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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX3
Full Name:
Transcription factor RFX3
Alias:
Regulatory factor X 3
Type:
Mass (Da):
83530
Number AA:
749
UniProt ID:
P48380
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
Q
T
S
E
T
G
S
D
T
G
S
T
V
T
Site 2
T10
T
S
E
T
G
S
D
T
G
S
T
V
T
L
Q
Site 3
S12
E
T
G
S
D
T
G
S
T
V
T
L
Q
T
S
Site 4
T13
T
G
S
D
T
G
S
T
V
T
L
Q
T
S
V
Site 5
T15
S
D
T
G
S
T
V
T
L
Q
T
S
V
A
S
Site 6
Y53
V
Q
Q
V
Q
H
V
Y
P
A
Q
V
Q
Y
V
Site 7
Y59
V
Y
P
A
Q
V
Q
Y
V
E
G
S
D
T
V
Site 8
S63
Q
V
Q
Y
V
E
G
S
D
T
V
Y
T
N
G
Site 9
T65
Q
Y
V
E
G
S
D
T
V
Y
T
N
G
A
I
Site 10
Y67
V
E
G
S
D
T
V
Y
T
N
G
A
I
R
T
Site 11
T75
T
N
G
A
I
R
T
T
T
Y
P
Y
T
E
T
Site 12
T76
N
G
A
I
R
T
T
T
Y
P
Y
T
E
T
Q
Site 13
Y77
G
A
I
R
T
T
T
Y
P
Y
T
E
T
Q
M
Site 14
T80
R
T
T
T
Y
P
Y
T
E
T
Q
M
Y
S
Q
Site 15
Y85
P
Y
T
E
T
Q
M
Y
S
Q
N
T
G
G
N
Site 16
Y93
S
Q
N
T
G
G
N
Y
F
D
T
Q
G
S
S
Site 17
T96
T
G
G
N
Y
F
D
T
Q
G
S
S
A
Q
V
Site 18
T104
Q
G
S
S
A
Q
V
T
T
V
V
S
S
H
S
Site 19
T105
G
S
S
A
Q
V
T
T
V
V
S
S
H
S
M
Site 20
Y135
I
S
S
S
G
G
T
Y
L
I
G
N
S
M
E
Site 21
S140
G
T
Y
L
I
G
N
S
M
E
N
S
G
H
S
Site 22
S144
I
G
N
S
M
E
N
S
G
H
S
V
T
H
T
Site 23
T151
S
G
H
S
V
T
H
T
T
R
A
S
P
A
T
Site 24
S155
V
T
H
T
T
R
A
S
P
A
T
I
E
M
A
Site 25
T158
T
T
R
A
S
P
A
T
I
E
M
A
I
E
T
Site 26
T165
T
I
E
M
A
I
E
T
L
Q
K
S
D
G
L
Site 27
S169
A
I
E
T
L
Q
K
S
D
G
L
S
T
H
R
Site 28
S173
L
Q
K
S
D
G
L
S
T
H
R
S
S
L
L
Site 29
T174
Q
K
S
D
G
L
S
T
H
R
S
S
L
L
N
Site 30
S177
D
G
L
S
T
H
R
S
S
L
L
N
S
H
L
Site 31
S178
G
L
S
T
H
R
S
S
L
L
N
S
H
L
Q
Site 32
S182
H
R
S
S
L
L
N
S
H
L
Q
W
L
L
D
Site 33
Y191
L
Q
W
L
L
D
N
Y
E
T
A
E
G
V
S
Site 34
S198
Y
E
T
A
E
G
V
S
L
P
R
S
T
L
Y
Site 35
S202
E
G
V
S
L
P
R
S
T
L
Y
N
H
Y
L
Site 36
T203
G
V
S
L
P
R
S
T
L
Y
N
H
Y
L
R
Site 37
Y205
S
L
P
R
S
T
L
Y
N
H
Y
L
R
H
C
Site 38
Y208
R
S
T
L
Y
N
H
Y
L
R
H
C
Q
E
H
Site 39
T238
S
I
F
M
G
L
R
T
R
R
L
G
T
R
G
Site 40
T243
L
R
T
R
R
L
G
T
R
G
N
S
K
Y
H
Site 41
S247
R
L
G
T
R
G
N
S
K
Y
H
Y
Y
G
I
Site 42
Y249
G
T
R
G
N
S
K
Y
H
Y
Y
G
I
R
V
Site 43
Y251
R
G
N
S
K
Y
H
Y
Y
G
I
R
V
K
P
Site 44
Y252
G
N
S
K
Y
H
Y
Y
G
I
R
V
K
P
D
Site 45
S260
G
I
R
V
K
P
D
S
P
L
N
R
L
Q
E
Site 46
Y271
R
L
Q
E
D
M
Q
Y
M
A
M
R
Q
Q
P
Site 47
T299
D
G
V
A
D
G
F
T
G
S
G
Q
Q
T
G
Site 48
S301
V
A
D
G
F
T
G
S
G
Q
Q
T
G
T
S
Site 49
T305
F
T
G
S
G
Q
Q
T
G
T
S
V
E
Q
T
Site 50
S308
S
G
Q
Q
T
G
T
S
V
E
Q
T
V
I
A
Site 51
T312
T
G
T
S
V
E
Q
T
V
I
A
Q
S
Q
H
Site 52
S327
H
Q
Q
F
L
D
A
S
R
A
L
P
E
F
G
Site 53
S339
E
F
G
E
V
E
I
S
S
L
P
D
G
T
T
Site 54
T346
S
S
L
P
D
G
T
T
F
E
D
I
K
S
L
Site 55
S352
T
T
F
E
D
I
K
S
L
Q
S
L
Y
R
E
Site 56
S355
E
D
I
K
S
L
Q
S
L
Y
R
E
H
C
E
Site 57
S387
W
Q
T
F
W
R
Y
S
P
S
T
P
T
D
G
Site 58
S389
T
F
W
R
Y
S
P
S
T
P
T
D
G
T
T
Site 59
T390
F
W
R
Y
S
P
S
T
P
T
D
G
T
T
I
Site 60
T395
P
S
T
P
T
D
G
T
T
I
T
E
S
S
N
Site 61
T396
S
T
P
T
D
G
T
T
I
T
E
S
S
N
L
Site 62
T398
P
T
D
G
T
T
I
T
E
S
S
N
L
S
E
Site 63
S400
D
G
T
T
I
T
E
S
S
N
L
S
E
I
E
Site 64
S404
I
T
E
S
S
N
L
S
E
I
E
S
R
L
P
Site 65
S408
S
N
L
S
E
I
E
S
R
L
P
K
A
K
L
Site 66
S465
A
I
R
N
F
A
K
S
L
E
G
W
L
S
N
Site 67
S471
K
S
L
E
G
W
L
S
N
A
M
N
N
I
P
Site 68
Y499
F
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Site 69
T500
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
Site 70
S501
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
A
Site 71
S517
R
A
V
L
Q
N
T
S
Q
I
N
Q
M
L
S
Site 72
T554
N
M
V
Q
R
L
E
T
D
F
K
M
T
L
Q
Site 73
S589
K
P
Y
E
G
R
P
S
F
P
K
A
A
R
Q
Site 74
Y636
L
Y
D
E
Y
M
F
Y
L
V
E
H
R
V
A
Site 75
T646
E
H
R
V
A
Q
A
T
G
E
T
P
I
A
V
Site 76
S664
F
G
D
L
N
A
V
S
P
G
N
L
D
K
D
Site 77
S674
N
L
D
K
D
E
G
S
E
V
E
S
E
M
D
Site 78
S678
D
E
G
S
E
V
E
S
E
M
D
E
E
L
D
Site 79
S687
M
D
E
E
L
D
D
S
S
E
P
Q
A
K
R
Site 80
S688
D
E
E
L
D
D
S
S
E
P
Q
A
K
R
E
Site 81
T697
P
Q
A
K
R
E
K
T
E
L
S
Q
A
F
P
Site 82
S700
K
R
E
K
T
E
L
S
Q
A
F
P
V
G
C
Site 83
S719
L
E
T
G
V
Q
P
S
L
L
N
P
I
H
S
Site 84
S726
S
L
L
N
P
I
H
S
E
H
I
V
T
S
T
Site 85
T731
I
H
S
E
H
I
V
T
S
T
Q
T
I
R
Q
Site 86
T735
H
I
V
T
S
T
Q
T
I
R
Q
C
S
A
T
Site 87
S740
T
Q
T
I
R
Q
C
S
A
T
G
N
T
Y
T
Site 88
T742
T
I
R
Q
C
S
A
T
G
N
T
Y
T
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation