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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXK
Full Name:
Tyrosine-protein kinase TXK
Alias:
EC 2.7.1.112; EC 2.7.10.2
Type:
Protein-serine kinase, TK group, Tec family
Mass (Da):
61258
Number AA:
527
UniProt ID:
P42681
International Prot ID:
IPI00000879
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Tyrosine-protein kinase TXK Y420 phosphosite-specific antibody AB-PK844#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK844#Tyrosine-protein kinase TXK (D417-S423, human) pY420 phosphopeptide - Powder PE-04AQI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQI99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
R
Q
M
R
T
Q
I
S
L
S
T
D
E
E
L
Site 2
S33
M
R
T
Q
I
S
L
S
T
D
E
E
L
P
E
Site 3
Y42
D
E
E
L
P
E
K
Y
T
Q
R
R
R
P
W
Site 4
T43
E
E
L
P
E
K
Y
T
Q
R
R
R
P
W
L
Site 5
S51
Q
R
R
R
P
W
L
S
Q
L
S
N
K
K
Q
Site 6
S54
R
P
W
L
S
Q
L
S
N
K
K
Q
S
N
T
Site 7
T61
S
N
K
K
Q
S
N
T
G
R
V
Q
P
S
K
Site 8
S67
N
T
G
R
V
Q
P
S
K
R
K
P
L
P
P
Site 9
S78
P
L
P
P
L
P
P
S
E
V
A
E
E
K
I
Site 10
Y91
K
I
Q
V
K
A
L
Y
D
F
L
P
R
E
P
Site 11
Y109
A
L
R
R
A
E
E
Y
L
I
L
E
K
Y
N
Site 12
S134
G
N
E
G
L
I
P
S
N
Y
V
T
E
N
K
Site 13
Y136
E
G
L
I
P
S
N
Y
V
T
E
N
K
I
T
Site 14
T138
L
I
P
S
N
Y
V
T
E
N
K
I
T
N
L
Site 15
Y148
K
I
T
N
L
E
I
Y
E
W
Y
H
R
N
I
Site 16
Y151
N
L
E
I
Y
E
W
Y
H
R
N
I
T
R
N
Site 17
S168
E
H
L
L
R
Q
E
S
K
E
G
A
F
I
V
Site 18
S178
G
A
F
I
V
R
D
S
R
H
L
G
S
Y
T
Site 19
S183
R
D
S
R
H
L
G
S
Y
T
I
S
V
F
M
Site 20
Y184
D
S
R
H
L
G
S
Y
T
I
S
V
F
M
G
Site 21
S195
V
F
M
G
A
R
R
S
T
E
A
A
I
K
H
Site 22
T196
F
M
G
A
R
R
S
T
E
A
A
I
K
H
Y
Site 23
Y214
K
N
D
S
G
Q
W
Y
V
A
E
R
H
A
F
Site 24
Y230
S
I
P
E
L
I
W
Y
H
Q
H
N
A
A
G
Site 25
T256
M
G
S
C
L
P
A
T
A
G
F
S
Y
E
K
Site 26
S269
E
K
W
E
I
D
P
S
E
L
A
F
I
K
E
Site 27
S305
I
K
A
I
N
E
G
S
M
S
E
E
D
F
I
Site 28
S307
A
I
N
E
G
S
M
S
E
E
D
F
I
E
E
Site 29
Y330
H
S
K
L
V
Q
L
Y
G
V
C
I
Q
R
K
Site 30
Y354
E
N
G
C
L
L
N
Y
L
R
E
N
K
G
K
Site 31
Y380
D
I
C
E
G
M
E
Y
L
E
R
N
G
Y
I
Site 32
Y386
E
Y
L
E
R
N
G
Y
I
H
R
D
L
A
A
Site 33
Y414
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
V
Site 34
Y420
R
Y
V
L
D
D
E
Y
V
S
S
F
G
A
K
Tyrosine-protein kinase TXK Y420 phosphosite-specific antibody AB-PK844#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK844#Tyrosine-protein kinase TXK (D417-S423, human) pY420 phosphopeptide - Powder PE-04AQI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQI99
Site 35
S423
L
D
D
E
Y
V
S
S
F
G
A
K
F
P
I
Site 36
Y443
E
V
F
L
F
N
K
Y
S
S
K
S
D
V
W
Site 37
S444
V
F
L
F
N
K
Y
S
S
K
S
D
V
W
S
Site 38
S445
F
L
F
N
K
Y
S
S
K
S
D
V
W
S
F
Site 39
S447
F
N
K
Y
S
S
K
S
D
V
W
S
F
G
V
Site 40
S451
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
Site 41
Y486
I
S
E
G
F
R
L
Y
R
P
H
L
A
P
M
Site 42
S494
R
P
H
L
A
P
M
S
I
Y
E
V
M
Y
S
Site 43
T512
E
K
P
E
G
R
P
T
F
A
E
L
L
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation