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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP25
Full Name:
Rho GTPase-activating protein 25
Alias:
KIAA0053; RHG25; Rho GTPase activating protein 25; Rho-type GTPase-activating protein 25
Type:
Mass (Da):
73417
Number AA:
645
UniProt ID:
P42331
International Prot ID:
IPI00383530
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
K
I
A
R
S
R
S
V
M
T
G
E
Q
M
Site 2
S39
M
A
A
F
H
P
S
S
T
P
N
P
L
E
R
Site 3
T40
A
A
F
H
P
S
S
T
P
N
P
L
E
R
P
Site 4
Y67
V
K
N
W
Q
Q
R
Y
F
V
L
R
A
Q
Q
Site 5
Y76
V
L
R
A
Q
Q
L
Y
Y
Y
K
D
E
E
D
Site 6
Y78
R
A
Q
Q
L
Y
Y
Y
K
D
E
E
D
T
K
Site 7
Y91
T
K
P
Q
G
C
M
Y
L
P
G
C
T
I
K
Site 8
S128
Q
N
R
M
G
Q
D
S
Y
V
L
M
A
S
S
Site 9
Y129
N
R
M
G
Q
D
S
Y
V
L
M
A
S
S
Q
Site 10
S135
S
Y
V
L
M
A
S
S
Q
A
E
M
E
E
W
Site 11
T164
F
G
Q
R
L
D
E
T
V
A
Y
E
Q
K
F
Site 12
Y167
R
L
D
E
T
V
A
Y
E
Q
K
F
G
P
H
Site 13
S221
F
D
A
G
E
R
P
S
F
D
R
D
T
D
V
Site 14
T226
R
P
S
F
D
R
D
T
D
V
H
T
V
A
S
Site 15
T230
D
R
D
T
D
V
H
T
V
A
S
L
L
K
L
Site 16
S233
T
D
V
H
T
V
A
S
L
L
K
L
Y
L
R
Site 17
S250
P
E
P
V
V
P
W
S
Q
Y
E
G
F
L
L
Site 18
S278
Q
E
L
M
K
Q
L
S
I
L
P
R
D
N
Y
Site 19
S286
I
L
P
R
D
N
Y
S
L
L
S
Y
I
C
R
Site 20
Y290
D
N
Y
S
L
L
S
Y
I
C
R
F
L
H
E
Site 21
T335
P
A
V
I
M
R
G
T
P
Q
I
Q
R
V
M
Site 22
S356
H
E
V
L
F
P
K
S
K
D
I
P
L
S
P
Site 23
S362
K
S
K
D
I
P
L
S
P
P
A
Q
K
N
D
Site 24
S378
K
K
A
P
V
A
R
S
S
V
G
W
D
A
T
Site 25
S379
K
A
P
V
A
R
S
S
V
G
W
D
A
T
E
Site 26
T385
S
S
V
G
W
D
A
T
E
D
L
R
I
S
R
Site 27
S391
A
T
E
D
L
R
I
S
R
T
D
S
F
S
S
Site 28
T393
E
D
L
R
I
S
R
T
D
S
F
S
S
M
T
Site 29
S395
L
R
I
S
R
T
D
S
F
S
S
M
T
S
D
Site 30
S397
I
S
R
T
D
S
F
S
S
M
T
S
D
S
D
Site 31
S398
S
R
T
D
S
F
S
S
M
T
S
D
S
D
T
Site 32
T400
T
D
S
F
S
S
M
T
S
D
S
D
T
T
S
Site 33
S401
D
S
F
S
S
M
T
S
D
S
D
T
T
S
P
Site 34
S403
F
S
S
M
T
S
D
S
D
T
T
S
P
T
G
Site 35
T405
S
M
T
S
D
S
D
T
T
S
P
T
G
Q
Q
Site 36
S407
T
S
D
S
D
T
T
S
P
T
G
Q
Q
P
S
Site 37
S414
S
P
T
G
Q
Q
P
S
D
A
F
P
E
D
S
Site 38
S422
D
A
F
P
E
D
S
S
K
V
P
R
E
K
P
Site 39
S436
P
G
D
W
K
M
Q
S
R
K
R
T
Q
T
L
Site 40
T440
K
M
Q
S
R
K
R
T
Q
T
L
P
N
R
K
Site 41
T442
Q
S
R
K
R
T
Q
T
L
P
N
R
K
C
F
Site 42
T451
P
N
R
K
C
F
L
T
S
A
F
Q
G
A
N
Site 43
S460
A
F
Q
G
A
N
S
S
K
M
E
I
F
K
N
Site 44
S471
I
F
K
N
E
F
W
S
P
S
S
E
A
K
A
Site 45
S473
K
N
E
F
W
S
P
S
S
E
A
K
A
G
E
Site 46
S474
N
E
F
W
S
P
S
S
E
A
K
A
G
E
G
Site 47
T485
A
G
E
G
H
R
R
T
M
S
Q
D
L
R
Q
Site 48
S487
E
G
H
R
R
T
M
S
Q
D
L
R
Q
L
S
Site 49
S494
S
Q
D
L
R
Q
L
S
D
S
Q
R
T
S
T
Site 50
S496
D
L
R
Q
L
S
D
S
Q
R
T
S
T
Y
D
Site 51
S500
L
S
D
S
Q
R
T
S
T
Y
D
N
V
P
S
Site 52
T501
S
D
S
Q
R
T
S
T
Y
D
N
V
P
S
L
Site 53
Y502
D
S
Q
R
T
S
T
Y
D
N
V
P
S
L
P
Site 54
S507
S
T
Y
D
N
V
P
S
L
P
G
S
P
G
E
Site 55
S511
N
V
P
S
L
P
G
S
P
G
E
E
A
S
A
Site 56
S517
G
S
P
G
E
E
A
S
A
L
S
S
Q
A
C
Site 57
S520
G
E
E
A
S
A
L
S
S
Q
A
C
D
S
K
Site 58
S521
E
E
A
S
A
L
S
S
Q
A
C
D
S
K
G
Site 59
S526
L
S
S
Q
A
C
D
S
K
G
D
T
L
A
S
Site 60
T530
A
C
D
S
K
G
D
T
L
A
S
P
N
S
E
Site 61
S533
S
K
G
D
T
L
A
S
P
N
S
E
T
G
P
Site 62
S536
D
T
L
A
S
P
N
S
E
T
G
P
G
K
K
Site 63
S545
T
G
P
G
K
K
N
S
G
E
E
E
I
D
S
Site 64
S552
S
G
E
E
E
I
D
S
L
Q
R
M
V
Q
E
Site 65
Y571
I
E
T
Q
K
Q
M
Y
E
E
Q
I
K
N
L
Site 66
Y583
K
N
L
E
K
E
N
Y
D
V
W
A
K
V
V
Site 67
S603
L
E
K
E
K
K
K
S
A
A
L
E
I
S
L
Site 68
S609
K
S
A
A
L
E
I
S
L
R
N
M
E
R
S
Site 69
S616
S
L
R
N
M
E
R
S
R
E
D
V
E
K
R
Site 70
S637
E
V
K
E
F
V
K
S
M
K
E
P
K
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation