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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CENPF
Full Name:
Centromere protein F
Alias:
AH; Cell-cycle-dependent 350K nuclear protein; CENF; CENP-F kinetochore; Centromere protein F, 350/400ka; Hcp-1; Kinetochore protein CENP-F; Mitosin
Type:
Cell cycle regulation
Mass (Da):
367764
Number AA:
3210
UniProt ID:
P49454
International Prot ID:
IPI00027157
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030496
GO:0005635
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0045502
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0000085
GO:0030154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
Q
R
Q
F
Q
L
D
S
L
E
A
A
L
Q
K
Site 2
T60
Q
K
V
E
N
E
K
T
E
G
T
N
L
K
R
Site 3
S78
R
L
M
E
I
C
E
S
L
E
K
T
K
Q
K
Site 4
T82
I
C
E
S
L
E
K
T
K
Q
K
I
S
H
E
Site 5
S95
H
E
L
Q
V
K
E
S
Q
V
N
F
Q
E
G
Site 6
S106
F
Q
E
G
Q
L
N
S
G
K
K
Q
I
E
K
Site 7
S123
Q
E
L
K
R
C
K
S
E
L
E
R
S
Q
Q
Site 8
S128
C
K
S
E
L
E
R
S
Q
Q
A
A
Q
S
A
Site 9
S134
R
S
Q
Q
A
A
Q
S
A
D
V
S
L
N
P
Site 10
S138
A
A
Q
S
A
D
V
S
L
N
P
C
N
T
P
Site 11
T144
V
S
L
N
P
C
N
T
P
Q
K
I
F
T
T
Site 12
T150
N
T
P
Q
K
I
F
T
T
P
L
T
P
S
Q
Site 13
T151
T
P
Q
K
I
F
T
T
P
L
T
P
S
Q
Y
Site 14
T154
K
I
F
T
T
P
L
T
P
S
Q
Y
Y
S
G
Site 15
S156
F
T
T
P
L
T
P
S
Q
Y
Y
S
G
S
K
Site 16
Y158
T
P
L
T
P
S
Q
Y
Y
S
G
S
K
Y
E
Site 17
Y159
P
L
T
P
S
Q
Y
Y
S
G
S
K
Y
E
D
Site 18
S160
L
T
P
S
Q
Y
Y
S
G
S
K
Y
E
D
L
Site 19
S162
P
S
Q
Y
Y
S
G
S
K
Y
E
D
L
K
E
Site 20
Y164
Q
Y
Y
S
G
S
K
Y
E
D
L
K
E
K
Y
Site 21
S213
D
I
A
R
H
Q
A
S
S
S
V
F
S
W
Q
Site 22
S214
I
A
R
H
Q
A
S
S
S
V
F
S
W
Q
Q
Site 23
S215
A
R
H
Q
A
S
S
S
V
F
S
W
Q
Q
E
Site 24
S218
Q
A
S
S
S
V
F
S
W
Q
Q
E
K
T
P
Site 25
T224
F
S
W
Q
Q
E
K
T
P
S
H
L
S
S
N
Site 26
S226
W
Q
Q
E
K
T
P
S
H
L
S
S
N
S
Q
Site 27
S229
E
K
T
P
S
H
L
S
S
N
S
Q
R
T
P
Site 28
S230
K
T
P
S
H
L
S
S
N
S
Q
R
T
P
I
Site 29
S232
P
S
H
L
S
S
N
S
Q
R
T
P
I
R
R
Site 30
T235
L
S
S
N
S
Q
R
T
P
I
R
R
D
F
S
Site 31
S242
T
P
I
R
R
D
F
S
A
S
Y
F
S
G
E
Site 32
S244
I
R
R
D
F
S
A
S
Y
F
S
G
E
Q
E
Site 33
Y245
R
R
D
F
S
A
S
Y
F
S
G
E
Q
E
V
Site 34
T253
F
S
G
E
Q
E
V
T
P
S
R
S
T
L
Q
Site 35
S255
G
E
Q
E
V
T
P
S
R
S
T
L
Q
I
G
Site 36
S257
Q
E
V
T
P
S
R
S
T
L
Q
I
G
K
R
Site 37
T258
E
V
T
P
S
R
S
T
L
Q
I
G
K
R
D
Site 38
S268
I
G
K
R
D
A
N
S
S
F
F
D
N
S
S
Site 39
S269
G
K
R
D
A
N
S
S
F
F
D
N
S
S
S
Site 40
S274
N
S
S
F
F
D
N
S
S
S
P
H
L
L
D
Site 41
S275
S
S
F
F
D
N
S
S
S
P
H
L
L
D
Q
Site 42
S276
S
F
F
D
N
S
S
S
P
H
L
L
D
Q
L
Site 43
T346
C
R
D
E
L
V
R
T
T
A
Q
Y
D
Q
A
Site 44
T347
R
D
E
L
V
R
T
T
A
Q
Y
D
Q
A
S
Site 45
Y350
L
V
R
T
T
A
Q
Y
D
Q
A
S
T
K
Y
Site 46
T368
E
Q
K
L
K
K
L
T
E
D
L
S
C
Q
R
Site 47
S372
K
K
L
T
E
D
L
S
C
Q
R
Q
N
A
E
Site 48
S380
C
Q
R
Q
N
A
E
S
A
R
C
S
L
E
Q
Site 49
S384
N
A
E
S
A
R
C
S
L
E
Q
K
I
K
E
Site 50
S401
K
E
F
Q
E
E
L
S
R
Q
Q
R
S
F
Q
Site 51
S406
E
L
S
R
Q
Q
R
S
F
Q
T
L
D
Q
E
Site 52
T422
I
Q
M
K
A
R
L
T
Q
E
L
Q
Q
A
K
Site 53
S444
A
E
L
D
K
L
T
S
V
K
Q
Q
L
E
N
Site 54
S480
K
E
N
E
L
R
R
S
M
E
E
M
K
K
E
Site 55
S493
K
E
N
N
L
L
K
S
H
S
E
Q
K
A
R
Site 56
S495
N
N
L
L
K
S
H
S
E
Q
K
A
R
E
V
Site 57
S532
E
M
K
A
K
N
T
S
Q
E
T
M
L
R
D
Site 58
T552
N
Q
Q
E
N
S
L
T
L
E
K
L
K
L
A
Site 59
S570
L
E
K
Q
R
D
C
S
Q
D
L
L
K
K
R
Site 60
S589
E
Q
L
N
D
K
L
S
K
T
E
K
E
S
K
Site 61
T591
L
N
D
K
L
S
K
T
E
K
E
S
K
A
L
Site 62
Y609
L
E
L
K
K
K
E
Y
E
E
L
K
E
E
K
Site 63
T617
E
E
L
K
E
E
K
T
L
F
S
C
W
K
S
Site 64
S620
K
E
E
K
T
L
F
S
C
W
K
S
E
N
E
Site 65
S624
T
L
F
S
C
W
K
S
E
N
E
K
L
L
T
Site 66
T631
S
E
N
E
K
L
L
T
Q
M
E
S
E
K
E
Site 67
S635
K
L
L
T
Q
M
E
S
E
K
E
N
L
Q
S
Site 68
T653
H
L
E
T
C
L
K
T
Q
Q
I
K
S
H
E
Site 69
S658
L
K
T
Q
Q
I
K
S
H
E
Y
N
E
R
V
Site 70
T667
E
Y
N
E
R
V
R
T
L
E
M
D
R
E
N
Site 71
S676
E
M
D
R
E
N
L
S
V
E
I
R
N
L
H
Site 72
S688
N
L
H
N
V
L
D
S
K
S
V
E
V
E
T
Site 73
S690
H
N
V
L
D
S
K
S
V
E
V
E
T
Q
K
Site 74
Y700
V
E
T
Q
K
L
A
Y
M
E
L
Q
Q
K
A
Site 75
S743
E
H
K
L
Q
L
L
S
N
E
I
M
D
K
D
Site 76
Y753
I
M
D
K
D
R
C
Y
Q
D
L
H
A
E
Y
Site 77
S762
D
L
H
A
E
Y
E
S
L
R
D
L
L
K
S
Site 78
S769
S
L
R
D
L
L
K
S
K
D
A
S
L
V
T
Site 79
S773
L
L
K
S
K
D
A
S
L
V
T
N
E
D
H
Site 80
S783
T
N
E
D
H
Q
R
S
L
L
A
F
D
Q
Q
Site 81
S806
N
I
I
G
E
Q
G
S
M
P
S
E
R
S
E
Site 82
S809
G
E
Q
G
S
M
P
S
E
R
S
E
C
R
L
Site 83
S812
G
S
M
P
S
E
R
S
E
C
R
L
E
A
D
Site 84
S821
C
R
L
E
A
D
Q
S
P
K
N
S
A
I
L
Site 85
S825
A
D
Q
S
P
K
N
S
A
I
L
Q
N
R
V
Site 86
S834
I
L
Q
N
R
V
D
S
L
E
F
S
L
E
S
Site 87
S838
R
V
D
S
L
E
F
S
L
E
S
Q
K
Q
M
Site 88
S841
S
L
E
F
S
L
E
S
Q
K
Q
M
N
S
D
Site 89
S847
E
S
Q
K
Q
M
N
S
D
L
Q
K
Q
C
E
Site 90
S876
K
A
E
Q
M
H
Q
S
F
V
A
E
T
S
Q
Site 91
S882
Q
S
F
V
A
E
T
S
Q
R
I
S
K
L
Q
Site 92
S886
A
E
T
S
Q
R
I
S
K
L
Q
E
D
T
S
Site 93
S893
S
K
L
Q
E
D
T
S
A
H
Q
N
V
V
A
Site 94
S933
E
I
Q
E
L
K
K
S
N
H
L
L
E
D
S
Site 95
S940
S
N
H
L
L
E
D
S
L
K
E
L
Q
L
L
Site 96
S948
L
K
E
L
Q
L
L
S
E
T
L
S
L
E
K
Site 97
S952
Q
L
L
S
E
T
L
S
L
E
K
K
E
M
S
Site 98
S959
S
L
E
K
K
E
M
S
S
I
I
S
L
N
K
Site 99
S963
K
E
M
S
S
I
I
S
L
N
K
R
E
I
E
Site 100
T973
K
R
E
I
E
E
L
T
Q
E
N
G
T
L
K
Site 101
S985
T
L
K
E
I
N
A
S
L
N
Q
E
K
M
N
Site 102
S999
N
L
I
Q
K
S
E
S
F
A
N
Y
I
D
E
Site 103
Y1003
K
S
E
S
F
A
N
Y
I
D
E
R
E
K
S
Site 104
S1010
Y
I
D
E
R
E
K
S
I
S
E
L
S
D
Q
Site 105
S1012
D
E
R
E
K
S
I
S
E
L
S
D
Q
Y
K
Site 106
S1015
E
K
S
I
S
E
L
S
D
Q
Y
K
Q
E
K
Site 107
Y1018
I
S
E
L
S
D
Q
Y
K
Q
E
K
L
I
L
Site 108
Y1036
C
E
E
T
G
N
A
Y
E
D
L
S
Q
K
Y
Site 109
S1040
G
N
A
Y
E
D
L
S
Q
K
Y
K
A
A
Q
Site 110
S1121
M
T
D
N
Q
N
N
S
K
S
E
A
G
G
L
Site 111
S1123
D
N
Q
N
N
S
K
S
E
A
G
G
L
K
Q
Site 112
S1177
E
S
E
P
I
R
N
S
V
K
E
R
E
S
E
Site 113
S1183
N
S
V
K
E
R
E
S
E
R
N
Q
C
N
F
Site 114
S1202
D
L
E
V
K
E
I
S
L
D
S
Y
N
A
Q
Site 115
S1205
V
K
E
I
S
L
D
S
Y
N
A
Q
L
V
Q
Site 116
Y1206
K
E
I
S
L
D
S
Y
N
A
Q
L
V
Q
L
Site 117
S1227
K
E
L
K
L
Q
E
S
E
K
E
K
E
C
L
Site 118
T1247
T
I
R
G
D
L
E
T
S
N
L
Q
D
M
Q
Site 119
S1248
I
R
G
D
L
E
T
S
N
L
Q
D
M
Q
S
Site 120
S1255
S
N
L
Q
D
M
Q
S
Q
E
I
S
G
L
K
Site 121
S1259
D
M
Q
S
Q
E
I
S
G
L
K
D
C
E
I
Site 122
Y1272
E
I
D
A
E
E
K
Y
I
S
G
P
H
E
L
Site 123
S1274
D
A
E
E
K
Y
I
S
G
P
H
E
L
S
T
Site 124
S1280
I
S
G
P
H
E
L
S
T
S
Q
N
D
N
A
Site 125
S1282
G
P
H
E
L
S
T
S
Q
N
D
N
A
H
L
Site 126
T1296
L
Q
C
S
L
Q
T
T
M
N
K
L
N
E
L
Site 127
Y1315
E
I
L
Q
A
E
K
Y
E
L
V
T
E
L
N
Site 128
S1324
L
V
T
E
L
N
D
S
R
S
E
C
I
T
A
Site 129
S1326
T
E
L
N
D
S
R
S
E
C
I
T
A
T
R
Site 130
T1330
D
S
R
S
E
C
I
T
A
T
R
K
M
A
E
Site 131
S1353
V
K
I
L
N
D
D
S
G
L
L
H
G
E
L
Site 132
S1380
P
N
E
Q
H
P
V
S
L
A
P
L
D
E
S
Site 133
S1387
S
L
A
P
L
D
E
S
N
S
Y
E
H
L
T
Site 134
S1389
A
P
L
D
E
S
N
S
Y
E
H
L
T
L
S
Site 135
Y1390
P
L
D
E
S
N
S
Y
E
H
L
T
L
S
D
Site 136
T1394
S
N
S
Y
E
H
L
T
L
S
D
K
E
V
Q
Site 137
S1396
S
Y
E
H
L
T
L
S
D
K
E
V
Q
M
H
Site 138
S1413
E
L
Q
E
K
F
L
S
L
Q
S
E
H
K
I
Site 139
S1416
E
K
F
L
S
L
Q
S
E
H
K
I
L
H
D
Site 140
S1433
C
Q
M
S
S
K
M
S
E
L
Q
T
Y
V
D
Site 141
T1437
S
K
M
S
E
L
Q
T
Y
V
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L
D
K
Y
C
S
L
L
I
S
H
Site 294
S2962
E
Y
L
D
K
Y
C
S
L
L
I
S
H
E
K
Site 295
S2966
K
Y
C
S
L
L
I
S
H
E
K
L
E
K
A
Site 296
T2979
K
A
K
E
M
L
E
T
Q
V
A
H
L
C
S
Site 297
S2986
T
Q
V
A
H
L
C
S
Q
Q
S
K
Q
D
S
Site 298
S2989
A
H
L
C
S
Q
Q
S
K
Q
D
S
R
G
S
Site 299
S2993
S
Q
Q
S
K
Q
D
S
R
G
S
P
L
L
G
Site 300
S2996
S
K
Q
D
S
R
G
S
P
L
L
G
P
V
V
Site 301
S3007
G
P
V
V
P
G
P
S
P
I
P
S
V
T
E
Site 302
S3011
P
G
P
S
P
I
P
S
V
T
E
K
R
L
S
Site 303
T3013
P
S
P
I
P
S
V
T
E
K
R
L
S
S
G
Site 304
S3018
S
V
T
E
K
R
L
S
S
G
Q
N
K
A
S
Site 305
S3019
V
T
E
K
R
L
S
S
G
Q
N
K
A
S
G
Site 306
S3025
S
S
G
Q
N
K
A
S
G
K
R
Q
R
S
S
Site 307
S3031
A
S
G
K
R
Q
R
S
S
G
I
W
E
N
G
Site 308
S3032
S
G
K
R
Q
R
S
S
G
I
W
E
N
G
R
Site 309
T3042
W
E
N
G
R
G
P
T
P
A
T
P
E
S
F
Site 310
T3045
G
R
G
P
T
P
A
T
P
E
S
F
S
K
K
Site 311
S3048
P
T
P
A
T
P
E
S
F
S
K
K
S
K
K
Site 312
S3050
P
A
T
P
E
S
F
S
K
K
S
K
K
A
V
Site 313
S3053
P
E
S
F
S
K
K
S
K
K
A
V
M
S
G
Site 314
T3090
K
G
F
A
D
I
P
T
G
K
T
S
P
Y
I
Site 315
T3093
A
D
I
P
T
G
K
T
S
P
Y
I
L
R
R
Site 316
S3094
D
I
P
T
G
K
T
S
P
Y
I
L
R
R
T
Site 317
Y3096
P
T
G
K
T
S
P
Y
I
L
R
R
T
T
M
Site 318
T3101
S
P
Y
I
L
R
R
T
T
M
A
T
R
T
S
Site 319
T3102
P
Y
I
L
R
R
T
T
M
A
T
R
T
S
P
Site 320
T3105
L
R
R
T
T
M
A
T
R
T
S
P
R
L
A
Site 321
S3108
T
T
M
A
T
R
T
S
P
R
L
A
A
Q
K
Site 322
S3119
A
A
Q
K
L
A
L
S
P
L
S
L
G
K
E
Site 323
S3122
K
L
A
L
S
P
L
S
L
G
K
E
N
L
A
Site 324
S3131
G
K
E
N
L
A
E
S
S
K
P
T
A
G
G
Site 325
S3132
K
E
N
L
A
E
S
S
K
P
T
A
G
G
S
Site 326
T3135
L
A
E
S
S
K
P
T
A
G
G
S
R
S
Q
Site 327
S3139
S
K
P
T
A
G
G
S
R
S
Q
K
V
K
V
Site 328
S3141
P
T
A
G
G
S
R
S
Q
K
V
K
V
A
Q
Site 329
S3150
K
V
K
V
A
Q
R
S
P
V
D
S
G
T
I
Site 330
S3154
A
Q
R
S
P
V
D
S
G
T
I
L
R
E
P
Site 331
T3156
R
S
P
V
D
S
G
T
I
L
R
E
P
T
T
Site 332
T3162
G
T
I
L
R
E
P
T
T
K
S
V
P
V
N
Site 333
T3163
T
I
L
R
E
P
T
T
K
S
V
P
V
N
N
Site 334
S3165
L
R
E
P
T
T
K
S
V
P
V
N
N
L
P
Site 335
S3175
V
N
N
L
P
E
R
S
P
T
D
S
P
R
E
Site 336
T3177
N
L
P
E
R
S
P
T
D
S
P
R
E
G
L
Site 337
S3179
P
E
R
S
P
T
D
S
P
R
E
G
L
R
V
Site 338
S3194
K
R
G
R
L
V
P
S
P
K
A
G
L
E
S
Site 339
S3201
S
P
K
A
G
L
E
S
N
G
S
E
N
C
K
Site 340
S3204
A
G
L
E
S
N
G
S
E
N
C
K
V
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation