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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GDF5
Full Name:
Growth/differentiation factor 5
Alias:
Cartilage-derived morphogenetic protein 1;Radotermin
Type:
Mass (Da):
55411
Number AA:
501
UniProt ID:
P43026
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
V
F
R
P
G
G
H
S
Y
G
G
G
A
T
N
Site 2
T87
T
G
Q
T
G
G
L
T
Q
P
K
K
D
E
P
Site 3
T118
P
P
Q
T
R
Q
A
T
A
R
T
V
T
P
K
Site 4
T121
T
R
Q
A
T
A
R
T
V
T
P
K
G
Q
L
Site 5
T123
Q
A
T
A
R
T
V
T
P
K
G
Q
L
P
G
Site 6
S139
K
A
P
P
K
A
G
S
V
P
S
S
F
L
L
Site 7
S143
K
A
G
S
V
P
S
S
F
L
L
K
K
A
R
Site 8
T168
P
F
R
P
P
P
I
T
P
H
E
Y
M
L
S
Site 9
S175
T
P
H
E
Y
M
L
S
L
Y
R
T
L
S
D
Site 10
Y177
H
E
Y
M
L
S
L
Y
R
T
L
S
D
A
D
Site 11
T179
Y
M
L
S
L
Y
R
T
L
S
D
A
D
R
K
Site 12
S181
L
S
L
Y
R
T
L
S
D
A
D
R
K
G
G
Site 13
S190
A
D
R
K
G
G
N
S
S
V
K
L
E
A
G
Site 14
S191
D
R
K
G
G
N
S
S
V
K
L
E
A
G
L
Site 15
S204
G
L
A
N
T
I
T
S
F
I
D
K
G
Q
D
Site 16
S247
R
I
L
R
K
K
P
S
D
T
A
K
P
A
A
Site 17
T249
L
R
K
K
P
S
D
T
A
K
P
A
A
P
G
Site 18
S266
R
A
A
Q
L
K
L
S
S
C
P
S
G
R
Q
Site 19
S267
A
A
Q
L
K
L
S
S
C
P
S
G
R
Q
P
Site 20
S270
L
K
L
S
S
C
P
S
G
R
Q
P
A
S
L
Site 21
S276
P
S
G
R
Q
P
A
S
L
L
D
V
R
S
V
Site 22
T368
R
S
G
Q
D
D
K
T
V
Y
E
Y
L
F
S
Site 23
Y370
G
Q
D
D
K
T
V
Y
E
Y
L
F
S
Q
R
Site 24
Y372
D
D
K
T
V
Y
E
Y
L
F
S
Q
R
R
K
Site 25
S375
T
V
Y
E
Y
L
F
S
Q
R
R
K
R
R
A
Site 26
T386
K
R
R
A
P
L
A
T
R
Q
G
K
R
P
S
Site 27
S393
T
R
Q
G
K
R
P
S
K
N
L
K
A
R
C
Site 28
S401
K
N
L
K
A
R
C
S
R
K
A
L
H
V
N
Site 29
T451
T
N
H
A
V
I
Q
T
L
M
N
S
M
D
P
Site 30
S455
V
I
Q
T
L
M
N
S
M
D
P
E
S
T
P
Site 31
T461
N
S
M
D
P
E
S
T
P
P
T
C
C
V
P
Site 32
T464
D
P
E
S
T
P
P
T
C
C
V
P
T
R
L
Site 33
S472
C
C
V
P
T
R
L
S
P
I
S
I
L
F
I
Site 34
S475
P
T
R
L
S
P
I
S
I
L
F
I
D
S
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation