site 67
Y934
I
I
W
S
N
L
Q
Y
R
C
N
D
T
V
P
Site 68
T939
L
Q
Y
R
C
N
D
T
V
P
E
D
F
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation