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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GGCX
Full Name:
Vitamin K-dependent gamma-carboxylase
Alias:
EC 6.4.-.-; Gamma-glutamyl carboxylase; VKCFD1; VKGC
Type:
Enzyme, carboxylase
Mass (Da):
87561
Number AA:
758
UniProt ID:
P38435
International Prot ID:
IPI00305698
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0008488
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0017187
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
V
S
A
G
S
A
R
T
S
P
S
S
Site 2
T10
V
S
A
G
S
A
R
T
S
P
S
S
D
K
V
Site 3
S11
S
A
G
S
A
R
T
S
P
S
S
D
K
V
Q
Site 4
S13
G
S
A
R
T
S
P
S
S
D
K
V
Q
K
D
Site 5
S14
S
A
R
T
S
P
S
S
D
K
V
Q
K
D
K
Site 6
S32
I
S
G
P
R
Q
D
S
R
I
G
K
L
L
G
Site 7
T43
K
L
L
G
F
E
W
T
D
L
S
S
W
R
R
Site 8
S46
G
F
E
W
T
D
L
S
S
W
R
R
L
V
T
Site 9
S47
F
E
W
T
D
L
S
S
W
R
R
L
V
T
L
Site 10
T53
S
S
W
R
R
L
V
T
L
L
N
R
P
T
D
Site 11
S63
N
R
P
T
D
P
A
S
L
A
V
F
R
F
L
Site 12
S86
I
P
Q
E
R
G
L
S
S
L
D
R
K
Y
L
Site 13
S87
P
Q
E
R
G
L
S
S
L
D
R
K
Y
L
D
Site 14
Y92
L
S
S
L
D
R
K
Y
L
D
G
L
D
V
C
Site 15
Y135
G
M
M
L
G
L
C
Y
R
I
S
C
V
L
F
Site 16
Y162
T
S
W
N
N
H
S
Y
L
Y
G
L
L
A
F
Site 17
Y179
T
F
M
D
A
N
H
Y
W
S
V
D
G
L
L
Site 18
Y231
V
E
G
Y
S
M
E
Y
L
S
R
H
W
L
F
Site 19
S312
A
S
S
P
L
F
C
S
P
E
W
P
R
K
L
Site 20
S321
E
W
P
R
K
L
V
S
Y
C
P
R
R
L
Q
Site 21
Y322
W
P
R
K
L
V
S
Y
C
P
R
R
L
Q
Q
Site 22
S342
A
A
P
Q
P
S
V
S
C
V
Y
K
R
S
R
Site 23
Y345
Q
P
S
V
S
C
V
Y
K
R
S
R
G
K
S
Site 24
S348
V
S
C
V
Y
K
R
S
R
G
K
S
G
Q
K
Site 25
S352
Y
K
R
S
R
G
K
S
G
Q
K
P
G
L
R
Site 26
S380
E
Q
L
F
L
P
Y
S
H
F
L
T
Q
G
Y
Site 27
Y387
S
H
F
L
T
Q
G
Y
N
N
W
T
N
G
L
Site 28
T414
S
H
Q
H
V
K
I
T
Y
R
D
G
R
T
G
Site 29
Y425
G
R
T
G
E
L
G
Y
L
N
P
G
V
F
T
Site 30
Y447
H
A
D
M
L
K
Q
Y
A
T
C
L
S
R
L
Site 31
S452
K
Q
Y
A
T
C
L
S
R
L
L
P
K
Y
N
Site 32
Y458
L
S
R
L
L
P
K
Y
N
V
T
E
P
Q
I
Site 33
Y466
N
V
T
E
P
Q
I
Y
F
D
I
W
V
S
I
Site 34
S472
I
Y
F
D
I
W
V
S
I
N
D
R
F
Q
Q
Site 35
S510
Q
P
L
L
M
D
L
S
P
W
R
A
K
L
Q
Site 36
S521
A
K
L
Q
E
I
K
S
S
L
D
N
H
T
E
Site 37
S522
K
L
Q
E
I
K
S
S
L
D
N
H
T
E
V
Site 38
T527
K
S
S
L
D
N
H
T
E
V
V
F
I
A
D
Site 39
S545
L
H
L
E
N
F
V
S
E
D
L
G
N
T
S
Site 40
T572
V
A
E
Q
K
N
Q
T
L
R
E
G
E
K
M
Site 41
Y590
A
G
E
Y
H
K
V
Y
T
T
S
P
S
P
S
Site 42
T591
G
E
Y
H
K
V
Y
T
T
S
P
S
P
S
C
Site 43
T592
E
Y
H
K
V
Y
T
T
S
P
S
P
S
C
Y
Site 44
S595
K
V
Y
T
T
S
P
S
P
S
C
Y
M
Y
V
Site 45
Y599
T
S
P
S
P
S
C
Y
M
Y
V
Y
V
N
T
Site 46
Y601
P
S
P
S
C
Y
M
Y
V
Y
V
N
T
T
E
Site 47
Y617
A
L
E
Q
D
L
A
Y
L
Q
E
L
K
E
K
Site 48
T658
E
P
T
P
L
V
Q
T
F
L
R
R
Q
Q
R
Site 49
T675
E
I
E
R
R
R
N
T
P
F
H
E
R
F
F
Site 50
S695
K
L
Y
V
F
R
R
S
F
L
M
T
C
I
S
Site 51
S712
N
L
I
L
G
R
P
S
L
E
Q
L
A
Q
E
Site 52
S737
A
V
G
E
L
N
P
S
N
T
D
S
S
H
S
Site 53
T739
G
E
L
N
P
S
N
T
D
S
S
H
S
N
P
Site 54
S741
L
N
P
S
N
T
D
S
S
H
S
N
P
P
E
Site 55
S742
N
P
S
N
T
D
S
S
H
S
N
P
P
E
S
Site 56
S744
S
N
T
D
S
S
H
S
N
P
P
E
S
N
P
Site 57
S749
S
H
S
N
P
P
E
S
N
P
D
P
V
H
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation