PhosphoNET

           
Protein Info 
   
Short Name:  Cytokeratin 6E
Full Name:  Keratin, type II cytoskeletal 6C
Alias:  CK 6E; Cytokeratin-6C; Cytokeratin-6E; CK 6C; K6; KRT6C
Type:  Cytoskeletal protein
Mass (Da):  60025
Number AA:  564
UniProt ID:  P48668
International Prot ID:  IPI00299145
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0045095     Uniprot OncoNet
Molecular Function:  GO:0005198     PhosphoSite+ KinaseNET
Biological Process:  GO:0007010     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T6__MASTSTTIRSHSS
Site 2T7_MASTSTTIRSHSSS
Site 3S10STSTTIRSHSSSRRG
Site 4S12STTIRSHSSSRRGFS
Site 5S13TTIRSHSSSRRGFSA
Site 6S14TIRSHSSSRRGFSAN
Site 7S19SSSRRGFSANSARLP
Site 8S22RRGFSANSARLPGVS
Site 9S29SARLPGVSRSGFSSI
Site 10S31RLPGVSRSGFSSISV
Site 11S34GVSRSGFSSISVSRS
Site 12S35VSRSGFSSISVSRSR
Site 13S37RSGFSSISVSRSRGS
Site 14S39GFSSISVSRSRGSGG
Site 15S41SSISVSRSRGSGGLG
Site 16S44SVSRSRGSGGLGGAC
Site 17S58CGGAGFGSRSLYGLG
Site 18S60GAGFGSRSLYGLGGS
Site 19Y62GFGSRSLYGLGGSKR
Site 20S67SLYGLGGSKRISIGG
Site 21S71LGGSKRISIGGGSCA
Site 22S76RISIGGGSCAISGGY
Site 23S80GGGSCAISGGYGSRA
Site 24Y83SCAISGGYGSRAGGS
Site 25S85AISGGYGSRAGGSYG
Site 26S90YGSRAGGSYGFGGAG
Site 27Y91GSRAGGSYGFGGAGS
Site 28T146TVNQSLLTPLNLQID
Site 29T169EEREQIKTLNNKFAS
Site 30S176TLNNKFASFIDKVRF
Site 31T205LQEQGTKTVRQNLEP
Site 32S227NLRRQLDSIVGERGR
Site 33S237GERGRLDSELRNMQD
Site 34Y253VEDLKNKYEDEINKR
Site 35Y278KKDVDAAYMNKVELQ
Site 36T290ELQAKADTLTDEINF
Site 37T292QAKADTLTDEINFLR
Site 38S307ALYDAELSQMQTHIS
Site 39T311AELSQMQTHISDTSV
Site 40S314SQMQTHISDTSVVLS
Site 41T316MQTHISDTSVVLSMD
Site 42S317QTHISDTSVVLSMDN
Site 43S321SDTSVVLSMDNNRNL
Site 44S332NRNLDLDSIIAEVKA
Site 45Y341IAEVKAQYEEIAQRS
Site 46S348YEEIAQRSRAEAESW
Site 47S354RSRAEAESWYQTKYE
Site 48Y356RAEAESWYQTKYEEL
Site 49T358EAESWYQTKYEELQV
Site 50Y360ESWYQTKYEELQVTA
Site 51T366KYEELQVTAGRHGDD
Site 52T377HGDDLRNTKQEIAEI
Site 53S393RMIQRLRSEIDHVKK
Site 54S404HVKKQCASLQAAIAD
Site 55Y448LARLLKEYQELMNVK
Site 56Y465LDVEIATYRKLLEGE
Site 57S494SVVQSTISSGYGGAS
Site 58S501SSGYGGASGVGSGLG
Site 59S513GLGLGGGSSYSYGSG
Site 60S514LGLGGGSSYSYGSGL
Site 61Y515GLGGGSSYSYGSGLG
Site 62Y517GGGSSYSYGSGLGIG
Site 63S519GSSYSYGSGLGIGGG
Site 64S529GIGGGFSSSSGRAIG
Site 65S530IGGGFSSSSGRAIGG
Site 66S531GGGFSSSSGRAIGGG
Site 67S540RAIGGGLSSVGGGSS
Site 68S541AIGGGLSSVGGGSST
Site 69S547SSVGGGSSTIKYTTT
Site 70T548SVGGGSSTIKYTTTS
Site 71Y551GGSSTIKYTTTSSSS
Site 72T552GSSTIKYTTTSSSSR
Site 73T553SSTIKYTTTSSSSRK
Site 74T554STIKYTTTSSSSRKS
Site 75S555TIKYTTTSSSSRKSY
Site 76S556IKYTTTSSSSRKSYK
Site 77S557KYTTTSSSSRKSYKH
Site 78S558KYTTTSSSSRKSYKH
Site 79S561TSSSSRKSYKH____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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