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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAP2
Full Name:
Adenylyl cyclase-associated protein 2
Alias:
Adenylyl cyclase-associated 2; CAP 2; CAP, adenylate cyclase-associated protein, 2
Type:
Cytoskeletal, actin binding protein; Plasma membrane protein
Mass (Da):
52824
Number AA:
477
UniProt ID:
P40123
International Prot ID:
IPI00027342
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0007190
GO:0007010
GO:0007163
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
R
L
E
R
A
V
S
R
L
E
S
L
S
A
Site 2
S20
R
A
V
S
R
L
E
S
L
S
A
E
S
H
R
Site 3
S22
V
S
R
L
E
S
L
S
A
E
S
H
R
P
P
Site 4
S25
L
E
S
L
S
A
E
S
H
R
P
P
G
N
C
Site 5
S80
T
H
A
E
M
V
H
S
A
F
Q
A
Q
R
A
Site 6
S93
R
A
F
L
L
M
A
S
Q
Y
Q
Q
P
H
E
Site 7
Y95
F
L
L
M
A
S
Q
Y
Q
Q
P
H
E
N
D
Site 8
S111
A
A
L
L
K
P
I
S
E
K
I
Q
E
I
Q
Site 9
T119
E
K
I
Q
E
I
Q
T
F
R
E
R
N
R
G
Site 10
S127
F
R
E
R
N
R
G
S
N
M
F
N
H
L
S
Site 11
S134
S
N
M
F
N
H
L
S
A
V
S
E
S
I
P
Site 12
Y155
V
S
P
K
P
G
P
Y
V
K
E
M
N
D
A
Site 13
T164
K
E
M
N
D
A
A
T
F
Y
T
N
R
V
L
Site 14
Y166
M
N
D
A
A
T
F
Y
T
N
R
V
L
K
D
Site 15
T167
N
D
A
A
T
F
Y
T
N
R
V
L
K
D
Y
Site 16
Y174
T
N
R
V
L
K
D
Y
K
H
S
D
L
R
H
Site 17
Y188
H
V
D
W
V
K
S
Y
L
N
I
W
S
E
L
Site 18
Y198
I
W
S
E
L
Q
A
Y
I
K
E
H
H
T
T
Site 19
T205
Y
I
K
E
H
H
T
T
G
L
T
W
S
K
T
Site 20
T208
E
H
H
T
T
G
L
T
W
S
K
T
G
P
V
Site 21
S210
H
T
T
G
L
T
W
S
K
T
G
P
V
A
S
Site 22
S256
N
E
G
K
K
E
E
S
S
P
S
R
S
A
L
Site 23
S257
E
G
K
K
E
E
S
S
P
S
R
S
A
L
F
Site 24
S259
K
K
E
E
S
S
P
S
R
S
A
L
F
A
Q
Site 25
S261
E
E
S
S
P
S
R
S
A
L
F
A
Q
L
N
Site 26
T281
T
K
G
L
R
H
V
T
D
D
Q
K
T
Y
K
Site 27
T286
H
V
T
D
D
Q
K
T
Y
K
N
P
S
L
R
Site 28
Y287
V
T
D
D
Q
K
T
Y
K
N
P
S
L
R
A
Site 29
S291
Q
K
T
Y
K
N
P
S
L
R
A
Q
G
G
Q
Site 30
T299
L
R
A
Q
G
G
Q
T
Q
S
P
T
K
S
H
Site 31
S301
A
Q
G
G
Q
T
Q
S
P
T
K
S
H
T
P
Site 32
T303
G
G
Q
T
Q
S
P
T
K
S
H
T
P
S
P
Site 33
S305
Q
T
Q
S
P
T
K
S
H
T
P
S
P
T
S
Site 34
T307
Q
S
P
T
K
S
H
T
P
S
P
T
S
P
K
Site 35
S309
P
T
K
S
H
T
P
S
P
T
S
P
K
S
Y
Site 36
T311
K
S
H
T
P
S
P
T
S
P
K
S
Y
P
S
Site 37
S312
S
H
T
P
S
P
T
S
P
K
S
Y
P
S
Q
Site 38
S315
P
S
P
T
S
P
K
S
Y
P
S
Q
K
H
A
Site 39
Y316
S
P
T
S
P
K
S
Y
P
S
Q
K
H
A
P
Site 40
S318
T
S
P
K
S
Y
P
S
Q
K
H
A
P
V
L
Site 41
Y336
G
K
K
W
R
V
E
Y
Q
E
D
R
N
D
L
Site 42
Y355
T
E
L
K
Q
V
A
Y
I
F
K
C
E
K
S
Site 43
T410
Q
V
M
G
R
V
P
T
I
S
I
N
K
T
E
Site 44
S412
M
G
R
V
P
T
I
S
I
N
K
T
E
G
C
Site 45
Y422
K
T
E
G
C
H
I
Y
L
S
E
D
A
L
D
Site 46
S424
E
G
C
H
I
Y
L
S
E
D
A
L
D
C
E
Site 47
S434
A
L
D
C
E
I
V
S
A
K
S
S
E
M
N
Site 48
Y450
L
I
P
Q
D
G
D
Y
R
E
F
P
I
P
E
Site 49
T461
P
I
P
E
Q
F
K
T
A
W
D
G
S
K
L
Site 50
T470
W
D
G
S
K
L
I
T
E
P
A
E
I
M
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation