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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
5-HT (3) receptor ion channel
Full Name:
5-hydroxytryptamine receptor 3A
Alias:
5-hydroxytryptamine receptor 3;Serotonin receptor 3A;Serotonin-gated ion channel receptor
Type:
Channel protein
Mass (Da):
55280
Number AA:
478
UniProt ID:
P46098
International Prot ID:
IPI00748737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005887
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0051378
GO:0004993
GO:0005232
PhosphoSite+
KinaseNET
Biological Process:
GO:0007586
GO:0006811
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
A
Q
G
E
A
R
R
S
R
N
T
T
R
P
A
Site 2
T29
E
A
R
R
S
R
N
T
T
R
P
A
L
L
R
Site 3
T30
A
R
R
S
R
N
T
T
R
P
A
L
L
R
L
Site 4
S38
R
P
A
L
L
R
L
S
D
Y
L
L
T
N
Y
Site 5
Y40
A
L
L
R
L
S
D
Y
L
L
T
N
Y
R
K
Site 6
T43
R
L
S
D
Y
L
L
T
N
Y
R
K
G
V
R
Site 7
Y45
S
D
Y
L
L
T
N
Y
R
K
G
V
R
P
V
Site 8
T59
V
R
D
W
R
K
P
T
T
V
S
I
D
V
I
Site 9
T60
R
D
W
R
K
P
T
T
V
S
I
D
V
I
V
Site 10
T106
P
E
D
F
D
N
I
T
K
L
S
I
P
T
D
Site 11
S131
E
F
V
D
V
G
K
S
P
N
I
P
Y
V
Y
Site 12
Y136
G
K
S
P
N
I
P
Y
V
Y
I
R
H
Q
G
Site 13
Y138
S
P
N
I
P
Y
V
Y
I
R
H
Q
G
E
V
Site 14
Y148
H
Q
G
E
V
Q
N
Y
K
P
L
Q
V
V
T
Site 15
T181
T
F
T
S
W
L
H
T
I
Q
D
I
N
I
S
Site 16
S188
T
I
Q
D
I
N
I
S
L
W
R
L
P
E
K
Site 17
S198
R
L
P
E
K
V
K
S
D
R
S
V
F
M
N
Site 18
S201
E
K
V
K
S
D
R
S
V
F
M
N
Q
G
E
Site 19
S222
L
P
Y
F
R
E
F
S
M
E
S
S
N
Y
Y
Site 20
S226
R
E
F
S
M
E
S
S
N
Y
Y
A
E
M
K
Site 21
Y228
F
S
M
E
S
S
N
Y
Y
A
E
M
K
F
Y
Site 22
Y229
S
M
E
S
S
N
Y
Y
A
E
M
K
F
Y
V
Site 23
Y235
Y
Y
A
E
M
K
F
Y
V
V
I
R
R
R
P
Site 24
S270
G
F
Y
L
P
P
N
S
G
E
R
V
S
F
K
Site 25
S361
L
L
C
L
R
E
Q
S
T
S
Q
R
P
P
A
Site 26
T362
L
C
L
R
E
Q
S
T
S
Q
R
P
P
A
T
Site 27
S363
C
L
R
E
Q
S
T
S
Q
R
P
P
A
T
S
Site 28
S370
S
Q
R
P
P
A
T
S
Q
A
T
K
T
D
D
Site 29
T375
A
T
S
Q
A
T
K
T
D
D
C
S
A
M
G
Site 30
S397
G
P
Q
D
F
E
K
S
P
R
D
R
C
S
P
Site 31
S403
K
S
P
R
D
R
C
S
P
P
P
P
P
R
E
Site 32
S423
C
G
L
L
Q
E
L
S
S
I
R
Q
F
L
E
Site 33
S424
G
L
L
Q
E
L
S
S
I
R
Q
F
L
E
K
Site 34
Y457
D
K
L
L
F
H
I
Y
L
L
A
V
L
A
Y
Site 35
Y477
M
L
W
S
I
W
Q
Y
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation