KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HAL
Full Name:
Histidine ammonia-lyase
Alias:
HIS; Histidase; HUTH
Type:
Lyase; Energy Metabolism - nitrogen; Amino Acid Metabolism - histidine; EC 4.3.1.3
Mass (Da):
72679
Number AA:
657
UniProt ID:
P42357
International Prot ID:
IPI00031425
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0016211
GO:0004397
PhosphoSite+
KinaseNET
Biological Process:
GO:0009058
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
P
C
Q
D
A
Q
L
T
V
G
W
L
G
R
E
Site 2
Y35
G
R
E
A
V
R
R
Y
I
K
N
K
P
D
N
Site 3
S47
P
D
N
G
G
F
T
S
V
D
D
A
H
F
L
Site 4
S90
V
I
E
G
D
A
M
S
P
D
F
I
P
S
Q
Site 5
S96
M
S
P
D
F
I
P
S
Q
P
E
G
V
Y
L
Site 6
Y102
P
S
Q
P
E
G
V
Y
L
Y
S
K
Y
R
E
Site 7
S105
P
E
G
V
Y
L
Y
S
K
Y
R
E
P
E
K
Site 8
Y107
G
V
Y
L
Y
S
K
Y
R
E
P
E
K
Y
I
Site 9
Y113
K
Y
R
E
P
E
K
Y
I
E
L
D
G
D
R
Site 10
T122
E
L
D
G
D
R
L
T
T
E
D
L
V
N
L
Site 11
T123
L
D
G
D
R
L
T
T
E
D
L
V
N
L
G
Site 12
T139
G
R
Y
K
I
K
L
T
P
T
A
E
K
R
V
Site 13
S155
K
S
R
E
V
I
D
S
I
I
K
E
K
T
V
Site 14
S193
L
Q
V
N
L
V
R
S
H
S
S
G
V
G
K
Site 15
S195
V
N
L
V
R
S
H
S
S
G
V
G
K
P
L
Site 16
S196
N
L
V
R
S
H
S
S
G
V
G
K
P
L
S
Site 17
S203
S
G
V
G
K
P
L
S
P
E
R
C
R
M
L
Site 18
S226
A
K
G
Y
S
G
I
S
L
E
T
L
K
Q
V
Site 19
T250
P
Y
V
P
E
K
G
T
V
G
A
S
G
D
L
Site 20
S275
V
G
E
G
K
M
W
S
P
K
S
G
W
A
D
Site 21
Y285
S
G
W
A
D
A
K
Y
V
L
E
A
H
G
L
Site 22
S324
C
E
A
V
E
R
A
S
A
I
A
R
Q
A
D
Site 23
T337
A
D
I
V
A
A
L
T
L
E
V
L
K
G
T
Site 24
T350
G
T
T
K
A
F
D
T
D
I
H
A
L
R
P
Site 25
S370
E
V
A
F
R
F
R
S
L
L
D
S
D
H
H
Site 26
S374
R
F
R
S
L
L
D
S
D
H
H
P
S
E
I
Site 27
S379
L
D
S
D
H
H
P
S
E
I
A
E
S
H
R
Site 28
S384
H
P
S
E
I
A
E
S
H
R
F
C
D
R
V
Site 29
Y395
C
D
R
V
Q
D
A
Y
T
L
R
C
C
P
Q
Site 30
T396
D
R
V
Q
D
A
Y
T
L
R
C
C
P
Q
V
Site 31
T438
V
F
A
N
R
G
E
T
V
S
G
G
N
F
H
Site 32
S440
A
N
R
G
E
T
V
S
G
G
N
F
H
G
E
Site 33
Y448
G
G
N
F
H
G
E
Y
P
A
K
A
L
D
Y
Site 34
S467
I
H
E
L
A
A
I
S
E
R
R
I
E
R
L
Site 35
S517
N
K
A
L
C
H
P
S
S
V
D
S
L
S
T
Site 36
S518
K
A
L
C
H
P
S
S
V
D
S
L
S
T
S
Site 37
S521
C
H
P
S
S
V
D
S
L
S
T
S
A
A
T
Site 38
S523
P
S
S
V
D
S
L
S
T
S
A
A
T
E
D
Site 39
S525
S
V
D
S
L
S
T
S
A
A
T
E
D
H
V
Site 40
S533
A
A
T
E
D
H
V
S
M
G
G
W
A
A
R
Site 41
T572
E
F
L
R
P
L
K
T
T
T
P
L
E
K
V
Site 42
T574
L
R
P
L
K
T
T
T
P
L
E
K
V
Y
D
Site 43
S585
K
V
Y
D
L
V
R
S
V
V
R
P
W
I
K
Site 44
Y623
A
A
P
Y
I
E
K
Y
R
M
E
H
I
P
E
Site 45
S631
R
M
E
H
I
P
E
S
R
P
L
S
P
T
A
Site 46
S635
I
P
E
S
R
P
L
S
P
T
A
F
S
L
Q
Site 47
T637
E
S
R
P
L
S
P
T
A
F
S
L
Q
F
L
Site 48
S640
P
L
S
P
T
A
F
S
L
Q
F
L
H
K
K
Site 49
S648
L
Q
F
L
H
K
K
S
T
K
I
P
E
S
E
Site 50
T649
Q
F
L
H
K
K
S
T
K
I
P
E
S
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation