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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HADHA
Full Name:
Trifunctional enzyme subunit alpha, mitochondrial
Alias:
78 kDa gastrin-binding protein; ECHA; GBP; HADH; Hydroxyacyl dehydrogenase, subunit A; Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein) alpha subunit; Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; LCHAD; Long chain 3-hydroxyacyl-CoA dehydrogenase; Long-chain hydroxyacyl-CoA dehydrogenase; Mitochondrial trifunctional protein, alpha subunit; MTPA; TP-alpha; Trifunctional enzyme alpha subunit, mitochondrial; Trifunctional protein, alpha subunit
Type:
Mitochondrial; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - unsaturated fatty acid biosynthesis; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid elongation in mitochondria; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tryptophan; Other Amino Acids Metabolism - beta-alanine; Lyase; Oxidoreductase; EC 4.2.1.17; Acetyltransferase; EC 1.1.1.211
Mass (Da):
83000
Number AA:
763
UniProt ID:
P40939
International Prot ID:
IPI00031522
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016507
GO:0042645
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0003857
GO:0003985
GO:0004300
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006629
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
R
I
L
R
S
R
G
Y
I
C
R
N
F
T
G
Site 2
T37
T
G
S
S
A
L
L
T
R
T
H
I
N
Y
G
Site 3
Y43
L
T
R
T
H
I
N
Y
G
V
K
G
D
V
A
Site 4
S56
V
A
V
V
R
I
N
S
P
N
S
K
V
N
T
Site 5
S59
V
R
I
N
S
P
N
S
K
V
N
T
L
S
K
Site 6
T63
S
P
N
S
K
V
N
T
L
S
K
E
L
H
S
Site 7
S65
N
S
K
V
N
T
L
S
K
E
L
H
S
E
F
Site 8
S120
L
Q
E
V
T
Q
L
S
Q
E
A
Q
R
I
V
Site 9
T162
S
C
Q
Y
R
I
A
T
K
D
R
K
T
V
L
Site 10
T167
I
A
T
K
D
R
K
T
V
L
G
T
P
E
V
Site 11
T171
D
R
K
T
V
L
G
T
P
E
V
L
L
G
A
Site 12
T203
A
A
L
D
M
M
L
T
G
R
S
I
R
A
D
Site 13
S206
D
M
M
L
T
G
R
S
I
R
A
D
R
A
K
Site 14
Y239
P
E
E
R
T
I
E
Y
L
E
E
V
A
I
T
Site 15
S257
G
L
A
D
K
K
I
S
P
K
R
D
K
G
L
Site 16
Y283
P
F
V
R
Q
Q
V
Y
K
K
V
E
E
K
V
Site 17
T294
E
E
K
V
R
K
Q
T
K
G
L
Y
P
A
P
Site 18
Y298
R
K
Q
T
K
G
L
Y
P
A
P
L
K
I
I
Site 19
T310
K
I
I
D
V
V
K
T
G
I
E
Q
G
S
D
Site 20
S316
K
T
G
I
E
Q
G
S
D
A
G
Y
L
C
E
Site 21
Y320
E
Q
G
S
D
A
G
Y
L
C
E
S
Q
K
F
Site 22
S324
D
A
G
Y
L
C
E
S
Q
K
F
G
E
L
V
Site 23
T333
K
F
G
E
L
V
M
T
K
E
S
K
A
L
M
Site 24
T387
S
V
D
K
G
L
K
T
I
L
K
D
A
T
L
Site 25
T393
K
T
I
L
K
D
A
T
L
T
A
L
D
R
G
Site 26
T395
I
L
K
D
A
T
L
T
A
L
D
R
G
Q
Q
Site 27
S419
V
K
K
K
A
L
T
S
F
E
R
D
S
I
F
Site 28
S424
L
T
S
F
E
R
D
S
I
F
S
N
L
T
G
Site 29
S427
F
E
R
D
S
I
F
S
N
L
T
G
Q
L
D
Site 30
Y435
N
L
T
G
Q
L
D
Y
Q
G
F
E
K
A
D
Site 31
S453
E
A
V
F
E
D
L
S
L
K
H
R
V
L
K
Site 32
Y499
E
K
V
I
G
M
H
Y
F
S
P
V
D
K
M
Site 33
S501
V
I
G
M
H
Y
F
S
P
V
D
K
M
Q
L
Site 34
T514
Q
L
L
E
I
I
T
T
E
K
T
S
K
D
T
Site 35
T517
E
I
I
T
T
E
K
T
S
K
D
T
S
A
S
Site 36
S522
E
K
T
S
K
D
T
S
A
S
A
V
A
V
G
Site 37
Y546
V
K
D
G
P
G
F
Y
T
T
R
C
L
A
P
Site 38
T547
K
D
G
P
G
F
Y
T
T
R
C
L
A
P
M
Site 39
S573
V
D
P
K
K
L
D
S
L
T
T
S
F
G
F
Site 40
T575
P
K
K
L
D
S
L
T
T
S
F
G
F
P
V
Site 41
T576
K
K
L
D
S
L
T
T
S
F
G
F
P
V
G
Site 42
T620
G
G
N
P
E
L
L
T
Q
M
V
S
K
G
F
Site 43
S624
E
L
L
T
Q
M
V
S
K
G
F
L
G
R
K
Site 44
S632
K
G
F
L
G
R
K
S
G
K
G
F
Y
I
Y
Site 45
Y637
R
K
S
G
K
G
F
Y
I
Y
Q
E
G
V
K
Site 46
Y639
S
G
K
G
F
Y
I
Y
Q
E
G
V
K
R
K
Site 47
S650
V
K
R
K
D
L
N
S
D
M
D
S
I
L
A
Site 48
S658
D
M
D
S
I
L
A
S
L
K
L
P
P
K
S
Site 49
S665
S
L
K
L
P
P
K
S
E
V
S
S
D
E
D
Site 50
S669
P
P
K
S
E
V
S
S
D
E
D
I
Q
F
R
Site 51
Y724
P
F
R
F
V
D
L
Y
G
A
Q
K
I
V
D
Site 52
Y736
I
V
D
R
L
K
K
Y
E
A
A
Y
G
K
Q
Site 53
T745
A
A
Y
G
K
Q
F
T
P
C
Q
L
L
A
D
Site 54
S756
L
L
A
D
H
A
N
S
P
N
K
K
F
Y
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation