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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PBEF
Full Name:
Nicotinamide phosphoribosyltransferase
Alias:
NAMPT; PBEF1; Pre-B cell enhancing factor precursor; Visfatin
Type:
Transferase; Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.12; Cytokine
Mass (Da):
55521
Number AA:
491
UniProt ID:
P43490
International Prot ID:
IPI00018873
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0047280
PhosphoSite+
KinaseNET
Biological Process:
GO:0019674
GO:0007267
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
E
F
N
I
L
L
A
T
D
S
Y
K
V
T
H
Site 2
S17
N
I
L
L
A
T
D
S
Y
K
V
T
H
Y
K
Site 3
Y18
I
L
L
A
T
D
S
Y
K
V
T
H
Y
K
Q
Site 4
T21
A
T
D
S
Y
K
V
T
H
Y
K
Q
Y
P
P
Site 5
Y23
D
S
Y
K
V
T
H
Y
K
Q
Y
P
P
N
T
Site 6
Y26
K
V
T
H
Y
K
Q
Y
P
P
N
T
S
K
V
Site 7
T30
Y
K
Q
Y
P
P
N
T
S
K
V
Y
S
Y
F
Site 8
S31
K
Q
Y
P
P
N
T
S
K
V
Y
S
Y
F
E
Site 9
Y34
P
P
N
T
S
K
V
Y
S
Y
F
E
C
R
E
Site 10
S35
P
N
T
S
K
V
Y
S
Y
F
E
C
R
E
K
Site 11
Y36
N
T
S
K
V
Y
S
Y
F
E
C
R
E
K
K
Site 12
T44
F
E
C
R
E
K
K
T
E
N
S
K
L
R
K
Site 13
S47
R
E
K
K
T
E
N
S
K
L
R
K
V
K
Y
Site 14
Y54
S
K
L
R
K
V
K
Y
E
E
T
V
F
Y
G
Site 15
T57
R
K
V
K
Y
E
E
T
V
F
Y
G
L
Q
Y
Site 16
Y60
K
Y
E
E
T
V
F
Y
G
L
Q
Y
I
L
N
Site 17
Y64
T
V
F
Y
G
L
Q
Y
I
L
N
K
Y
L
K
Site 18
Y69
L
Q
Y
I
L
N
K
Y
L
K
G
K
V
V
T
Site 19
Y87
I
Q
E
A
K
D
V
Y
K
E
H
F
Q
D
D
Site 20
Y108
W
N
Y
I
L
E
K
Y
D
G
H
L
P
I
E
Site 21
T133
P
R
G
N
V
L
F
T
V
E
N
T
D
P
E
Site 22
T160
V
Q
S
W
Y
P
I
T
V
A
T
N
S
R
E
Site 23
Y175
Q
K
K
I
L
A
K
Y
L
L
E
T
S
G
N
Site 24
Y188
G
N
L
D
G
L
E
Y
K
L
H
D
F
G
Y
Site 25
Y195
Y
K
L
H
D
F
G
Y
R
G
V
S
S
Q
E
Site 26
S199
D
F
G
Y
R
G
V
S
S
Q
E
T
A
G
I
Site 27
S200
F
G
Y
R
G
V
S
S
Q
E
T
A
G
I
G
Site 28
T203
R
G
V
S
S
Q
E
T
A
G
I
G
A
S
A
Site 29
Y231
L
A
L
I
K
K
Y
Y
G
T
K
D
P
V
P
Site 30
T233
L
I
K
K
Y
Y
G
T
K
D
P
V
P
G
Y
Site 31
Y240
T
K
D
P
V
P
G
Y
S
V
P
A
A
E
H
Site 32
S241
K
D
P
V
P
G
Y
S
V
P
A
A
E
H
S
Site 33
S275
Q
F
S
S
V
P
V
S
V
V
S
D
S
Y
D
Site 34
S278
S
V
P
V
S
V
V
S
D
S
Y
D
I
Y
N
Site 35
Y281
V
S
V
V
S
D
S
Y
D
I
Y
N
A
C
E
Site 36
Y284
V
S
D
S
Y
D
I
Y
N
A
C
E
K
I
W
Site 37
S301
D
L
R
H
L
I
V
S
R
S
T
Q
A
P
L
Site 38
S314
P
L
I
I
R
P
D
S
G
N
P
L
D
T
V
Site 39
T335
L
G
K
K
F
P
V
T
E
N
S
K
G
Y
K
Site 40
S338
K
F
P
V
T
E
N
S
K
G
Y
K
L
L
P
Site 41
Y347
G
Y
K
L
L
P
P
Y
L
R
V
I
Q
G
D
Site 42
T360
G
D
G
V
D
I
N
T
L
Q
E
I
V
E
G
Site 43
S382
I
E
N
I
A
F
G
S
G
G
G
L
L
Q
K
Site 44
T391
G
G
L
L
Q
K
L
T
R
D
L
L
N
C
S
Site 45
S398
T
R
D
L
L
N
C
S
F
K
C
S
Y
V
V
Site 46
S431
R
S
K
K
G
R
L
S
L
H
R
T
P
A
G
Site 47
T435
G
R
L
S
L
H
R
T
P
A
G
N
F
V
T
Site 48
Y453
G
K
G
D
L
E
E
Y
G
Q
D
L
L
H
T
Site 49
T460
Y
G
Q
D
L
L
H
T
V
F
K
N
G
K
V
Site 50
S470
K
N
G
K
V
T
K
S
Y
S
F
D
E
I
R
Site 51
Y471
N
G
K
V
T
K
S
Y
S
F
D
E
I
R
K
Site 52
S472
G
K
V
T
K
S
Y
S
F
D
E
I
R
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation