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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN9
Full Name:
Tyrosine-protein phosphatase non-receptor type 9
Alias:
EC 3.1.3.48; MEG2; Protein-tyrosine phosphatase meg2; Protein-tyrosine phosphatase MEG2, PTPase-MEG2; Ptn9; Ptpase-meg2; Tyrosine-protein phosphatase non-receptor type 9
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
68020
Number AA:
593
UniProt ID:
P43378
International Prot ID:
IPI00018116
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004726
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
P
D
M
A
P
E
L
T
P
E
E
E
Q
A
T
Site 2
Y37
I
N
K
W
T
V
Q
Y
N
V
S
P
L
S
W
Site 3
S67
R
A
I
E
L
F
H
S
Y
R
E
T
R
R
K
Site 4
T71
L
F
H
S
Y
R
E
T
R
R
K
E
G
I
V
Site 5
S89
P
H
E
E
P
L
R
S
E
I
L
S
G
K
F
Site 6
T97
E
I
L
S
G
K
F
T
I
L
N
V
R
D
P
Site 7
Y133
V
V
L
Q
A
L
F
Y
L
L
D
R
A
V
D
Site 8
S141
L
L
D
R
A
V
D
S
F
E
T
Q
R
N
G
Site 9
T144
R
A
V
D
S
F
E
T
Q
R
N
G
L
V
F
Site 10
Y153
R
N
G
L
V
F
I
Y
D
M
C
G
S
N
Y
Site 11
Y160
Y
D
M
C
G
S
N
Y
A
N
F
E
L
D
L
Site 12
T219
E
R
I
Q
I
L
K
T
S
E
V
T
Q
H
L
Site 13
S277
P
P
A
L
D
W
D
S
V
H
V
P
G
P
H
Site 14
Y294
T
I
Q
E
L
V
D
Y
V
N
A
R
Q
K
Q
Site 15
Y304
A
R
Q
K
Q
G
I
Y
E
E
Y
E
D
I
R
Site 16
Y307
K
Q
G
I
Y
E
E
Y
E
D
I
R
R
E
N
Site 17
T318
R
R
E
N
P
V
G
T
F
H
C
S
M
S
P
Site 18
S322
P
V
G
T
F
H
C
S
M
S
P
G
N
L
E
Site 19
S324
G
T
F
H
C
S
M
S
P
G
N
L
E
K
N
Site 20
Y333
G
N
L
E
K
N
R
Y
G
D
V
P
C
L
D
Site 21
T342
D
V
P
C
L
D
Q
T
R
V
K
L
T
K
R
Site 22
Y357
S
G
H
T
Q
T
D
Y
I
N
A
S
F
M
D
Site 23
Y366
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Site 24
Y372
G
Y
K
Q
K
N
A
Y
I
G
T
Q
G
P
L
Site 25
T375
Q
K
N
A
Y
I
G
T
Q
G
P
L
E
N
T
Site 26
Y383
Q
G
P
L
E
N
T
Y
R
D
F
W
L
M
V
Site 27
Y415
G
R
R
K
C
G
Q
Y
W
P
L
E
K
D
S
Site 28
T452
T
T
L
E
I
H
N
T
E
E
R
Q
K
R
Q
Site 29
T461
E
R
Q
K
R
Q
V
T
H
F
Q
F
L
S
W
Site 30
Y471
Q
F
L
S
W
P
D
Y
G
V
P
S
S
A
A
Site 31
S475
W
P
D
Y
G
V
P
S
S
A
A
S
L
I
D
Site 32
S492
R
V
V
R
N
Q
Q
S
L
A
V
S
N
M
G
Site 33
S496
N
Q
Q
S
L
A
V
S
N
M
G
A
R
S
K
Site 34
S502
V
S
N
M
G
A
R
S
K
G
Q
C
P
E
P
Site 35
T546
G
T
L
N
V
F
Q
T
V
S
R
M
R
T
Q
Site 36
S548
L
N
V
F
Q
T
V
S
R
M
R
T
Q
R
A
Site 37
T552
Q
T
V
S
R
M
R
T
Q
R
A
F
S
I
Q
Site 38
S557
M
R
T
Q
R
A
F
S
I
Q
T
P
E
Q
Y
Site 39
T560
Q
R
A
F
S
I
Q
T
P
E
Q
Y
Y
F
C
Site 40
Y565
I
Q
T
P
E
Q
Y
Y
F
C
Y
K
A
I
L
Site 41
Y568
P
E
Q
Y
Y
F
C
Y
K
A
I
L
E
F
A
Site 42
S583
E
K
E
G
M
V
S
S
G
Q
N
L
L
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation