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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX5
Full Name:
DNA-binding protein RFX5
Alias:
Regulatory factor X 5; Regulatory factor X subunit 5; Regulatory factor X, 5 (influences HLA class II expression)
Type:
Transcription factor
Mass (Da):
65323
Number AA:
616
UniProt ID:
P48382
International Prot ID:
IPI00009303
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
D
E
P
D
A
K
S
P
K
T
G
G
R
A
Site 2
T13
P
D
A
K
S
P
K
T
G
G
R
A
P
P
G
Site 3
T28
G
A
E
A
G
E
P
T
T
L
L
Q
R
L
R
Site 4
T37
L
L
Q
R
L
R
G
T
I
S
K
A
V
Q
N
Site 5
S39
Q
R
L
R
G
T
I
S
K
A
V
Q
N
K
V
Site 6
S57
L
Q
D
V
Q
K
F
S
D
N
D
K
L
Y
L
Site 7
Y63
F
S
D
N
D
K
L
Y
L
Y
L
Q
L
P
S
Site 8
Y65
D
N
D
K
L
Y
L
Y
L
Q
L
P
S
G
P
Site 9
T74
Q
L
P
S
G
P
T
T
G
D
K
S
S
E
P
Site 10
S78
G
P
T
T
G
D
K
S
S
E
P
S
T
L
S
Site 11
S79
P
T
T
G
D
K
S
S
E
P
S
T
L
S
N
Site 12
S82
G
D
K
S
S
E
P
S
T
L
S
N
E
E
Y
Site 13
T83
D
K
S
S
E
P
S
T
L
S
N
E
E
Y
M
Site 14
S85
S
S
E
P
S
T
L
S
N
E
E
Y
M
Y
A
Site 15
Y89
S
T
L
S
N
E
E
Y
M
Y
A
Y
R
W
I
Site 16
Y91
L
S
N
E
E
Y
M
Y
A
Y
R
W
I
R
N
Site 17
T106
H
L
E
E
H
T
D
T
C
L
P
K
Q
S
V
Site 18
S112
D
T
C
L
P
K
Q
S
V
Y
D
A
Y
R
K
Site 19
Y114
C
L
P
K
Q
S
V
Y
D
A
Y
R
K
Y
C
Site 20
Y117
K
Q
S
V
Y
D
A
Y
R
K
Y
C
E
S
L
Site 21
Y120
V
Y
D
A
Y
R
K
Y
C
E
S
L
A
C
C
Site 22
S157
R
L
G
G
R
G
Q
S
K
Y
C
Y
S
G
I
Site 23
Y159
G
G
R
G
Q
S
K
Y
C
Y
S
G
I
R
R
Site 24
Y161
R
G
Q
S
K
Y
C
Y
S
G
I
R
R
K
T
Site 25
S162
G
Q
S
K
Y
C
Y
S
G
I
R
R
K
T
L
Site 26
T168
Y
S
G
I
R
R
K
T
L
V
S
M
P
P
L
Site 27
S183
P
G
L
D
L
K
G
S
E
S
P
E
M
G
P
Site 28
S185
L
D
L
K
G
S
E
S
P
E
M
G
P
E
V
Site 29
T193
P
E
M
G
P
E
V
T
P
A
P
R
D
E
L
Site 30
S219
A
E
R
I
L
K
R
S
F
S
S
I
V
E
V
Site 31
S221
R
I
L
K
R
S
F
S
S
I
V
E
V
A
R
Site 32
S237
L
L
Q
Q
H
L
I
S
A
R
S
A
H
A
H
Site 33
S263
E
H
A
P
R
E
R
S
S
K
P
K
N
G
L
Site 34
S264
H
A
P
R
E
R
S
S
K
P
K
N
G
L
E
Site 35
S308
A
R
G
E
R
K
K
S
V
V
E
S
S
A
P
Site 36
S312
R
K
K
S
V
V
E
S
S
A
P
G
A
N
N
Site 37
S347
L
I
P
P
I
P
V
S
P
P
I
L
A
P
R
Site 38
S368
K
V
A
T
L
P
L
S
S
R
A
G
A
P
P
Site 39
S369
V
A
T
L
P
L
S
S
R
A
G
A
P
P
A
Site 40
T407
R
A
P
P
G
G
L
T
Q
P
R
G
T
E
N
Site 41
T412
G
L
T
Q
P
R
G
T
E
N
R
E
V
G
I
Site 42
S439
R
T
A
E
V
P
V
S
E
A
S
G
Q
A
P
Site 43
S460
Q
D
I
E
D
T
A
S
D
A
K
R
K
R
G
Site 44
S473
R
G
R
P
R
K
K
S
G
G
S
G
E
R
N
Site 45
S476
P
R
K
K
S
G
G
S
G
E
R
N
S
T
P
Site 46
S481
G
G
S
G
E
R
N
S
T
P
L
K
S
A
A
Site 47
T482
G
S
G
E
R
N
S
T
P
L
K
S
A
A
A
Site 48
S486
R
N
S
T
P
L
K
S
A
A
A
M
E
S
A
Site 49
S492
K
S
A
A
A
M
E
S
A
Q
S
S
R
L
P
Site 50
S495
A
A
M
E
S
A
Q
S
S
R
L
P
W
E
T
Site 51
S496
A
M
E
S
A
Q
S
S
R
L
P
W
E
T
W
Site 52
T502
S
S
R
L
P
W
E
T
W
G
S
G
G
E
G
Site 53
S505
L
P
W
E
T
W
G
S
G
G
E
G
N
S
A
Site 54
T538
A
Q
G
Q
G
D
G
T
V
S
K
G
G
R
G
Site 55
S540
G
Q
G
D
G
T
V
S
K
G
G
R
G
P
G
Site 56
S548
K
G
G
R
G
P
G
S
Q
H
T
K
E
A
E
Site 57
S566
P
L
V
P
S
K
V
S
V
I
K
G
S
R
S
Site 58
S573
S
V
I
K
G
S
R
S
Q
K
E
A
F
P
L
Site 59
S603
K
E
H
V
L
Q
S
S
L
S
Q
E
H
K
D
Site 60
S605
H
V
L
Q
S
S
L
S
Q
E
H
K
D
P
K
Site 61
T614
E
H
K
D
P
K
A
T
P
P
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation