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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FNTA
Full Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Alias:
EC 2.5.1.58; EC 2.5.1.59; Farnesyltransferase, CAAX box, alpha; FPTA; PFTA; PGGT1A
Type:
Enzyme - Farnesyltransferase
Mass (Da):
44409
Number AA:
379
UniProt ID:
P49354
International Prot ID:
IPI00026813
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005875
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0004662
GO:0043014
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0090045
GO:0090044
GO:0018347
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
E
A
G
E
A
V
A
S
P
M
D
D
G
F
V
Site 2
S57
P
M
D
D
G
F
V
S
L
D
S
P
S
Y
V
Site 3
S60
D
G
F
V
S
L
D
S
P
S
Y
V
L
Y
R
Site 4
S62
F
V
S
L
D
S
P
S
Y
V
L
Y
R
D
R
Site 5
Y63
V
S
L
D
S
P
S
Y
V
L
Y
R
D
R
A
Site 6
Y66
D
S
P
S
Y
V
L
Y
R
D
R
A
E
W
A
Site 7
Y100
S
D
K
F
R
D
V
Y
D
Y
F
R
A
V
L
Site 8
Y102
K
F
R
D
V
Y
D
Y
F
R
A
V
L
Q
R
Site 9
S113
V
L
Q
R
D
E
R
S
E
R
A
F
K
L
T
Site 10
T120
S
E
R
A
F
K
L
T
R
D
A
I
E
L
N
Site 11
Y131
I
E
L
N
A
A
N
Y
T
V
W
H
F
R
R
Site 12
S143
F
R
R
V
L
L
K
S
L
Q
K
D
L
H
E
Site 13
Y154
D
L
H
E
E
M
N
Y
I
T
A
I
I
E
E
Site 14
S183
V
E
W
L
R
D
P
S
Q
E
L
E
F
I
A
Site 15
Y222
L
W
D
N
E
L
Q
Y
V
D
Q
L
L
K
E
Site 16
Y241
N
S
V
W
N
Q
R
Y
F
V
I
S
N
T
T
Site 17
Y279
H
N
E
S
A
W
N
Y
L
K
G
I
L
Q
D
Site 18
S290
I
L
Q
D
R
G
L
S
K
Y
P
N
L
L
N
Site 19
Y292
Q
D
R
G
L
S
K
Y
P
N
L
L
N
Q
L
Site 20
S305
Q
L
L
D
L
Q
P
S
H
S
S
P
Y
L
I
Site 21
T350
I
L
A
K
E
K
D
T
I
R
K
E
Y
W
R
Site 22
Y355
K
D
T
I
R
K
E
Y
W
R
Y
I
G
R
S
Site 23
Y358
I
R
K
E
Y
W
R
Y
I
G
R
S
L
Q
S
Site 24
S362
Y
W
R
Y
I
G
R
S
L
Q
S
K
H
S
T
Site 25
S368
R
S
L
Q
S
K
H
S
T
E
N
D
S
P
T
Site 26
T369
S
L
Q
S
K
H
S
T
E
N
D
S
P
T
N
Site 27
S373
K
H
S
T
E
N
D
S
P
T
N
V
Q
Q
_
Site 28
T375
S
T
E
N
D
S
P
T
N
V
Q
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation