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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZEB1
Full Name:
Zinc finger E-box-binding homeobox 1
Alias:
AREB6; BZP; Negative regulator of IL2; NIL-2-A; NIL-2-A zinc finger protein; TCF-8; Transcription factor 8; ZEB; Zfhep; Zfhx1a; Zinc finger E-box binding homeobox 1
Type:
Transcription, coactivator/corepressor
Mass (Da):
124074
Number AA:
1124
UniProt ID:
P37275
International Prot ID:
IPI00375505
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003713
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0006955
GO:0000122
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
N
P
R
R
N
N
V
T
N
Y
N
T
V
V
E
Site 2
Y23
R
R
N
N
V
T
N
Y
N
T
V
V
E
T
N
Site 3
S31
N
T
V
V
E
T
N
S
D
S
D
D
E
D
K
Site 4
S33
V
V
E
T
N
S
D
S
D
D
E
D
K
L
H
Site 5
T48
I
V
E
E
E
S
V
T
D
A
A
D
C
E
G
Site 6
T63
V
P
E
D
D
L
P
T
D
Q
T
V
L
P
G
Site 7
T66
D
D
L
P
T
D
Q
T
V
L
P
G
R
S
S
Site 8
S73
T
V
L
P
G
R
S
S
E
R
E
G
N
A
K
Site 9
T106
Q
A
D
E
A
G
C
T
V
K
D
D
E
C
E
Site 10
T135
E
F
L
Q
Q
Q
D
T
A
V
I
F
P
E
A
Site 11
T151
E
E
D
Q
R
Q
G
T
P
E
A
S
G
H
D
Site 12
S155
R
Q
G
T
P
E
A
S
G
H
D
E
N
G
T
Site 13
T162
S
G
H
D
E
N
G
T
P
D
A
F
S
Q
L
Site 14
S167
N
G
T
P
D
A
F
S
Q
L
L
T
C
P
Y
Site 15
T171
D
A
F
S
Q
L
L
T
C
P
Y
C
D
R
G
Site 16
Y174
S
Q
L
L
T
C
P
Y
C
D
R
G
Y
K
R
Site 17
Y179
C
P
Y
C
D
R
G
Y
K
R
F
T
S
L
K
Site 18
T183
D
R
G
Y
K
R
F
T
S
L
K
E
H
I
K
Site 19
S184
R
G
Y
K
R
F
T
S
L
K
E
H
I
K
Y
Site 20
Y191
S
L
K
E
H
I
K
Y
R
H
E
K
N
E
D
Site 21
S201
E
K
N
E
D
N
F
S
C
S
L
C
S
Y
T
Site 22
Y207
F
S
C
S
L
C
S
Y
T
F
A
Y
R
T
Q
Site 23
T208
S
C
S
L
C
S
Y
T
F
A
Y
R
T
Q
L
Site 24
T220
T
Q
L
E
R
H
M
T
S
H
K
S
G
R
D
Site 25
S224
R
H
M
T
S
H
K
S
G
R
D
Q
R
H
V
Site 26
T232
G
R
D
Q
R
H
V
T
Q
S
G
C
N
R
K
Site 27
T243
C
N
R
K
F
K
C
T
E
C
G
K
A
F
K
Site 28
Y251
E
C
G
K
A
F
K
Y
K
H
H
L
K
E
H
Site 29
S263
K
E
H
L
R
I
H
S
G
E
K
P
Y
E
C
Site 30
Y268
I
H
S
G
E
K
P
Y
E
C
P
N
C
K
K
Site 31
S278
P
N
C
K
K
R
F
S
H
S
G
S
Y
S
S
Site 32
S280
C
K
K
R
F
S
H
S
G
S
Y
S
S
H
I
Site 33
S282
K
R
F
S
H
S
G
S
Y
S
S
H
I
S
S
Site 34
Y283
R
F
S
H
S
G
S
Y
S
S
H
I
S
S
K
Site 35
S284
F
S
H
S
G
S
Y
S
S
H
I
S
S
K
K
Site 36
S285
S
H
S
G
S
Y
S
S
H
I
S
S
K
K
C
Site 37
S288
G
S
Y
S
S
H
I
S
S
K
K
C
I
S
L
Site 38
S289
S
Y
S
S
H
I
S
S
K
K
C
I
S
L
I
Site 39
T304
P
V
N
G
R
P
R
T
G
L
K
T
S
Q
C
Site 40
T308
R
P
R
T
G
L
K
T
S
Q
C
S
S
P
S
Site 41
S309
P
R
T
G
L
K
T
S
Q
C
S
S
P
S
L
Site 42
S312
G
L
K
T
S
Q
C
S
S
P
S
L
S
A
S
Site 43
S313
L
K
T
S
Q
C
S
S
P
S
L
S
A
S
P
Site 44
S315
T
S
Q
C
S
S
P
S
L
S
A
S
P
G
S
Site 45
S317
Q
C
S
S
P
S
L
S
A
S
P
G
S
P
T
Site 46
S319
S
S
P
S
L
S
A
S
P
G
S
P
T
R
P
Site 47
S322
S
L
S
A
S
P
G
S
P
T
R
P
Q
I
R
Site 48
T324
S
A
S
P
G
S
P
T
R
P
Q
I
R
Q
K
Site 49
S342
K
P
L
Q
E
Q
L
S
V
N
Q
I
K
T
E
Site 50
T384
G
G
G
P
L
Q
A
T
S
S
P
Q
G
M
V
Site 51
S385
G
G
P
L
Q
A
T
S
S
P
Q
G
M
V
Q
Site 52
S386
G
P
L
Q
A
T
S
S
P
Q
G
M
V
Q
A
Site 53
T443
L
A
S
K
E
Q
E
T
I
N
A
S
P
I
Q
Site 54
S447
E
Q
E
T
I
N
A
S
P
I
Q
Q
G
G
H
Site 55
T470
P
L
V
D
Q
D
G
T
T
K
I
I
I
N
Y
Site 56
S478
T
K
I
I
I
N
Y
S
L
E
Q
P
S
Q
L
Site 57
S502
E
N
P
V
A
T
N
S
C
K
S
E
K
L
P
Site 58
T513
E
K
L
P
E
D
L
T
V
K
S
E
K
D
K
Site 59
S516
P
E
D
L
T
V
K
S
E
K
D
K
S
F
E
Site 60
S521
V
K
S
E
K
D
K
S
F
E
G
G
V
N
D
Site 61
S529
F
E
G
G
V
N
D
S
T
C
L
L
C
D
D
Site 62
T530
E
G
G
V
N
D
S
T
C
L
L
C
D
D
C
Site 63
Y550
A
L
P
E
L
K
H
Y
D
L
K
Q
P
T
Q
Site 64
T556
H
Y
D
L
K
Q
P
T
Q
P
P
P
L
P
A
Site 65
S571
A
E
A
E
K
P
E
S
S
V
S
S
A
T
G
Site 66
S572
E
A
E
K
P
E
S
S
V
S
S
A
T
G
D
Site 67
S574
E
K
P
E
S
S
V
S
S
A
T
G
D
G
N
Site 68
S575
K
P
E
S
S
V
S
S
A
T
G
D
G
N
L
Site 69
S583
A
T
G
D
G
N
L
S
P
S
Q
P
P
L
K
Site 70
S585
G
D
G
N
L
S
P
S
Q
P
P
L
K
N
L
Site 71
S607
Y
A
L
N
A
Q
P
S
A
E
E
L
S
K
I
Site 72
S638
K
M
Q
A
G
Q
I
S
V
Q
S
S
E
P
S
Site 73
S641
A
G
Q
I
S
V
Q
S
S
E
P
S
S
P
E
Site 74
S642
G
Q
I
S
V
Q
S
S
E
P
S
S
P
E
P
Site 75
S645
S
V
Q
S
S
E
P
S
S
P
E
P
G
K
V
Site 76
S646
V
Q
S
S
E
P
S
S
P
E
P
G
K
V
N
Site 77
S664
K
N
N
D
Q
P
Q
S
A
N
A
N
E
P
Q
Site 78
S673
N
A
N
E
P
Q
D
S
T
V
N
L
Q
S
P
Site 79
T674
A
N
E
P
Q
D
S
T
V
N
L
Q
S
P
L
Site 80
S679
D
S
T
V
N
L
Q
S
P
L
K
M
T
N
S
Site 81
T684
L
Q
S
P
L
K
M
T
N
S
P
V
L
P
V
Site 82
S686
S
P
L
K
M
T
N
S
P
V
L
P
V
G
S
Site 83
S693
S
P
V
L
P
V
G
S
T
T
N
G
S
R
S
Site 84
T694
P
V
L
P
V
G
S
T
T
N
G
S
R
S
S
Site 85
S698
V
G
S
T
T
N
G
S
R
S
S
T
P
S
P
Site 86
S700
S
T
T
N
G
S
R
S
S
T
P
S
P
S
P
Site 87
S701
T
T
N
G
S
R
S
S
T
P
S
P
S
P
L
Site 88
T702
T
N
G
S
R
S
S
T
P
S
P
S
P
L
N
Site 89
S704
G
S
R
S
S
T
P
S
P
S
P
L
N
L
S
Site 90
S706
R
S
S
T
P
S
P
S
P
L
N
L
S
S
S
Site 91
S711
S
P
S
P
L
N
L
S
S
S
R
N
T
Q
G
Site 92
S712
P
S
P
L
N
L
S
S
S
R
N
T
Q
G
Y
Site 93
S713
S
P
L
N
L
S
S
S
R
N
T
Q
G
Y
L
Site 94
T716
N
L
S
S
S
R
N
T
Q
G
Y
L
Y
T
A
Site 95
Y719
S
S
R
N
T
Q
G
Y
L
Y
T
A
E
G
A
Site 96
Y721
R
N
T
Q
G
Y
L
Y
T
A
E
G
A
Q
E
Site 97
S738
Q
V
E
P
L
D
L
S
L
P
K
Q
Q
G
E
Site 98
T751
G
E
L
L
E
R
S
T
I
T
S
V
Y
Q
N
Site 99
S754
L
E
R
S
T
I
T
S
V
Y
Q
N
S
V
Y
Site 100
Y756
R
S
T
I
T
S
V
Y
Q
N
S
V
Y
S
V
Site 101
Y761
S
V
Y
Q
N
S
V
Y
S
V
Q
E
E
P
L
Site 102
S762
V
Y
Q
N
S
V
Y
S
V
Q
E
E
P
L
N
Site 103
S771
Q
E
E
P
L
N
L
S
C
A
K
K
E
P
Q
Site 104
S781
K
K
E
P
Q
K
D
S
C
V
T
D
S
E
P
Site 105
S786
K
D
S
C
V
T
D
S
E
P
V
V
N
V
I
Site 106
T848
V
A
Y
T
Y
S
T
T
V
S
P
A
V
Q
E
Site 107
S850
Y
T
Y
S
T
T
V
S
P
A
V
Q
E
P
P
Site 108
T873
N
Q
D
E
R
Q
D
T
S
S
E
G
V
S
N
Site 109
S874
Q
D
E
R
Q
D
T
S
S
E
G
V
S
N
V
Site 110
S875
D
E
R
Q
D
T
S
S
E
G
V
S
N
V
E
Site 111
S879
D
T
S
S
E
G
V
S
N
V
E
D
Q
N
D
Site 112
S887
N
V
E
D
Q
N
D
S
D
S
T
P
P
K
K
Site 113
S889
E
D
Q
N
D
S
D
S
T
P
P
K
K
K
M
Site 114
T890
D
Q
N
D
S
D
S
T
P
P
K
K
K
M
R
Site 115
T899
P
K
K
K
M
R
K
T
E
N
G
M
Y
A
C
Site 116
Y904
R
K
T
E
N
G
M
Y
A
C
D
L
C
D
K
Site 117
S916
C
D
K
I
F
Q
K
S
S
S
L
L
R
H
K
Site 118
S917
D
K
I
F
Q
K
S
S
S
L
L
R
H
K
Y
Site 119
S918
K
I
F
Q
K
S
S
S
L
L
R
H
K
Y
E
Site 120
Y924
S
S
L
L
R
H
K
Y
E
H
T
G
K
R
P
Site 121
Y960
L
H
S
G
E
K
P
Y
Q
C
D
K
C
G
K
Site 122
S970
D
K
C
G
K
R
F
S
H
S
G
S
Y
S
Q
Site 123
S972
C
G
K
R
F
S
H
S
G
S
Y
S
Q
H
M
Site 124
S974
K
R
F
S
H
S
G
S
Y
S
Q
H
M
N
H
Site 125
Y985
H
M
N
H
R
Y
S
Y
C
K
R
E
A
E
E
Site 126
S995
R
E
A
E
E
R
D
S
T
E
Q
E
E
A
G
Site 127
T996
E
A
E
E
R
D
S
T
E
Q
E
E
A
G
P
Site 128
S1007
E
A
G
P
E
I
L
S
N
E
H
V
G
A
R
Site 129
S1016
E
H
V
G
A
R
A
S
P
S
Q
G
D
S
D
Site 130
S1018
V
G
A
R
A
S
P
S
Q
G
D
S
D
E
R
Site 131
S1022
A
S
P
S
Q
G
D
S
D
E
R
E
S
L
T
Site 132
S1027
G
D
S
D
E
R
E
S
L
T
R
E
E
D
E
Site 133
T1029
S
D
E
R
E
S
L
T
R
E
E
D
E
D
S
Site 134
S1036
T
R
E
E
D
E
D
S
E
K
E
E
E
E
E
Site 135
T1089
N
E
G
E
E
A
K
T
E
G
L
M
K
D
D
Site 136
S1100
M
K
D
D
R
A
E
S
Q
A
S
S
L
G
Q
Site 137
S1104
R
A
E
S
Q
A
S
S
L
G
Q
K
V
G
E
Site 138
S1113
G
Q
K
V
G
E
S
S
E
Q
V
S
E
E
K
Site 139
S1117
G
E
S
S
E
Q
V
S
E
E
K
T
N
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation