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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTHFR
Full Name:
Methylenetetrahydrofolate reductase
Alias:
Type:
Mass (Da):
74597
Number AA:
656
UniProt ID:
P42898
International Prot ID:
IPI00002487
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004489
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008015
GO:0006555
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
N
E
A
R
G
N
S
S
L
N
P
C
L
E
Site 2
S10
N
E
A
R
G
N
S
S
L
N
P
C
L
E
G
Site 3
S18
L
N
P
C
L
E
G
S
A
S
S
G
S
E
S
Site 4
S20
P
C
L
E
G
S
A
S
S
G
S
E
S
S
K
Site 5
S21
C
L
E
G
S
A
S
S
G
S
E
S
S
K
D
Site 6
S23
E
G
S
A
S
S
G
S
E
S
S
K
D
S
S
Site 7
S25
S
A
S
S
G
S
E
S
S
K
D
S
S
R
C
Site 8
S26
A
S
S
G
S
E
S
S
K
D
S
S
R
C
S
Site 9
S29
G
S
E
S
S
K
D
S
S
R
C
S
T
P
G
Site 10
S30
S
E
S
S
K
D
S
S
R
C
S
T
P
G
L
Site 11
S33
S
K
D
S
S
R
C
S
T
P
G
L
D
P
E
Site 12
T34
K
D
S
S
R
C
S
T
P
G
L
D
P
E
R
Site 13
S55
K
M
R
R
R
L
E
S
G
D
K
W
F
S
L
Site 14
S61
E
S
G
D
K
W
F
S
L
E
F
F
P
P
R
Site 15
Y90
M
A
A
G
G
P
L
Y
I
D
V
T
W
H
P
Site 16
T94
G
P
L
Y
I
D
V
T
W
H
P
A
G
D
P
Site 17
S103
H
P
A
G
D
P
G
S
D
K
E
T
S
S
M
Site 18
T107
D
P
G
S
D
K
E
T
S
S
M
M
I
A
S
Site 19
S109
G
S
D
K
E
T
S
S
M
M
I
A
S
T
A
Site 20
Y174
E
E
E
G
G
F
N
Y
A
V
D
L
V
K
H
Site 21
Y197
F
D
I
C
V
A
G
Y
P
K
G
H
P
E
A
Site 22
S206
K
G
H
P
E
A
G
S
F
E
A
D
L
K
H
Site 23
S264
F
P
I
Q
G
Y
H
S
L
R
Q
L
V
K
L
Site 24
S272
L
R
Q
L
V
K
L
S
K
L
E
V
P
Q
E
Site 25
T322
V
P
G
L
H
F
Y
T
L
N
R
E
M
A
T
Site 26
T329
T
L
N
R
E
M
A
T
T
E
V
L
K
R
L
Site 27
T330
L
N
R
E
M
A
T
T
E
V
L
K
R
L
G
Site 28
T340
L
K
R
L
G
M
W
T
E
D
P
R
R
P
L
Site 29
S352
R
P
L
P
W
A
L
S
A
H
P
K
R
R
E
Site 30
S373
F
W
A
S
R
P
K
S
Y
I
Y
R
T
Q
E
Site 31
S392
P
N
G
R
W
G
N
S
S
S
P
A
F
G
E
Site 32
S393
N
G
R
W
G
N
S
S
S
P
A
F
G
E
L
Site 33
S394
G
R
W
G
N
S
S
S
P
A
F
G
E
L
K
Site 34
Y403
A
F
G
E
L
K
D
Y
Y
L
F
Y
L
K
S
Site 35
Y404
F
G
E
L
K
D
Y
Y
L
F
Y
L
K
S
K
Site 36
Y407
L
K
D
Y
Y
L
F
Y
L
K
S
K
S
P
K
Site 37
S410
Y
Y
L
F
Y
L
K
S
K
S
P
K
E
E
L
Site 38
S412
L
F
Y
L
K
S
K
S
P
K
E
E
L
L
K
Site 39
S427
M
W
G
E
E
L
T
S
E
E
S
V
F
E
V
Site 40
S440
E
V
F
V
L
Y
L
S
G
E
P
N
R
N
G
Site 41
T481
V
N
R
Q
G
I
L
T
I
N
S
Q
P
N
I
Site 42
S484
Q
G
I
L
T
I
N
S
Q
P
N
I
N
G
K
Site 43
S494
N
I
N
G
K
P
S
S
D
P
I
V
G
W
G
Site 44
S503
P
I
V
G
W
G
P
S
G
G
Y
V
F
Q
K
Site 45
Y506
G
W
G
P
S
G
G
Y
V
F
Q
K
A
Y
L
Site 46
Y512
G
Y
V
F
Q
K
A
Y
L
E
F
F
T
S
R
Site 47
S518
A
Y
L
E
F
F
T
S
R
E
T
A
E
A
L
Site 48
T521
E
F
F
T
S
R
E
T
A
E
A
L
L
Q
V
Site 49
Y532
L
L
Q
V
L
K
K
Y
E
L
R
V
N
Y
H
Site 50
Y538
K
Y
E
L
R
V
N
Y
H
L
V
N
V
K
G
Site 51
T549
N
V
K
G
E
N
I
T
N
A
P
E
L
Q
P
Site 52
Y599
I
E
R
W
G
K
L
Y
E
E
E
S
P
S
R
Site 53
S603
G
K
L
Y
E
E
E
S
P
S
R
T
I
I
Q
Site 54
S605
L
Y
E
E
E
S
P
S
R
T
I
I
Q
Y
I
Site 55
T607
E
E
E
S
P
S
R
T
I
I
Q
Y
I
H
D
Site 56
Y611
P
S
R
T
I
I
Q
Y
I
H
D
N
Y
F
L
Site 57
T639
L
W
Q
V
V
E
D
T
L
E
L
L
N
R
P
Site 58
T647
L
E
L
L
N
R
P
T
Q
N
A
R
E
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation