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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A3
Full Name:
Anion exchange protein 3
Alias:
Anion exchange protein 3; B3A3; CAE3/BAE3; Neuronal band 3-like protein
Type:
Membrane fraction, Membrane, Integral plasma membrane protein; Transporter protein
Mass (Da):
135707
Number AA:
1232
UniProt ID:
P48751
International Prot ID:
IPI00011159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005452
PhosphoSite+
KinaseNET
Biological Process:
GO:0006820
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
I
P
P
P
G
G
A
S
P
L
P
Q
V
R
V
Site 2
S28
P
L
E
E
P
P
L
S
P
D
V
E
E
E
D
Site 3
T41
E
D
D
D
L
G
K
T
L
A
V
S
R
F
G
Site 4
S52
S
R
F
G
D
L
I
S
K
P
P
A
W
D
P
Site 5
S63
A
W
D
P
E
K
P
S
R
S
Y
S
E
R
D
Site 6
S65
D
P
E
K
P
S
R
S
Y
S
E
R
D
F
E
Site 7
Y66
P
E
K
P
S
R
S
Y
S
E
R
D
F
E
F
Site 8
S67
E
K
P
S
R
S
Y
S
E
R
D
F
E
F
H
Site 9
T81
H
R
H
T
S
H
H
T
H
H
P
L
S
A
R
Site 10
S86
H
H
T
H
H
P
L
S
A
R
L
P
P
P
H
Site 11
T101
K
L
R
R
L
P
P
T
S
A
R
H
T
R
R
Site 12
S102
L
R
R
L
P
P
T
S
A
R
H
T
R
R
K
Site 13
T106
P
P
T
S
A
R
H
T
R
R
K
R
K
K
E
Site 14
T115
R
K
R
K
K
E
K
T
S
A
P
P
S
E
G
Site 15
S116
K
R
K
K
E
K
T
S
A
P
P
S
E
G
T
Site 16
S120
E
K
T
S
A
P
P
S
E
G
T
P
P
I
Q
Site 17
T123
S
A
P
P
S
E
G
T
P
P
I
Q
E
E
G
Site 18
S148
E
E
E
E
E
G
E
S
E
A
E
P
V
E
P
Site 19
S158
E
P
V
E
P
P
P
S
G
T
P
Q
K
A
K
Site 20
T160
V
E
P
P
P
S
G
T
P
Q
K
A
K
F
S
Site 21
S167
T
P
Q
K
A
K
F
S
I
G
S
D
E
D
D
Site 22
S170
K
A
K
F
S
I
G
S
D
E
D
D
S
P
G
Site 23
S175
I
G
S
D
E
D
D
S
P
G
L
P
G
R
A
Site 24
S190
A
V
T
K
P
L
P
S
V
G
P
H
T
D
K
Site 25
T195
L
P
S
V
G
P
H
T
D
K
S
P
Q
H
S
Site 26
S198
V
G
P
H
T
D
K
S
P
Q
H
S
S
S
S
Site 27
S202
T
D
K
S
P
Q
H
S
S
S
S
P
S
P
R
Site 28
S203
D
K
S
P
Q
H
S
S
S
S
P
S
P
R
A
Site 29
S204
K
S
P
Q
H
S
S
S
S
P
S
P
R
A
R
Site 30
S205
S
P
Q
H
S
S
S
S
P
S
P
R
A
R
A
Site 31
S207
Q
H
S
S
S
S
P
S
P
R
A
R
A
S
R
Site 32
S213
P
S
P
R
A
R
A
S
R
L
A
G
E
K
S
Site 33
S220
S
R
L
A
G
E
K
S
R
P
W
S
P
S
A
Site 34
S224
G
E
K
S
R
P
W
S
P
S
A
S
Y
D
L
Site 35
S226
K
S
R
P
W
S
P
S
A
S
Y
D
L
R
E
Site 36
S228
R
P
W
S
P
S
A
S
Y
D
L
R
E
R
L
Site 37
S239
R
E
R
L
C
P
G
S
A
L
G
N
P
G
G
Site 38
S271
A
D
L
D
D
M
K
S
H
R
L
E
D
N
P
Site 39
S289
R
H
L
V
K
K
P
S
R
T
Q
G
G
R
G
Site 40
T291
L
V
K
K
P
S
R
T
Q
G
G
R
G
S
P
Site 41
S297
R
T
Q
G
G
R
G
S
P
S
G
L
A
P
I
Site 42
S299
Q
G
G
R
G
S
P
S
G
L
A
P
I
L
R
Site 43
S333
N
E
L
M
L
D
R
S
Q
E
P
H
W
R
E
Site 44
S406
V
V
E
T
M
I
V
S
D
Q
I
R
P
E
D
Site 45
T420
D
R
A
S
V
L
R
T
L
L
L
K
H
S
H
Site 46
S426
R
T
L
L
L
K
H
S
H
P
N
D
D
K
D
Site 47
S434
H
P
N
D
D
K
D
S
G
F
F
P
R
N
P
Site 48
S442
G
F
F
P
R
N
P
S
S
S
S
M
N
S
V
Site 49
S443
F
F
P
R
N
P
S
S
S
S
M
N
S
V
L
Site 50
S444
F
P
R
N
P
S
S
S
S
M
N
S
V
L
G
Site 51
S445
P
R
N
P
S
S
S
S
M
N
S
V
L
G
N
Site 52
S448
P
S
S
S
S
M
N
S
V
L
G
N
H
H
P
Site 53
T456
V
L
G
N
H
H
P
T
P
S
H
G
P
D
G
Site 54
S458
G
N
H
H
P
T
P
S
H
G
P
D
G
A
V
Site 55
S502
G
D
G
H
R
G
K
S
L
K
L
L
E
K
I
Site 56
S562
L
F
V
M
L
G
P
S
H
T
S
T
D
Y
H
Site 57
T566
L
G
P
S
H
T
S
T
D
Y
H
E
L
G
R
Site 58
Y568
P
S
H
T
S
T
D
Y
H
E
L
G
R
S
I
Site 59
S574
D
Y
H
E
L
G
R
S
I
A
T
L
M
S
D
Site 60
S580
R
S
I
A
T
L
M
S
D
K
L
F
H
E
A
Site 61
S599
D
D
R
Q
D
L
L
S
A
I
S
E
F
L
D
Site 62
S614
G
S
I
V
I
P
P
S
E
V
E
G
R
D
L
Site 63
S624
E
G
R
D
L
L
R
S
V
A
A
F
Q
R
E
Site 64
T642
K
R
R
E
R
E
Q
T
K
V
E
M
T
T
R
Site 65
Y652
E
M
T
T
R
G
G
Y
T
A
P
G
K
E
L
Site 66
S660
T
A
P
G
K
E
L
S
L
E
L
G
G
S
E
Site 67
S666
L
S
L
E
L
G
G
S
E
A
T
P
E
D
D
Site 68
T669
E
L
G
G
S
E
A
T
P
E
D
D
P
L
L
Site 69
T678
E
D
D
P
L
L
R
T
G
S
V
F
G
G
L
Site 70
S680
D
P
L
L
R
T
G
S
V
F
G
G
L
V
R
Site 71
Y693
V
R
D
V
R
R
R
Y
P
H
Y
P
S
D
L
Site 72
Y696
V
R
R
R
Y
P
H
Y
P
S
D
L
R
D
A
Site 73
Y789
C
R
A
Q
D
L
E
Y
L
T
G
R
V
W
V
Site 74
Y818
E
G
S
F
L
V
R
Y
I
S
P
F
T
Q
E
Site 75
Y844
Y
E
T
F
Y
K
L
Y
K
V
F
T
E
H
P
Site 76
T848
Y
K
L
Y
K
V
F
T
E
H
P
L
L
P
F
Site 77
Y856
E
H
P
L
L
P
F
Y
P
P
E
G
A
L
E
Site 78
S865
P
E
G
A
L
E
G
S
L
A
A
G
L
E
P
Site 79
S875
A
G
L
E
P
N
G
S
A
L
P
P
T
E
G
Site 80
T880
N
G
S
A
L
P
P
T
E
G
P
P
S
P
R
Site 81
S885
P
P
T
E
G
P
P
S
P
R
N
Q
P
N
T
Site 82
T892
S
P
R
N
Q
P
N
T
A
L
L
S
L
I
L
Site 83
S916
F
L
R
K
F
R
N
S
R
F
L
G
G
K
A
Site 84
T949
V
D
Y
S
I
T
D
T
Y
T
Q
K
L
T
V
Site 85
Y950
D
Y
S
I
T
D
T
Y
T
Q
K
L
T
V
P
Site 86
T955
D
T
Y
T
Q
K
L
T
V
P
T
G
L
S
V
Site 87
S961
L
T
V
P
T
G
L
S
V
T
S
P
D
K
R
Site 88
S964
P
T
G
L
S
V
T
S
P
D
K
R
S
W
F
Site 89
S969
V
T
S
P
D
K
R
S
W
F
I
P
P
L
G
Site 90
T1061
V
T
H
V
N
A
L
T
V
M
R
T
A
I
A
Site 91
S1123
Y
M
G
V
T
S
L
S
G
I
Q
L
S
Q
R
Site 92
Y1146
K
H
H
P
E
Q
P
Y
V
T
K
V
K
T
W
Site 93
S1174
A
L
L
W
V
V
K
S
T
A
A
S
L
A
F
Site 94
T1175
L
L
W
V
V
K
S
T
A
A
S
L
A
F
P
Site 95
S1178
V
V
K
S
T
A
A
S
L
A
F
P
F
L
L
Site 96
S1210
R
E
L
Q
A
L
D
S
E
D
A
E
P
N
F
Site 97
Y1225
D
E
D
G
Q
D
E
Y
N
E
L
H
M
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation