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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT6
Full Name:
Signal transducer and activator of transcription 6
Alias:
IL-4 Stat
Type:
Transcription protein
Mass (Da):
94135
Number AA:
847
UniProt ID:
P42226
International Prot ID:
IPI00030782
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
L
W
G
L
V
S
K
M
P
P
E
K
V
Site 2
Y19
P
E
K
V
Q
R
L
Y
V
D
F
P
Q
H
L
Site 3
S67
T
V
Q
H
L
Q
A
S
V
G
E
Q
G
E
G
Site 4
S82
S
T
I
L
Q
H
I
S
T
L
E
S
I
Y
Q
Site 5
S86
Q
H
I
S
T
L
E
S
I
Y
Q
R
D
P
L
Site 6
Y88
I
S
T
L
E
S
I
Y
Q
R
D
P
L
K
L
Site 7
T132
Q
E
E
L
K
F
K
T
G
L
R
R
L
Q
H
Site 8
S164
A
G
Q
V
S
L
H
S
L
I
E
T
P
A
N
Site 9
T168
S
L
H
S
L
I
E
T
P
A
N
G
T
G
P
Site 10
S220
N
G
A
P
F
E
E
S
L
A
P
L
Q
E
R
Site 11
S230
P
L
Q
E
R
C
E
S
L
V
D
I
Y
S
Q
Site 12
Y235
C
E
S
L
V
D
I
Y
S
Q
L
Q
Q
E
V
Site 13
S236
E
S
L
V
D
I
Y
S
Q
L
Q
Q
E
V
G
Site 14
T253
G
G
E
L
E
P
K
T
R
A
S
L
T
G
R
Site 15
S256
L
E
P
K
T
R
A
S
L
T
G
R
L
D
E
Site 16
T285
Q
P
P
Q
V
L
K
T
Q
T
K
F
Q
A
G
Site 17
T317
L
V
R
A
D
M
V
T
E
K
Q
A
R
E
L
Site 18
S325
E
K
Q
A
R
E
L
S
V
P
Q
G
P
G
A
Site 19
T344
T
G
E
I
I
N
N
T
V
P
L
E
N
S
I
Site 20
T376
K
R
C
E
R
K
G
T
E
S
V
T
E
E
K
Site 21
S378
C
E
R
K
G
T
E
S
V
T
E
E
K
C
A
Site 22
S407
P
I
Q
L
Q
A
L
S
L
P
L
V
V
I
V
Site 23
T465
K
F
M
A
E
V
G
T
N
R
G
L
L
P
E
Site 24
S486
Q
K
I
F
N
D
N
S
L
S
M
E
A
F
Q
Site 25
S498
A
F
Q
H
R
S
V
S
W
S
Q
F
N
K
E
Site 26
S500
Q
H
R
S
V
S
W
S
Q
F
N
K
E
I
L
Site 27
T525
F
D
G
V
L
D
L
T
K
R
C
L
R
S
Y
Site 28
Y532
T
K
R
C
L
R
S
Y
W
S
D
R
L
I
I
Site 29
T558
L
L
N
E
P
D
G
T
F
L
L
R
F
S
D
Site 30
S583
V
I
R
G
Q
D
G
S
P
Q
I
E
N
I
Q
Site 31
S593
I
E
N
I
Q
P
F
S
A
K
D
L
S
I
R
Site 32
S598
P
F
S
A
K
D
L
S
I
R
S
L
G
D
R
Site 33
S601
A
K
D
L
S
I
R
S
L
G
D
R
I
R
D
Site 34
Y616
L
A
Q
L
K
N
L
Y
P
K
K
P
K
D
E
Site 35
S627
P
K
D
E
A
F
R
S
H
Y
K
P
E
Q
M
Site 36
Y629
D
E
A
F
R
S
H
Y
K
P
E
Q
M
G
K
Site 37
Y641
M
G
K
D
G
R
G
Y
V
P
A
T
I
K
M
Site 38
T645
G
R
G
Y
V
P
A
T
I
K
M
T
V
E
R
Site 39
T658
E
R
D
Q
P
L
P
T
P
E
L
Q
M
P
T
Site 40
T665
T
P
E
L
Q
M
P
T
M
V
P
S
Y
D
L
Site 41
Y670
M
P
T
M
V
P
S
Y
D
L
G
M
A
P
D
Site 42
S678
D
L
G
M
A
P
D
S
S
M
S
M
Q
L
G
Site 43
S679
L
G
M
A
P
D
S
S
M
S
M
Q
L
G
P
Site 44
S681
M
A
P
D
S
S
M
S
M
Q
L
G
P
D
M
Site 45
Y693
P
D
M
V
P
Q
V
Y
P
P
H
S
H
S
I
Site 46
S697
P
Q
V
Y
P
P
H
S
H
S
I
P
P
Y
Q
Site 47
S699
V
Y
P
P
H
S
H
S
I
P
P
Y
Q
G
L
Site 48
Y703
H
S
H
S
I
P
P
Y
Q
G
L
S
P
E
E
Site 49
S707
I
P
P
Y
Q
G
L
S
P
E
E
S
V
N
V
Site 50
S711
Q
G
L
S
P
E
E
S
V
N
V
L
S
A
F
Site 51
S716
E
E
S
V
N
V
L
S
A
F
Q
E
P
H
L
Site 52
S728
P
H
L
Q
M
P
P
S
L
G
Q
M
S
L
P
Site 53
S733
P
P
S
L
G
Q
M
S
L
P
F
D
Q
P
H
Site 54
S755
Q
P
Q
E
H
A
V
S
S
P
D
P
L
L
C
Site 55
S756
P
Q
E
H
A
V
S
S
P
D
P
L
L
C
S
Site 56
S763
S
P
D
P
L
L
C
S
D
V
T
M
V
E
D
Site 57
T778
S
C
L
S
Q
P
V
T
A
F
P
Q
G
T
W
Site 58
T798
F
P
P
L
L
P
P
T
E
Q
D
L
T
K
L
Site 59
T803
P
P
T
E
Q
D
L
T
K
L
L
L
E
G
Q
Site 60
S813
L
L
E
G
Q
G
E
S
G
G
G
S
L
G
A
Site 61
S817
Q
G
E
S
G
G
G
S
L
G
A
Q
P
L
L
Site 62
S827
A
Q
P
L
L
Q
P
S
H
Y
G
Q
S
G
I
Site 63
Y829
P
L
L
Q
P
S
H
Y
G
Q
S
G
I
S
M
Site 64
S832
Q
P
S
H
Y
G
Q
S
G
I
S
M
S
H
M
Site 65
S837
G
Q
S
G
I
S
M
S
H
M
D
L
R
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation