PhosphoNET

           
Protein Info 
   
Short Name:  SOX2
Full Name:  Transcription factor SOX-2
Alias:  SRY (sex determining region Y)-box 2
Type:  Transcription factor; DNA binding protein; Cell development/differentiation
Mass (Da):  34310
Number AA:  317
UniProt ID:  P48431
International Prot ID:  IPI00009703
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829     Uniprot OncoNet
Molecular Function:  GO:0035198  GO:0010843  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0007050  GO:0006325  GO:0021781 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S18PPGPQQTSGGGGGNS
Site 2S25SGGGGGNSTAAAAGG
Site 3T26GGGGGNSTAAAAGGN
Site 4S37AGGNQKNSPDRVKRP
Site 5S69ENPKMHNSEISKRLG
Site 6S72KMHNSEISKRLGAEW
Site 7S83GAEWKLLSETEKRPF
Site 8Y108HMKEHPDYKYRPRRK
Site 9Y110KEHPDYKYRPRRKTK
Site 10T116KYRPRRKTKTLMKKD
Site 11T118RPRRKTKTLMKKDKY
Site 12Y125TLMKKDKYTLPGGLL
Site 13T126LMKKDKYTLPGGLLA
Site 14S138LLAPGGNSMASGVGV
Site 15Y171NGWSNGSYSMMQDQL
Site 16Y180MMQDQLGYPQHPGLN
Site 17Y200QMQPMHRYDVSALQY
Site 18Y207YDVSALQYNSMTSSQ
Site 19S209VSALQYNSMTSSQTY
Site 20S213QYNSMTSSQTYMNGS
Site 21Y216SMTSSQTYMNGSPTY
Site 22S220SQTYMNGSPTYSMSY
Site 23T222TYMNGSPTYSMSYSQ
Site 24S224MNGSPTYSMSYSQQG
Site 25S226GSPTYSMSYSQQGTP
Site 26S228PTYSMSYSQQGTPGM
Site 27T232MSYSQQGTPGMALGS
Site 28S246SMGSVVKSEASSSPP
Site 29S249SVVKSEASSSPPVVT
Site 30S250VVKSEASSSPPVVTS
Site 31S251VKSEASSSPPVVTSS
Site 32T256SSSPPVVTSSSHSRA
Site 33S257SSPPVVTSSSHSRAP
Site 34S258SPPVVTSSSHSRAPC
Site 35S259PPVVTSSSHSRAPCQ
Site 36S261VVTSSSHSRAPCQAG
Site 37S275GDLRDMISMYLPGAE
Site 38S295APSRLHMSQHYQSGP
Site 39Y298RLHMSQHYQSGPVPG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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