KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CrkL
Full Name:
Crk-like protein
Alias:
CRKOL; V-crk sarcoma virus CT10 oncogene-like
Type:
Adapter/scaffold protein
Mass (Da):
33777
Number AA:
303
UniProt ID:
P46109
International Prot ID:
IPI00004839
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0007265
Phosida
TranscriptoNet
STRING
Kinexus Products
Crk-like protein (P248-T254, human) pY251 phosphopeptide - Powder PE-04AEQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEQ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
S
A
R
F
D
S
S
D
R
S
A
W
Y
Site 2
S9
S
S
A
R
F
D
S
S
D
R
S
A
W
Y
M
Site 3
S12
R
F
D
S
S
D
R
S
A
W
Y
M
G
P
V
Site 4
Y15
S
S
D
R
S
A
W
Y
M
G
P
V
S
R
Q
Site 5
S20
A
W
Y
M
G
P
V
S
R
Q
E
A
Q
T
R
Site 6
S41
G
M
F
L
V
R
D
S
S
T
C
P
G
D
Y
Site 7
S42
M
F
L
V
R
D
S
S
T
C
P
G
D
Y
V
Site 8
T43
F
L
V
R
D
S
S
T
C
P
G
D
Y
V
L
Site 9
Y48
S
S
T
C
P
G
D
Y
V
L
S
V
S
E
N
Site 10
S51
C
P
G
D
Y
V
L
S
V
S
E
N
S
R
V
Site 11
S53
G
D
Y
V
L
S
V
S
E
N
S
R
V
S
H
Site 12
S59
V
S
E
N
S
R
V
S
H
Y
I
I
N
S
L
Site 13
Y61
E
N
S
R
V
S
H
Y
I
I
N
S
L
P
N
Site 14
S65
V
S
H
Y
I
I
N
S
L
P
N
R
R
F
K
Site 15
Y92
L
E
F
Y
K
I
H
Y
L
D
T
T
T
L
I
Site 16
T95
Y
K
I
H
Y
L
D
T
T
T
L
I
E
P
A
Site 17
T96
K
I
H
Y
L
D
T
T
T
L
I
E
P
A
P
Site 18
Y105
L
I
E
P
A
P
R
Y
P
S
P
P
M
G
S
Site 19
S107
E
P
A
P
R
Y
P
S
P
P
M
G
S
V
S
Site 20
S112
Y
P
S
P
P
M
G
S
V
S
A
P
N
L
P
Site 21
S114
S
P
P
M
G
S
V
S
A
P
N
L
P
T
A
Site 22
Y127
T
A
E
D
N
L
E
Y
V
R
T
L
Y
D
F
Site 23
T130
D
N
L
E
Y
V
R
T
L
Y
D
F
P
G
N
Site 24
Y132
L
E
Y
V
R
T
L
Y
D
F
P
G
N
D
A
Site 25
S162
K
P
E
E
Q
W
W
S
A
R
N
K
D
G
R
Site 26
S184
Y
V
E
K
L
V
R
S
S
P
H
G
K
H
G
Site 27
S185
V
E
K
L
V
R
S
S
P
H
G
K
H
G
N
Site 28
S195
G
K
H
G
N
R
N
S
N
S
Y
G
I
P
E
Site 29
S197
H
G
N
R
N
S
N
S
Y
G
I
P
E
P
A
Site 30
Y198
G
N
R
N
S
N
S
Y
G
I
P
E
P
A
H
Site 31
Y207
I
P
E
P
A
H
A
Y
A
Q
P
Q
T
T
T
Site 32
T212
H
A
Y
A
Q
P
Q
T
T
T
P
L
P
A
V
Site 33
T213
A
Y
A
Q
P
Q
T
T
T
P
L
P
A
V
S
Site 34
T214
Y
A
Q
P
Q
T
T
T
P
L
P
A
V
S
G
Site 35
S220
T
T
P
L
P
A
V
S
G
S
P
G
A
A
I
Site 36
S222
P
L
P
A
V
S
G
S
P
G
A
A
I
T
P
Site 37
T228
G
S
P
G
A
A
I
T
P
L
P
S
T
Q
N
Site 38
S232
A
A
I
T
P
L
P
S
T
Q
N
G
P
V
F
Site 39
Y251
Q
K
R
V
P
C
A
Y
D
K
T
A
L
A
L
Crk-like protein (P248-T254, human) pY251 phosphopeptide - Powder PE-04AEQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEQ95
Site 40
T254
V
P
C
A
Y
D
K
T
A
L
A
L
E
V
G
Site 41
T289
R
K
G
L
F
P
F
T
H
V
K
I
F
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation