PhosphoNET

           
Protein Info 
   
Short Name:  PTGDS
Full Name:  Prostaglandin-H2 D-isomerase
Alias:  Beta-trace; Cerebrin-28; Glutathione-independent PGD synthetase; Lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; L-PGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; Prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase
Type:  EC 5.3.99.2; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum; Transporter; Isomerase
Mass (Da):  21029
Number AA:  190
UniProt ID:  P41222
International Prot ID:  IPI00013179
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005794  GO:0005576  GO:0031965 Uniprot OncoNet
Molecular Function:  GO:0004667  GO:0005501  GO:0005215 PhosphoSite+ KinaseNET
Biological Process:  GO:0001516  GO:0045187  GO:0006810 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S29AAPEAQVSVQPNFQQ
Site 2S45KFLGRWFSAGLASNS
Site 3S50WFSAGLASNSSWLRE
Site 4S52SAGLASNSSWLREKK
Site 5S53AGLASNSSWLREKKA
Site 6S63REKKAALSMCKSVVA
Site 7T82GGLNLTSTFLRKNQC
Site 8S101MLLQPAGSLGSYSYR
Site 9S104QPAGSLGSYSYRSPH
Site 10Y105PAGSLGSYSYRSPHW
Site 11S106AGSLGSYSYRSPHWG
Site 12Y107GSLGSYSYRSPHWGS
Site 13S109LGSYSYRSPHWGSTY
Site 14S114YRSPHWGSTYSVSVV
Site 15T115RSPHWGSTYSVSVVE
Site 16Y116SPHWGSTYSVSVVET
Site 17S117PHWGSTYSVSVVETD
Site 18S119WGSTYSVSVVETDYD
Site 19T123YSVSVVETDYDQYAL
Site 20Y128VETDYDQYALLYSQG
Site 21Y132YDQYALLYSQGSKGP
Site 22S133DQYALLYSQGSKGPG
Site 23S136ALLYSQGSKGPGEDF
Site 24T147GEDFRMATLYSRTQT
Site 25Y149DFRMATLYSRTQTPR
Site 26T154TLYSRTQTPRAELKE
Site 27T183TIVFLPQTDKCMTEQ
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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