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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LSS
Full Name:
Lanosterol synthase
Alias:
2,3-epoxysqualene-lanosterol cyclase; 2,3-oxidosqualene-lanosterol cyclase; ERG7; OSC; Oxidosqualene-lanosterol cyclase; Oxidosqualene--lanosterol cyclase
Type:
Isomerase; EC 5.4.99.7; Lipid Metabolism - steroid biosynthesis
Mass (Da):
83309
Number AA:
732
UniProt ID:
P48449
International Prot ID:
IPI00009747
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000250
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
R
R
G
G
P
Y
K
T
E
P
A
T
D
L
G
Site 2
Y38
R
G
R
Q
T
W
T
Y
L
Q
D
E
R
A
G
Site 3
T49
E
R
A
G
R
E
Q
T
G
L
E
A
Y
A
L
Site 4
Y63
L
G
L
D
T
K
N
Y
F
K
D
L
P
K
A
Site 5
Y98
D
G
H
W
T
G
D
Y
G
G
P
L
F
L
L
Site 6
Y130
Y
R
E
E
I
V
R
Y
L
R
S
V
Q
L
P
Site 7
S133
E
I
V
R
Y
L
R
S
V
Q
L
P
D
G
G
Site 8
T150
L
H
I
E
D
K
S
T
V
F
G
T
A
L
N
Site 9
S258
A
E
D
P
L
V
Q
S
L
R
Q
E
L
Y
V
Site 10
Y264
Q
S
L
R
Q
E
L
Y
V
E
D
F
A
S
I
Site 11
S270
L
Y
V
E
D
F
A
S
I
D
W
L
A
Q
R
Site 12
Y286
N
V
A
P
D
E
L
Y
T
P
H
S
W
L
L
Site 13
T287
V
A
P
D
E
L
Y
T
P
H
S
W
L
L
R
Site 14
S290
D
E
L
Y
T
P
H
S
W
L
L
R
V
V
Y
Site 15
Y303
V
Y
A
L
L
N
L
Y
E
H
H
H
S
A
H
Site 16
Y320
Q
R
A
V
Q
K
L
Y
E
H
I
V
A
D
D
Site 17
S332
A
D
D
R
F
T
K
S
I
S
I
G
P
I
S
Site 18
S334
D
R
F
T
K
S
I
S
I
G
P
I
S
K
T
Site 19
Y368
H
V
S
R
I
P
D
Y
L
W
M
G
L
D
G
Site 20
S409
H
H
R
P
E
F
S
S
C
L
Q
K
A
H
E
Site 21
S421
A
H
E
F
L
R
L
S
Q
V
P
D
N
P
P
Site 22
Y430
V
P
D
N
P
P
D
Y
Q
K
Y
Y
R
Q
M
Site 23
Y433
N
P
P
D
Y
Q
K
Y
Y
R
Q
M
R
K
G
Site 24
Y434
P
P
D
Y
Q
K
Y
Y
R
Q
M
R
K
G
G
Site 25
S443
Q
M
R
K
G
G
F
S
F
S
T
L
D
C
G
Site 26
S445
R
K
G
G
F
S
F
S
T
L
D
C
G
W
I
Site 27
T475
Q
E
K
C
P
H
V
T
E
H
I
P
R
E
R
Site 28
Y503
P
D
G
G
F
A
T
Y
E
T
K
R
G
G
H
Site 29
T505
G
G
F
A
T
Y
E
T
K
R
G
G
H
L
L
Site 30
Y543
A
V
M
Q
A
L
K
Y
F
H
K
R
F
P
E
Site 31
T559
R
A
A
E
I
R
E
T
L
T
Q
G
L
E
F
Site 32
S576
R
Q
Q
R
A
D
G
S
W
E
G
S
W
G
V
Site 33
T607
G
Q
T
Y
R
D
G
T
A
C
A
E
V
S
R
Site 34
S621
R
A
C
D
F
L
L
S
R
Q
M
A
D
G
G
Site 35
S635
G
W
G
E
D
F
E
S
C
E
E
R
R
Y
L
Site 36
Y641
E
S
C
E
E
R
R
Y
L
Q
S
A
Q
S
Q
Site 37
S644
E
E
R
R
Y
L
Q
S
A
Q
S
Q
I
H
N
Site 38
S720
I
W
A
L
G
R
F
S
Q
L
Y
P
E
R
A
Site 39
Y723
L
G
R
F
S
Q
L
Y
P
E
R
A
L
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation