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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBE1L
Full Name:
Ubiquitin-like modifier-activating enzyme 7
Alias:
D8; UBA1, ubiquitin-activating enzyme E1 B; UBA1B; UBA7; UBA7, ubiquitin-activating enzyme E1; UBE2; ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-like; ubiquitin-activating enzyme E1-related protein; ubiquitin-activating enzyme-2; ubiquitin-like modifier activating enzyme 7
Type:
Ubiquitin conjugating system
Mass (Da):
111720
Number AA:
1011
UniProt ID:
P41226
International Prot ID:
IPI00013183
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0019782
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0032020
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
K
L
L
D
E
E
L
Y
S
R
Q
L
Y
V
L
Site 2
Y20
E
L
Y
S
R
Q
L
Y
V
L
G
S
P
A
M
Site 3
S24
R
Q
L
Y
V
L
G
S
P
A
M
Q
R
I
Q
Site 4
S79
L
A
A
Q
F
L
L
S
E
Q
D
L
E
R
S
Site 5
S91
E
R
S
R
A
E
A
S
Q
E
L
L
A
Q
L
Site 6
T167
C
D
F
G
E
D
F
T
V
Q
D
P
T
E
A
Site 7
T178
P
T
E
A
E
P
L
T
A
A
I
Q
H
I
S
Site 8
S188
I
Q
H
I
S
Q
G
S
P
G
I
L
T
L
R
Site 9
T193
Q
G
S
P
G
I
L
T
L
R
K
G
A
N
T
Site 10
T200
T
L
R
K
G
A
N
T
H
Y
F
R
D
G
D
Site 11
Y202
R
K
G
A
N
T
H
Y
F
R
D
G
D
L
V
Site 12
S227
L
N
D
C
D
P
R
S
I
H
V
R
E
D
G
Site 13
T241
G
S
L
E
I
G
D
T
T
T
F
S
R
Y
L
Site 14
T242
S
L
E
I
G
D
T
T
T
F
S
R
Y
L
R
Site 15
T243
L
E
I
G
D
T
T
T
F
S
R
Y
L
R
G
Site 16
S245
I
G
D
T
T
T
F
S
R
Y
L
R
G
G
A
Site 17
Y247
D
T
T
T
F
S
R
Y
L
R
G
G
A
I
T
Site 18
T254
Y
L
R
G
G
A
I
T
E
V
K
R
P
K
T
Site 19
T261
T
E
V
K
R
P
K
T
V
R
H
K
S
L
D
Site 20
S266
P
K
T
V
R
H
K
S
L
D
T
A
L
L
Q
Site 21
T269
V
R
H
K
S
L
D
T
A
L
L
Q
P
H
V
Site 22
S281
P
H
V
V
A
Q
S
S
Q
E
V
H
H
A
H
Site 23
T318
W
D
P
V
D
A
E
T
V
V
G
L
A
R
D
Site 24
S404
E
D
G
E
L
L
P
S
P
E
D
C
A
L
R
Site 25
S413
E
D
C
A
L
R
G
S
R
Y
D
G
Q
I
A
Site 26
Y435
E
K
L
R
R
Q
H
Y
L
L
V
G
A
G
A
Site 27
S478
H
I
E
R
S
N
L
S
R
Q
F
L
F
R
S
Site 28
S485
S
R
Q
F
L
F
R
S
Q
D
V
G
R
P
K
Site 29
Y514
L
Q
V
I
P
L
T
Y
P
L
D
P
T
T
E
Site 30
T519
L
T
Y
P
L
D
P
T
T
E
H
I
Y
G
D
Site 31
T520
T
Y
P
L
D
P
T
T
E
H
I
Y
G
D
N
Site 32
Y524
D
P
T
T
E
H
I
Y
G
D
N
F
F
S
R
Site 33
Y547
D
S
F
Q
A
R
R
Y
V
A
A
R
C
T
H
Site 34
Y555
V
A
A
R
C
T
H
Y
L
K
P
L
L
E
A
Site 35
S565
P
L
L
E
A
G
T
S
G
T
W
G
S
A
T
Site 36
S570
G
T
S
G
T
W
G
S
A
T
V
F
M
P
H
Site 37
Y582
M
P
H
V
T
E
A
Y
R
A
P
A
S
A
A
Site 38
S587
E
A
Y
R
A
P
A
S
A
A
A
S
E
D
A
Site 39
S591
A
P
A
S
A
A
A
S
E
D
A
P
Y
P
V
Site 40
Y596
A
A
S
E
D
A
P
Y
P
V
C
T
V
R
Y
Site 41
T600
D
A
P
Y
P
V
C
T
V
R
Y
F
P
S
T
Site 42
Y603
Y
P
V
C
T
V
R
Y
F
P
S
T
A
E
H
Site 43
T607
T
V
R
Y
F
P
S
T
A
E
H
T
L
Q
W
Site 44
S626
F
E
E
L
F
R
L
S
A
E
T
I
N
H
H
Site 45
S639
H
H
Q
Q
A
H
T
S
L
A
D
M
D
E
P
Site 46
T702
N
K
V
L
E
D
G
T
P
F
W
S
G
P
K
Site 47
T719
P
Q
P
L
E
F
D
T
N
Q
D
T
H
L
L
Site 48
S744
Q
M
H
G
L
P
G
S
Q
D
W
T
A
L
R
Site 49
T748
L
P
G
S
Q
D
W
T
A
L
R
E
L
L
K
Site 50
S779
N
L
E
L
A
S
A
S
A
E
F
G
P
E
Q
Site 51
S798
N
K
A
L
E
V
W
S
V
G
P
P
L
K
P
Site 52
Y832
A
S
L
R
C
Q
N
Y
G
I
P
P
V
N
R
Site 53
S842
P
P
V
N
R
A
Q
S
K
R
I
V
G
Q
I
Site 54
S873
L
E
L
Y
K
V
V
S
G
P
R
P
R
S
A
Site 55
S879
V
S
G
P
R
P
R
S
A
F
R
H
S
Y
L
Site 56
S884
P
R
S
A
F
R
H
S
Y
L
H
L
A
E
N
Site 57
Y885
R
S
A
F
R
H
S
Y
L
H
L
A
E
N
Y
Site 58
Y892
Y
L
H
L
A
E
N
Y
L
I
R
Y
M
P
F
Site 59
Y896
A
E
N
Y
L
I
R
Y
M
P
F
A
P
A
I
Site 60
T927
P
A
G
Q
P
E
R
T
L
E
S
L
L
A
H
Site 61
S959
L
L
Y
A
A
G
W
S
P
E
K
Q
A
Q
H
Site 62
T972
Q
H
L
P
L
R
V
T
E
L
V
Q
Q
L
T
Site 63
S995
R
V
L
V
L
E
L
S
C
E
G
D
D
E
D
Site 64
T1003
C
E
G
D
D
E
D
T
A
F
P
P
L
H
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation