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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCYT1A
Full Name:
Choline-phosphate cytidylyltransferase A
Alias:
CCT A; CCT-alpha; Cholinephosphate cytidylyltransferase A; CT; CT A; CTP:phosphocholine cytidylyltransferase A; CTPCT; CTPT; PCY1A; PCYT1; Phosphate cytidylyltransferase 1, choline, alpha; Phosphate cytidylyltransferase 1, choline, alpha isoform; Phosphorylcholine transferase A
Type:
EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase
Mass (Da):
41731
Number AA:
367
UniProt ID:
P49585
International Prot ID:
IPI00329338
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0004105
GO:0004105
GO:0016740
PhosphoSite+
KinaseNET
Biological Process:
GO:0008654
GO:0006643
GO:0006644
Phosida
TranscriptoNet
STRING
Kinexus Products
CTP: phosphocholine cytidylyltransferase isoform A T342+S343 phosphosite-specific antibody AB-PN547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN547#CTP: phosphocholine cytidylyltransferase isoform A Y359+S362 phosphosite-specific antibody AB-PN548#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN548#CTP: phosphocholine cytidylyltransferase isoform A S329+S331 phosphosite-specific antibody AB-PN561#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN561
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
L
R
Q
P
A
P
F
S
D
E
I
E
V
D
F
Site 2
S56
D
E
I
E
V
D
F
S
K
P
Y
V
R
V
T
Site 3
Y59
E
V
D
F
S
K
P
Y
V
R
V
T
M
E
E
Site 4
T63
S
K
P
Y
V
R
V
T
M
E
E
A
S
R
G
Site 5
T71
M
E
E
A
S
R
G
T
P
C
E
R
P
V
R
Site 6
T118
G
V
C
S
D
E
L
T
H
N
F
K
G
F
T
Site 7
Y133
V
M
N
E
N
E
R
Y
D
A
V
Q
H
C
R
Site 8
Y141
D
A
V
Q
H
C
R
Y
V
D
E
V
V
R
N
Site 9
T154
R
N
A
P
W
T
L
T
P
E
F
L
A
E
H
Site 10
Y173
V
A
H
D
D
I
P
Y
S
S
A
G
S
D
D
Site 11
S174
A
H
D
D
I
P
Y
S
S
A
G
S
D
D
V
Site 12
S178
I
P
Y
S
S
A
G
S
D
D
V
Y
K
H
I
Site 13
Y182
S
A
G
S
D
D
V
Y
K
H
I
K
E
A
G
Site 14
T194
E
A
G
M
F
A
P
T
Q
R
T
E
G
I
S
Site 15
T197
M
F
A
P
T
Q
R
T
E
G
I
S
T
S
D
Site 16
S201
T
Q
R
T
E
G
I
S
T
S
D
I
I
T
R
Site 17
T202
Q
R
T
E
G
I
S
T
S
D
I
I
T
R
I
Site 18
S203
R
T
E
G
I
S
T
S
D
I
I
T
R
I
V
Site 19
T207
I
S
T
S
D
I
I
T
R
I
V
R
D
Y
D
Site 20
Y213
I
T
R
I
V
R
D
Y
D
V
Y
A
R
R
N
Site 21
Y216
I
V
R
D
Y
D
V
Y
A
R
R
N
L
Q
R
Site 22
Y225
R
R
N
L
Q
R
G
Y
T
A
K
E
L
N
V
Site 23
T226
R
N
L
Q
R
G
Y
T
A
K
E
L
N
V
S
Site 24
S233
T
A
K
E
L
N
V
S
F
I
N
E
K
K
Y
Site 25
Y240
S
F
I
N
E
K
K
Y
H
L
Q
E
R
V
D
Site 26
S260
V
K
D
V
E
E
K
S
K
E
F
V
Q
K
V
Site 27
S271
V
Q
K
V
E
E
K
S
I
D
L
I
Q
K
W
Site 28
S282
I
Q
K
W
E
E
K
S
R
E
F
I
G
S
F
Site 29
S288
K
S
R
E
F
I
G
S
F
L
E
M
F
G
P
Site 30
S315
G
R
M
L
Q
A
I
S
P
K
Q
S
P
S
S
Site 31
S319
Q
A
I
S
P
K
Q
S
P
S
S
S
P
T
R
Site 32
S321
I
S
P
K
Q
S
P
S
S
S
P
T
R
E
R
Site 33
S322
S
P
K
Q
S
P
S
S
S
P
T
R
E
R
S
Site 34
S323
P
K
Q
S
P
S
S
S
P
T
R
E
R
S
P
Site 35
T325
Q
S
P
S
S
S
P
T
R
E
R
S
P
S
P
Site 36
S329
S
S
P
T
R
E
R
S
P
S
P
S
F
R
W
CTP: phosphocholine cytidylyltransferase isoform A S329+S331 phosphosite-specific antibody AB-PN561#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN561
Site 37
S331
P
T
R
E
R
S
P
S
P
S
F
R
W
P
F
CTP: phosphocholine cytidylyltransferase isoform A S329+S331 phosphosite-specific antibody AB-PN561#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN561
Site 38
S333
R
E
R
S
P
S
P
S
F
R
W
P
F
S
G
Site 39
S339
P
S
F
R
W
P
F
S
G
K
T
S
P
P
C
Site 40
T342
R
W
P
F
S
G
K
T
S
P
P
C
S
P
A
CTP: phosphocholine cytidylyltransferase isoform A T342+S343 phosphosite-specific antibody AB-PN547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN547
Site 41
S343
W
P
F
S
G
K
T
S
P
P
C
S
P
A
N
CTP: phosphocholine cytidylyltransferase isoform A T342+S343 phosphosite-specific antibody AB-PN547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN547
Site 42
S347
G
K
T
S
P
P
C
S
P
A
N
L
S
R
H
Site 43
S352
P
C
S
P
A
N
L
S
R
H
K
A
A
A
Y
Site 44
Y359
S
R
H
K
A
A
A
Y
D
I
S
E
D
E
E
CTP: phosphocholine cytidylyltransferase isoform A Y359+S362 phosphosite-specific antibody AB-PN548#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN548
Site 45
S362
K
A
A
A
Y
D
I
S
E
D
E
E
D
_
_
CTP: phosphocholine cytidylyltransferase isoform A Y359+S362 phosphosite-specific antibody AB-PN548#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN548
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation