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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FNTB
Full Name:
Protein farnesyltransferase subunit beta
Alias:
CAAX farnesyltransferase beta subunit; CAAX farnesyltransferase subunit beta; Farnesyltransferase beta; Farnesyltransferase, CAAX box, beta; FPTB; PFTB; Protein farnesyltransferase beta subunit; RAS proteins prenyltransferase beta
Type:
EC 2.5.1.58; Transferase
Mass (Da):
48774
Number AA:
437
UniProt ID:
P49356
International Prot ID:
IPI00026817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004660
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0018347
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
P
S
S
F
T
Y
Y
Site 2
S5
_
_
_
M
A
S
P
S
S
F
T
Y
Y
C
P
Site 3
S6
_
_
M
A
S
P
S
S
F
T
Y
Y
C
P
P
Site 4
T8
M
A
S
P
S
S
F
T
Y
Y
C
P
P
S
S
Site 5
Y9
A
S
P
S
S
F
T
Y
Y
C
P
P
S
S
S
Site 6
Y10
S
P
S
S
F
T
Y
Y
C
P
P
S
S
S
P
Site 7
S14
F
T
Y
Y
C
P
P
S
S
S
P
V
W
S
E
Site 8
S15
T
Y
Y
C
P
P
S
S
S
P
V
W
S
E
P
Site 9
S16
Y
Y
C
P
P
S
S
S
P
V
W
S
E
P
L
Site 10
S20
P
S
S
S
P
V
W
S
E
P
L
Y
S
L
R
Site 11
Y24
P
V
W
S
E
P
L
Y
S
L
R
P
E
H
A
Site 12
S25
V
W
S
E
P
L
Y
S
L
R
P
E
H
A
R
Site 13
S39
R
E
R
L
Q
D
D
S
V
E
T
V
T
S
I
Site 14
S60
E
K
I
Q
E
V
F
S
S
Y
K
F
N
H
L
Site 15
Y81
Q
R
E
K
H
F
H
Y
L
K
R
G
L
R
Q
Site 16
T90
K
R
G
L
R
Q
L
T
D
A
Y
E
C
L
D
Site 17
Y93
L
R
Q
L
T
D
A
Y
E
C
L
D
A
S
R
Site 18
S135
Q
F
L
E
L
C
Q
S
P
E
G
G
F
G
G
Site 19
Y147
F
G
G
G
P
G
Q
Y
P
H
L
A
P
T
Y
Site 20
Y180
N
R
E
K
L
L
Q
Y
L
Y
S
L
K
Q
P
Site 21
Y182
E
K
L
L
Q
Y
L
Y
S
L
K
Q
P
D
G
Site 22
S183
K
L
L
Q
Y
L
Y
S
L
K
Q
P
D
G
S
Site 23
S190
S
L
K
Q
P
D
G
S
F
L
M
H
V
G
G
Site 24
S272
E
R
S
L
N
L
K
S
L
L
Q
W
V
T
S
Site 25
T278
K
S
L
L
Q
W
V
T
S
R
Q
M
R
F
E
Site 26
S279
S
L
L
Q
W
V
T
S
R
Q
M
R
F
E
G
Site 27
Y300
N
K
L
V
D
G
C
Y
S
F
W
Q
A
G
L
Site 28
S357
L
L
D
K
P
G
K
S
R
D
F
Y
H
T
C
Site 29
Y361
P
G
K
S
R
D
F
Y
H
T
C
Y
C
L
S
Site 30
Y401
L
Q
P
T
H
P
V
Y
N
I
G
P
D
K
V
Site 31
S431
E
E
L
K
D
E
T
S
A
E
P
A
T
D
_
Site 32
T436
E
T
S
A
E
P
A
T
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation