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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GCLC
Full Name:
Glutamate--cysteine ligase catalytic subunit
Alias:
Gamma-ECS; Gamma-glutamylcysteine synthetase; GCS; GCS heavy chain; GLCL; GLCLC; Glutamate-cysteine ligase catalytic; Glutamate-cysteine ligase, catalytic; Glutamate-cysteine ligase, catalytic subunit; GSH1
Type:
Other Amino Acids Metabolism - glutathione; EC 6.3.2.2; Ligase
Mass (Da):
72766
Number AA:
637
UniProt ID:
P48506
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0043531
GO:0005524
GO:0050662
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0045454
GO:0006534
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
G
L
L
S
Q
G
S
P
L
S
W
Site 2
S8
M
G
L
L
S
Q
G
S
P
L
S
W
E
E
T
Site 3
S11
L
S
Q
G
S
P
L
S
W
E
E
T
K
R
H
Site 4
T15
S
P
L
S
W
E
E
T
K
R
H
A
D
H
V
Site 5
Y34
I
L
Q
F
L
H
I
Y
H
A
V
K
D
R
H
Site 6
Y53
K
W
G
D
E
V
E
Y
M
L
V
S
F
D
H
Site 7
S57
E
V
E
Y
M
L
V
S
F
D
H
E
N
K
K
Site 8
S70
K
K
V
R
L
V
L
S
G
E
K
V
L
E
T
Site 9
T77
S
G
E
K
V
L
E
T
L
Q
E
K
G
E
R
Site 10
Y97
P
T
L
W
R
P
E
Y
G
S
Y
M
I
E
G
Site 11
Y100
W
R
P
E
Y
G
S
Y
M
I
E
G
T
P
G
Site 12
T105
G
S
Y
M
I
E
G
T
P
G
Q
P
Y
G
G
Site 13
Y110
E
G
T
P
G
Q
P
Y
G
G
T
M
S
E
F
Site 14
T113
P
G
Q
P
Y
G
G
T
M
S
E
F
N
T
V
Site 15
S115
Q
P
Y
G
G
T
M
S
E
F
N
T
V
E
A
Site 16
T119
G
T
M
S
E
F
N
T
V
E
A
N
M
R
K
Site 17
T132
R
K
R
R
K
E
A
T
S
I
L
E
E
N
Q
Site 18
S133
K
R
R
K
E
A
T
S
I
L
E
E
N
Q
A
Site 19
T143
E
E
N
Q
A
L
C
T
I
T
S
F
P
R
L
Site 20
S170
N
P
V
E
G
G
A
S
K
S
L
F
F
P
D
Site 21
S172
V
E
G
G
A
S
K
S
L
F
F
P
D
E
A
Site 22
S187
I
N
K
H
P
R
F
S
T
L
T
R
N
I
R
Site 23
T188
N
K
H
P
R
F
S
T
L
T
R
N
I
R
H
Site 24
T190
H
P
R
F
S
T
L
T
R
N
I
R
H
R
R
Site 25
T213
P
I
F
K
D
K
N
T
P
S
P
F
I
E
T
Site 26
S215
F
K
D
K
N
T
P
S
P
F
I
E
T
F
T
Site 27
S228
F
T
E
D
D
E
A
S
R
A
S
K
P
D
H
Site 28
S231
D
D
E
A
S
R
A
S
K
P
D
H
I
Y
M
Site 29
Y237
A
S
K
P
D
H
I
Y
M
D
A
M
G
F
G
Site 30
S260
T
F
Q
A
C
S
I
S
E
A
R
Y
L
Y
D
Site 31
Y264
C
S
I
S
E
A
R
Y
L
Y
D
Q
L
A
T
Site 32
Y289
A
S
P
F
Y
R
G
Y
V
S
D
I
D
C
R
Site 33
S301
D
C
R
W
G
V
I
S
A
S
V
D
D
R
T
Site 34
S303
R
W
G
V
I
S
A
S
V
D
D
R
T
R
E
Site 35
T308
S
A
S
V
D
D
R
T
R
E
E
R
G
L
E
Site 36
Y322
E
P
L
K
N
N
N
Y
R
I
S
K
S
R
Y
Site 37
S325
K
N
N
N
Y
R
I
S
K
S
R
Y
D
S
I
Site 38
S327
N
N
Y
R
I
S
K
S
R
Y
D
S
I
D
S
Site 39
Y329
Y
R
I
S
K
S
R
Y
D
S
I
D
S
Y
L
Site 40
S331
I
S
K
S
R
Y
D
S
I
D
S
Y
L
S
K
Site 41
S334
S
R
Y
D
S
I
D
S
Y
L
S
K
C
G
E
Site 42
Y335
R
Y
D
S
I
D
S
Y
L
S
K
C
G
E
K
Site 43
S337
D
S
I
D
S
Y
L
S
K
C
G
E
K
Y
N
Site 44
Y343
L
S
K
C
G
E
K
Y
N
D
I
D
L
T
I
Site 45
T349
K
Y
N
D
I
D
L
T
I
D
K
E
I
Y
E
Site 46
T381
L
F
I
R
D
P
L
T
L
F
E
E
K
I
H
Site 47
S418
F
K
P
P
P
P
N
S
D
I
G
W
R
V
E
Site 48
T434
R
P
M
E
V
Q
L
T
D
F
E
N
S
A
Y
Site 49
S464
L
D
F
L
I
P
L
S
K
V
D
E
N
M
K
Site 50
T522
Y
T
L
M
S
I
D
T
I
I
N
G
K
E
G
Site 51
Y558
T
R
C
S
I
L
N
Y
L
K
L
I
K
K
R
Site 52
S567
K
L
I
K
K
R
A
S
G
E
L
M
T
V
A
Site 53
T572
R
A
S
G
E
L
M
T
V
A
R
W
M
R
E
Site 54
Y587
F
I
A
N
H
P
D
Y
K
Q
D
S
V
I
T
Site 55
S621
E
C
P
E
L
L
G
S
A
F
R
K
V
K
Y
Site 56
Y628
S
A
F
R
K
V
K
Y
S
G
S
K
T
D
S
Site 57
S629
A
F
R
K
V
K
Y
S
G
S
K
T
D
S
S
Site 58
S631
R
K
V
K
Y
S
G
S
K
T
D
S
S
N
_
Site 59
T633
V
K
Y
S
G
S
K
T
D
S
S
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation