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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SmcX
Full Name:
Lysine-specific demethylase 5C
Alias:
DXS1272E; Histone demethylase JARID1C; JAD1C; JARID1C; JD1C; Jumonji/ARID domain-containing protein 1C; KDM5C; Lysine (K)-specific demethylase 5C; SMCX; Xe169
Type:
Oxidoreductase; Demethylase; EC 1.14.11.-
Mass (Da):
175720
Number AA:
1560
UniProt ID:
P41229
International Prot ID:
IPI00013185
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005506
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
C
P
V
F
E
P
S
W
A
E
F
R
D
P
Site 2
Y30
E
F
R
D
P
L
G
Y
I
A
K
I
R
P
I
Site 3
T66
E
V
D
N
F
R
F
T
P
R
I
Q
R
L
N
Site 4
Y85
Q
T
R
V
K
L
N
Y
L
D
Q
I
A
K
F
Site 5
S98
K
F
W
E
I
Q
G
S
S
L
K
I
P
N
V
Site 6
Y125
I
V
V
E
E
G
G
Y
E
A
I
C
K
D
R
Site 7
Y143
R
V
A
Q
R
L
N
Y
P
P
G
K
N
I
G
Site 8
S151
P
P
G
K
N
I
G
S
L
L
R
S
H
Y
E
Site 9
S155
N
I
G
S
L
L
R
S
H
Y
E
R
I
V
Y
Site 10
Y157
G
S
L
L
R
S
H
Y
E
R
I
V
Y
P
Y
Site 11
Y162
S
H
Y
E
R
I
V
Y
P
Y
E
M
Y
Q
S
Site 12
Y164
Y
E
R
I
V
Y
P
Y
E
M
Y
Q
S
G
A
Site 13
Y190
N
E
E
K
D
K
E
Y
K
P
H
S
I
P
L
Site 14
S194
D
K
E
Y
K
P
H
S
I
P
L
R
Q
S
V
Site 15
S200
H
S
I
P
L
R
Q
S
V
Q
P
S
K
F
N
Site 16
S204
L
R
Q
S
V
Q
P
S
K
F
N
S
Y
G
R
Site 17
S208
V
Q
P
S
K
F
N
S
Y
G
R
R
A
K
R
Site 18
Y209
Q
P
S
K
F
N
S
Y
G
R
R
A
K
R
L
Site 19
Y239
E
L
K
K
L
Q
I
Y
G
A
G
P
K
M
M
Site 20
T256
G
L
M
A
K
D
K
T
L
R
K
K
D
K
E
Site 21
T270
E
G
P
E
C
P
P
T
V
V
V
K
E
E
L
Site 22
S285
G
G
D
V
K
V
E
S
T
S
P
K
T
F
L
Site 23
S287
D
V
K
V
E
S
T
S
P
K
T
F
L
E
S
Site 24
T290
V
E
S
T
S
P
K
T
F
L
E
S
K
E
E
Site 25
S294
S
P
K
T
F
L
E
S
K
E
E
L
S
H
S
Site 26
S299
L
E
S
K
E
E
L
S
H
S
P
E
P
C
T
Site 27
S301
S
K
E
E
L
S
H
S
P
E
P
C
T
K
M
Site 28
S317
M
R
L
R
R
N
H
S
N
A
Q
F
I
E
S
Site 29
Y325
N
A
Q
F
I
E
S
Y
V
C
R
M
C
S
R
Site 30
S331
S
Y
V
C
R
M
C
S
R
G
D
E
D
D
K
Site 31
Y392
F
E
Q
A
T
R
E
Y
T
L
Q
S
F
G
E
Site 32
T393
E
Q
A
T
R
E
Y
T
L
Q
S
F
G
E
M
Site 33
S396
T
R
E
Y
T
L
Q
S
F
G
E
M
A
D
S
Site 34
S403
S
F
G
E
M
A
D
S
F
K
A
D
Y
F
N
Site 35
Y408
A
D
S
F
K
A
D
Y
F
N
M
P
V
H
M
Site 36
S431
E
F
W
R
L
V
N
S
I
E
E
D
V
T
V
Site 37
T437
N
S
I
E
E
D
V
T
V
E
Y
G
A
D
I
Site 38
Y440
E
E
D
V
T
V
E
Y
G
A
D
I
H
S
K
Site 39
S446
E
Y
G
A
D
I
H
S
K
E
F
G
S
G
F
Site 40
S456
F
G
S
G
F
P
V
S
D
S
K
R
H
L
T
Site 41
S458
S
G
F
P
V
S
D
S
K
R
H
L
T
P
E
Site 42
T463
S
D
S
K
R
H
L
T
P
E
E
E
E
Y
A
Site 43
Y469
L
T
P
E
E
E
E
Y
A
T
S
G
W
N
L
Site 44
T471
P
E
E
E
E
Y
A
T
S
G
W
N
L
N
V
Site 45
Y535
W
G
E
P
K
T
W
Y
G
V
P
S
L
A
A
Site 46
T553
E
E
V
M
K
K
L
T
P
E
L
F
D
S
Q
Site 47
S559
L
T
P
E
L
F
D
S
Q
P
D
L
L
H
Q
Site 48
S578
M
N
P
N
T
L
M
S
H
G
V
P
V
V
R
Site 49
Y601
V
I
T
F
P
R
A
Y
H
S
G
F
N
Q
G
Site 50
Y633
G
R
Q
C
I
E
H
Y
R
R
L
R
R
Y
C
Site 51
Y639
H
Y
R
R
L
R
R
Y
C
V
F
S
H
E
E
Site 52
T690
A
L
L
E
K
G
I
T
E
A
E
R
E
A
F
Site 53
S741
I
N
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Site 54
S742
N
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Y
Site 55
S743
D
L
C
K
C
S
S
S
R
Q
Y
L
R
Y
R
Site 56
Y746
K
C
S
S
S
R
Q
Y
L
R
Y
R
Y
T
L
Site 57
Y749
S
S
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
Site 58
Y751
R
Q
Y
L
R
Y
R
Y
T
L
D
E
L
P
A
Site 59
T752
Q
Y
L
R
Y
R
Y
T
L
D
E
L
P
A
M
Site 60
S769
K
L
K
V
R
A
E
S
F
D
T
W
A
N
K
Site 61
T772
V
R
A
E
S
F
D
T
W
A
N
K
V
R
V
Site 62
S790
V
E
D
G
R
K
R
S
L
E
E
L
R
A
L
Site 63
S799
E
E
L
R
A
L
E
S
E
A
R
E
R
R
F
Site 64
S809
R
E
R
R
F
P
N
S
E
L
L
Q
Q
L
K
Site 65
S820
Q
Q
L
K
N
C
L
S
E
A
E
A
C
V
S
Site 66
T849
R
V
A
G
L
Q
M
T
L
T
E
L
R
A
F
Site 67
S893
E
A
R
E
A
L
A
S
L
P
S
S
P
G
L
Site 68
S897
A
L
A
S
L
P
S
S
P
G
L
L
Q
S
L
Site 69
S903
S
S
P
G
L
L
Q
S
L
L
E
R
G
R
Q
Site 70
T937
W
L
D
E
V
K
R
T
L
A
P
S
A
R
R
Site 71
S941
V
K
R
T
L
A
P
S
A
R
R
G
T
L
A
Site 72
S963
A
G
A
S
V
A
P
S
P
A
V
D
K
A
Q
Site 73
T1001
R
Q
K
H
P
P
A
T
L
E
A
I
I
R
E
Site 74
Y1045
E
I
Q
N
G
D
H
Y
P
C
L
D
D
L
E
Site 75
S1080
L
Q
V
L
T
A
H
S
W
R
E
K
A
S
K
Site 76
T1088
W
R
E
K
A
S
K
T
F
L
K
K
N
S
C
Site 77
S1110
C
P
C
A
D
A
G
S
D
S
T
K
R
S
R
Site 78
S1112
C
A
D
A
G
S
D
S
T
K
R
S
R
W
M
Site 79
T1113
A
D
A
G
S
D
S
T
K
R
S
R
W
M
E
Site 80
S1116
G
S
D
S
T
K
R
S
R
W
M
E
K
E
L
Site 81
Y1126
M
E
K
E
L
G
L
Y
K
S
D
T
E
L
L
Site 82
S1128
K
E
L
G
L
Y
K
S
D
T
E
L
L
G
L
Site 83
S1145
Q
D
L
R
D
P
G
S
V
I
V
A
F
K
E
Site 84
T1167
G
I
L
Q
L
R
R
T
N
S
A
K
P
S
P
Site 85
S1169
L
Q
L
R
R
T
N
S
A
K
P
S
P
L
A
Site 86
S1173
R
T
N
S
A
K
P
S
P
L
A
S
S
S
T
Site 87
S1177
A
K
P
S
P
L
A
S
S
S
T
A
S
S
T
Site 88
S1178
K
P
S
P
L
A
S
S
S
T
A
S
S
T
T
Site 89
S1179
P
S
P
L
A
S
S
S
T
A
S
S
T
T
S
Site 90
T1180
S
P
L
A
S
S
S
T
A
S
S
T
T
S
I
Site 91
S1221
V
S
V
P
R
L
L
S
S
P
R
P
N
P
T
Site 92
S1222
S
V
P
R
L
L
S
S
P
R
P
N
P
T
S
Site 93
T1228
S
S
P
R
P
N
P
T
S
S
P
L
L
A
W
Site 94
S1229
S
P
R
P
N
P
T
S
S
P
L
L
A
W
W
Site 95
S1230
P
R
P
N
P
T
S
S
P
L
L
A
W
W
E
Site 96
S1250
L
C
P
L
C
M
R
S
R
R
P
R
L
E
T
Site 97
T1257
S
R
R
P
R
L
E
T
I
L
A
L
L
V
A
Site 98
T1282
G
E
A
L
Q
C
L
T
E
R
A
I
S
W
Q
Site 99
S1287
C
L
T
E
R
A
I
S
W
Q
G
R
A
R
Q
Site 100
Y1327
R
P
E
E
P
P
N
Y
P
A
A
P
A
S
D
Site 101
S1333
N
Y
P
A
A
P
A
S
D
P
L
R
E
G
S
Site 102
S1340
S
D
P
L
R
E
G
S
G
K
D
M
P
K
V
Site 103
S1356
G
L
L
E
N
G
D
S
V
T
S
P
E
K
V
Site 104
T1358
L
E
N
G
D
S
V
T
S
P
E
K
V
A
P
Site 105
S1359
E
N
G
D
S
V
T
S
P
E
K
V
A
P
E
Site 106
S1378
K
R
D
L
E
L
L
S
S
L
L
P
Q
L
T
Site 107
T1412
E
G
D
L
L
E
V
T
L
D
E
N
H
S
I
Site 108
S1418
V
T
L
D
E
N
H
S
I
W
Q
L
L
Q
A
Site 109
T1436
P
D
L
E
R
I
R
T
L
L
E
L
E
K
A
Site 110
S1448
E
K
A
E
R
H
G
S
R
A
R
G
R
A
L
Site 111
S1484
L
E
P
K
R
V
R
S
S
G
P
E
A
E
E
Site 112
S1485
E
P
K
R
V
R
S
S
G
P
E
A
E
E
V
Site 113
T1514
P
P
A
P
I
P
T
T
G
S
P
S
T
Q
E
Site 114
S1516
A
P
I
P
T
T
G
S
P
S
T
Q
E
N
Q
Site 115
S1534
E
P
A
E
G
T
T
S
G
P
S
A
P
F
S
Site 116
S1537
E
G
T
T
S
G
P
S
A
P
F
S
T
L
T
Site 117
S1541
S
G
P
S
A
P
F
S
T
L
T
P
R
L
H
Site 118
T1542
G
P
S
A
P
F
S
T
L
T
P
R
L
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation