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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ME1
Full Name:
NADP-dependent malic enzyme
Alias:
Malic enzyme 1
Type:
Mass (Da):
64150
Number AA:
572
UniProt ID:
P48163
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
E
A
P
R
R
R
H
T
H
Q
R
G
Y
L
L
Site 2
Y16
R
H
T
H
Q
R
G
Y
L
L
T
R
N
P
H
Site 3
T19
H
Q
R
G
Y
L
L
T
R
N
P
H
L
N
K
Site 4
S47
I
H
G
L
L
P
P
S
F
N
S
Q
E
I
Q
Site 5
S50
L
L
P
P
S
F
N
S
Q
E
I
Q
V
L
R
Site 6
S67
K
N
F
E
H
L
N
S
D
F
D
R
Y
L
L
Site 7
Y72
L
N
S
D
F
D
R
Y
L
L
L
M
D
L
Q
Site 8
Y87
D
R
N
E
K
L
F
Y
R
V
L
T
S
D
I
Site 9
Y113
V
G
L
A
C
Q
Q
Y
S
L
V
F
R
K
P
Site 10
S114
G
L
A
C
Q
Q
Y
S
L
V
F
R
K
P
R
Site 11
T126
K
P
R
G
L
F
I
T
I
H
D
R
G
H
I
Site 12
S135
H
D
R
G
H
I
A
S
V
L
N
A
W
P
E
Site 13
T197
P
V
I
L
D
V
G
T
E
N
E
E
L
L
K
Site 14
Y208
E
L
L
K
D
P
L
Y
I
G
L
R
Q
R
R
Site 15
S219
R
Q
R
R
V
R
G
S
E
Y
D
D
F
L
D
Site 16
Y221
R
R
V
R
G
S
E
Y
D
D
F
L
D
E
F
Site 17
Y259
A
F
R
L
L
N
K
Y
R
N
Q
Y
C
T
F
Site 18
Y263
L
N
K
Y
R
N
Q
Y
C
T
F
N
D
D
I
Site 19
T288
L
L
A
A
L
R
I
T
K
N
K
L
S
D
Q
Site 20
S293
R
I
T
K
N
K
L
S
D
Q
T
I
L
F
Q
Site 21
T296
K
N
K
L
S
D
Q
T
I
L
F
Q
G
A
G
Site 22
S336
K
K
I
W
L
V
D
S
K
G
L
I
V
K
G
Site 23
S346
L
I
V
K
G
R
A
S
L
T
Q
E
K
E
K
Site 24
T348
V
K
G
R
A
S
L
T
Q
E
K
E
K
F
A
Site 25
S407
R
P
I
I
F
A
L
S
N
P
T
S
K
A
E
Site 26
S411
F
A
L
S
N
P
T
S
K
A
E
C
S
A
E
Site 27
S432
K
G
R
A
I
F
A
S
G
S
P
F
D
P
V
Site 28
T440
G
S
P
F
D
P
V
T
L
P
N
G
Q
T
L
Site 29
T446
V
T
L
P
N
G
Q
T
L
Y
P
G
Q
G
N
Site 30
Y448
L
P
N
G
Q
T
L
Y
P
G
Q
G
N
N
S
Site 31
S455
Y
P
G
Q
G
N
N
S
Y
V
F
P
G
V
A
Site 32
Y456
P
G
Q
G
N
N
S
Y
V
F
P
G
V
A
L
Site 33
T474
A
C
G
L
R
Q
I
T
D
N
I
F
L
T
T
Site 34
Y500
H
L
E
E
G
R
L
Y
P
P
L
N
T
I
R
Site 35
S510
L
N
T
I
R
D
V
S
L
K
I
A
E
K
I
Site 36
Y522
E
K
I
V
K
D
A
Y
Q
E
K
T
A
T
V
Site 37
T526
K
D
A
Y
Q
E
K
T
A
T
V
Y
P
E
P
Site 38
T528
A
Y
Q
E
K
T
A
T
V
Y
P
E
P
Q
N
Site 39
Y530
Q
E
K
T
A
T
V
Y
P
E
P
Q
N
K
E
Site 40
S542
N
K
E
A
F
V
R
S
Q
M
Y
S
T
D
Y
Site 41
S546
F
V
R
S
Q
M
Y
S
T
D
Y
D
Q
I
L
Site 42
Y549
S
Q
M
Y
S
T
D
Y
D
Q
I
L
P
D
C
Site 43
Y557
D
Q
I
L
P
D
C
Y
S
W
P
E
E
V
Q
Site 44
S558
Q
I
L
P
D
C
Y
S
W
P
E
E
V
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation