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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIPA
Full Name:
Lysosomal acid lipase/cholesteryl ester hydrolase
Alias:
Acid cholesteryl ester hydrolase; CESD; Cholesterol ester hydrolase; Cholesteryl esterase; EC 3.1.1.13; LAL; LICH; Lipase A; Lipase A, lysosomal acid, cholesterol esterase (Wolman disease); Lysosomal acid lipase; Lysosomal acid lipase/cholesteryl ester hydrolase precursor; Sterol esterase
Type:
Enzyme - Hydrolase
Mass (Da):
45419
Number AA:
399
UniProt ID:
P38571
International Prot ID:
Isoform1 - IPI00007207
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004771
PhosphoSite+
KinaseNET
Biological Process:
GO:0016042
GO:0006487
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
L
T
A
V
D
P
E
T
N
M
N
V
S
E
I
Site 2
Y43
N
V
S
E
I
I
S
Y
W
G
F
P
S
E
E
Site 3
Y51
W
G
F
P
S
E
E
Y
L
V
E
T
E
D
G
Site 4
S92
Q
H
G
L
L
A
D
S
S
N
W
V
T
N
L
Site 5
S93
H
G
L
L
A
D
S
S
N
W
V
T
N
L
A
Site 6
T97
A
D
S
S
N
W
V
T
N
L
A
N
S
S
L
Site 7
T124
M
G
N
S
R
G
N
T
W
S
R
K
H
K
T
Site 8
S126
N
S
R
G
N
T
W
S
R
K
H
K
T
L
S
Site 9
T131
T
W
S
R
K
H
K
T
L
S
V
S
Q
D
E
Site 10
S133
S
R
K
H
K
T
L
S
V
S
Q
D
E
F
W
Site 11
S135
K
H
K
T
L
S
V
S
Q
D
E
F
W
A
F
Site 12
Y144
D
E
F
W
A
F
S
Y
D
E
M
A
K
Y
D
Site 13
Y150
S
Y
D
E
M
A
K
Y
D
L
P
A
S
I
N
Site 14
S155
A
K
Y
D
L
P
A
S
I
N
F
I
L
N
K
Site 15
Y169
K
T
G
Q
E
Q
V
Y
Y
V
G
H
S
Q
G
Site 16
Y170
T
G
Q
E
Q
V
Y
Y
V
G
H
S
Q
G
T
Site 17
S237
D
K
E
F
L
P
Q
S
A
F
L
K
W
L
G
Site 18
S275
N
E
R
N
L
N
M
S
R
V
D
V
Y
T
T
Site 19
Y280
N
M
S
R
V
D
V
Y
T
T
H
S
P
A
G
Site 20
T281
M
S
R
V
D
V
Y
T
T
H
S
P
A
G
T
Site 21
T282
S
R
V
D
V
Y
T
T
H
S
P
A
G
T
S
Site 22
S284
V
D
V
Y
T
T
H
S
P
A
G
T
S
V
Q
Site 23
Y317
W
G
S
S
A
K
N
Y
F
H
Y
N
Q
S
Y
Site 24
Y320
S
A
K
N
Y
F
H
Y
N
Q
S
Y
P
P
T
Site 25
Y324
Y
F
H
Y
N
Q
S
Y
P
P
T
Y
N
V
K
Site 26
Y328
N
Q
S
Y
P
P
T
Y
N
V
K
D
M
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation