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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HARSL
Full Name:
Probable histidyl-tRNA synthetase, mitochondrial
Alias:
Gistidyl-tRNA synthetase; HARSR; HARS-related; HisRS; Histidine translase; Histidine tRNA ligase 2, mitochondrial; Histidine-tRNA ligase; Histidyl-tRNA synthetase 2, mitochondrial; Histidyl-tRNA synthetase-like; HO3; SYHM
Type:
Ligase; EC 6.1.1.21
Mass (Da):
56888
Number AA:
506
UniProt ID:
P49590
International Prot ID:
IPI00027445
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005739
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004821
GO:0004812
PhosphoSite+
KinaseNET
Biological Process:
GO:0006427
GO:0006139
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
P
R
R
A
W
A
S
L
L
S
Q
L
L
R
Site 2
T28
R
P
P
C
A
S
C
T
G
A
V
R
C
Q
S
Site 3
T43
Q
V
A
E
A
V
L
T
S
Q
L
K
A
H
Q
Site 4
T59
K
P
N
F
I
I
K
T
P
K
G
T
R
D
L
Site 5
T63
I
I
K
T
P
K
G
T
R
D
L
S
P
Q
H
Site 6
S67
P
K
G
T
R
D
L
S
P
Q
H
M
V
V
R
Site 7
T95
H
G
A
K
G
M
D
T
P
A
F
E
L
K
E
Site 8
T103
P
A
F
E
L
K
E
T
L
T
E
K
Y
G
E
Site 9
Y108
K
E
T
L
T
E
K
Y
G
E
D
S
G
L
M
Site 10
Y116
G
E
D
S
G
L
M
Y
D
L
K
D
Q
G
G
Site 11
S127
D
Q
G
G
E
L
L
S
L
R
Y
D
L
T
V
Site 12
Y151
K
V
K
K
M
K
R
Y
H
V
G
K
V
W
R
Site 13
S161
G
K
V
W
R
R
E
S
P
T
I
V
Q
G
R
Site 14
T163
V
W
R
R
E
S
P
T
I
V
Q
G
R
Y
R
Site 15
S237
S
K
F
R
A
I
C
S
S
I
D
K
L
D
K
Site 16
S238
K
F
R
A
I
C
S
S
I
D
K
L
D
K
M
Site 17
S291
M
F
Q
D
P
R
L
S
Q
N
K
Q
A
L
E
Site 18
S324
D
K
I
S
F
D
L
S
L
A
R
G
L
D
Y
Site 19
Y331
S
L
A
R
G
L
D
Y
Y
T
G
V
I
Y
E
Site 20
T344
Y
E
A
V
L
L
Q
T
P
T
Q
A
G
E
E
Site 21
S357
E
E
P
L
N
V
G
S
V
A
A
G
G
R
Y
Site 22
Y364
S
V
A
A
G
G
R
Y
D
G
L
V
G
M
F
Site 23
T400
I
V
E
Q
R
M
K
T
K
G
E
K
V
R
T
Site 24
T407
T
K
G
E
K
V
R
T
T
E
T
Q
V
F
V
Site 25
T408
K
G
E
K
V
R
T
T
E
T
Q
V
F
V
A
Site 26
T410
E
K
V
R
T
T
E
T
Q
V
F
V
A
T
P
Site 27
T416
E
T
Q
V
F
V
A
T
P
Q
K
N
F
L
Q
Site 28
Y443
G
I
K
A
E
M
L
Y
K
N
N
P
K
L
L
Site 29
Y455
K
L
L
T
Q
L
H
Y
C
E
S
T
G
I
P
Site 30
S481
E
G
V
I
K
I
R
S
V
A
S
R
E
E
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation