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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4A3
Full Name:
Eukaryotic initiation factor 4A-III
Alias:
ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; EIF4AIII; Eukaryotic initiation factor 4A-like NUK-34; Eukaryotic translation initiation factor 4A isoform 3; Eukaryotic translation initiation factor 4A, isoform 3; HNMP265; IF4A3; KIAA0111; MGC10862; Nuclear matrix protein 265; NUK-34
Type:
Helicase; EC 3.6.1.-; RNA binding protein
Mass (Da):
46871
Number AA:
411
UniProt ID:
P38919
International Prot ID:
IPI00009328
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016607
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0008143
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0051028
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
T
T
A
T
M
A
T
S
G
Site 2
T6
_
_
M
A
T
T
A
T
M
A
T
S
G
S
A
Site 3
T9
A
T
T
A
T
M
A
T
S
G
S
A
R
K
R
Site 4
S10
T
T
A
T
M
A
T
S
G
S
A
R
K
R
L
Site 5
S12
A
T
M
A
T
S
G
S
A
R
K
R
L
L
K
Site 6
T24
L
L
K
E
E
D
M
T
K
V
E
F
E
T
S
Site 7
S31
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
Site 8
T37
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
Site 9
T39
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
Site 10
Y54
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Site 11
Y56
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Site 12
S82
G
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
Site 13
T86
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
Site 14
T89
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
Site 15
Y155
E
D
I
R
K
L
D
Y
G
Q
H
V
V
A
G
Site 16
T163
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
Site 17
S175
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
Site 18
T178
I
R
R
R
S
L
R
T
R
A
I
K
M
L
V
Site 19
Y202
K
G
F
K
E
Q
I
Y
D
V
Y
R
Y
L
P
Site 20
Y205
K
E
Q
I
Y
D
V
Y
R
Y
L
P
P
A
T
Site 21
Y207
Q
I
Y
D
V
Y
R
Y
L
P
P
A
T
Q
V
Site 22
T247
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
Site 23
T267
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
Site 24
T294
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
Site 25
T303
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
Site 26
S318
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
Site 27
Y352
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
Site 28
Y361
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
Site 29
S368
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
Site 30
Y371
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
Site 31
Y395
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation