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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLD2
Full Name:
DNA polymerase delta subunit 2
Alias:
DNA polymerase delta subunit p50; DNA polymerase subunit delta p50
Type:
Mass (Da):
51271
Number AA:
469
UniProt ID:
P49005
International Prot ID:
IPI00025616
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
Q
A
A
Q
R
A
H
T
L
L
S
P
P
S
A
Site 2
S15
Q
R
A
H
T
L
L
S
P
P
S
A
N
N
A
Site 3
S18
H
T
L
L
S
P
P
S
A
N
N
A
T
F
A
Site 4
T23
P
P
S
A
N
N
A
T
F
A
R
V
P
V
A
Site 5
T31
F
A
R
V
P
V
A
T
Y
T
N
S
S
Q
P
Site 6
Y32
A
R
V
P
V
A
T
Y
T
N
S
S
Q
P
F
Site 7
T33
R
V
P
V
A
T
Y
T
N
S
S
Q
P
F
R
Site 8
S35
P
V
A
T
Y
T
N
S
S
Q
P
F
R
L
G
Site 9
S36
V
A
T
Y
T
N
S
S
Q
P
F
R
L
G
E
Site 10
S45
P
F
R
L
G
E
R
S
F
S
R
Q
Y
A
H
Site 11
S47
R
L
G
E
R
S
F
S
R
Q
Y
A
H
I
Y
Site 12
Y50
E
R
S
F
S
R
Q
Y
A
H
I
Y
A
T
R
Site 13
Y54
S
R
Q
Y
A
H
I
Y
A
T
R
L
I
Q
M
Site 14
S106
K
A
M
P
L
Q
P
S
I
L
R
E
V
S
E
Site 15
S112
P
S
I
L
R
E
V
S
E
E
H
N
L
L
P
Site 16
S124
L
L
P
Q
P
P
R
S
K
Y
I
H
P
D
D
Site 17
Y126
P
Q
P
P
R
S
K
Y
I
H
P
D
D
E
L
Site 18
T147
Q
R
I
K
L
K
G
T
I
D
V
S
K
L
V
Site 19
S151
L
K
G
T
I
D
V
S
K
L
V
T
G
T
V
Site 20
T157
V
S
K
L
V
T
G
T
V
L
A
V
F
G
S
Site 21
S234
G
D
E
G
E
Q
C
S
A
A
H
V
S
R
V
Site 22
S249
I
L
A
G
N
L
L
S
H
S
T
Q
S
R
D
Site 23
S251
A
G
N
L
L
S
H
S
T
Q
S
R
D
S
I
Site 24
T252
G
N
L
L
S
H
S
T
Q
S
R
D
S
I
N
Site 25
S257
H
S
T
Q
S
R
D
S
I
N
K
A
K
Y
L
Site 26
Y263
D
S
I
N
K
A
K
Y
L
T
K
K
T
Q
A
Site 27
T268
A
K
Y
L
T
K
K
T
Q
A
A
S
V
E
A
Site 28
S272
T
K
K
T
Q
A
A
S
V
E
A
V
K
M
L
Site 29
T302
M
P
G
E
F
D
P
T
N
Y
T
L
P
Q
Q
Site 30
Y304
G
E
F
D
P
T
N
Y
T
L
P
Q
Q
P
L
Site 31
T305
E
F
D
P
T
N
Y
T
L
P
Q
Q
P
L
H
Site 32
S345
G
V
R
F
L
G
T
S
G
Q
N
V
S
D
I
Site 33
S350
G
T
S
G
Q
N
V
S
D
I
F
R
Y
S
S
Site 34
Y355
N
V
S
D
I
F
R
Y
S
S
M
E
D
H
L
Site 35
S356
V
S
D
I
F
R
Y
S
S
M
E
D
H
L
E
Site 36
S357
S
D
I
F
R
Y
S
S
M
E
D
H
L
E
I
Site 37
T368
H
L
E
I
L
E
W
T
L
R
V
R
H
I
S
Site 38
S375
T
L
R
V
R
H
I
S
P
T
A
P
D
T
L
Site 39
T377
R
V
R
H
I
S
P
T
A
P
D
T
L
G
C
Site 40
Y385
A
P
D
T
L
G
C
Y
P
F
Y
K
T
D
P
Site 41
Y402
F
P
E
C
P
H
V
Y
F
C
G
N
T
P
S
Site 42
T407
H
V
Y
F
C
G
N
T
P
S
F
G
S
K
I
Site 43
S409
Y
F
C
G
N
T
P
S
F
G
S
K
I
I
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation