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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FDFT1
Full Name:
Squalene synthase
Alias:
DGPT; ERG9; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1; FDFT; FPP:FPP farnesyltransferase; SQS; Squalene synthase; SS
Type:
Transferase; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Endoplasmic reticulum; Oxidoreductase; EC 2.5.1.21
Mass (Da):
48115
Number AA:
417
UniProt ID:
P37268
International Prot ID:
IPI00020944
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004310
GO:0000287
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0008299
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
L
G
H
P
E
E
F
Y
N
L
V
R
F
R
I
Site 2
S35
M
P
K
M
D
Q
D
S
L
S
S
S
L
K
T
Site 3
S37
K
M
D
Q
D
S
L
S
S
S
L
K
T
C
Y
Site 4
S39
D
Q
D
S
L
S
S
S
L
K
T
C
Y
K
Y
Site 5
T42
S
L
S
S
S
L
K
T
C
Y
K
Y
L
N
Q
Site 6
Y46
S
L
K
T
C
Y
K
Y
L
N
Q
T
S
R
S
Site 7
S53
Y
L
N
Q
T
S
R
S
F
A
A
V
I
Q
A
Site 8
T87
D
T
L
E
D
D
M
T
I
S
V
E
K
K
V
Site 9
T127
Q
V
L
E
D
F
P
T
I
S
L
E
F
R
N
Site 10
S129
L
E
D
F
P
T
I
S
L
E
F
R
N
L
A
Site 11
T141
N
L
A
E
K
Y
Q
T
V
I
A
D
I
C
R
Site 12
Y171
S
E
Q
E
W
D
K
Y
C
H
Y
V
A
G
L
Site 13
S188
I
G
L
S
R
L
F
S
A
S
E
F
E
D
P
Site 14
T201
D
P
L
V
G
E
D
T
E
R
A
N
S
M
G
Site 15
S206
E
D
T
E
R
A
N
S
M
G
L
F
L
Q
K
Site 16
Y220
K
T
N
I
I
R
D
Y
L
E
D
Q
Q
G
G
Site 17
Y239
P
Q
E
V
W
S
R
Y
V
K
K
L
G
D
F
Site 18
T275
H
H
I
P
D
V
I
T
Y
L
S
R
L
R
N
Site 19
Y276
H
I
P
D
V
I
T
Y
L
S
R
L
R
N
Q
Site 20
S278
P
D
V
I
T
Y
L
S
R
L
R
N
Q
S
V
Site 21
Y341
V
K
A
I
I
Y
Q
Y
M
E
E
I
Y
H
R
Site 22
Y346
Y
Q
Y
M
E
E
I
Y
H
R
I
P
D
S
D
Site 23
S352
I
Y
H
R
I
P
D
S
D
P
S
S
S
K
T
Site 24
S355
R
I
P
D
S
D
P
S
S
S
K
T
R
Q
I
Site 25
S356
I
P
D
S
D
P
S
S
S
K
T
R
Q
I
I
Site 26
S357
P
D
S
D
P
S
S
S
K
T
R
Q
I
I
S
Site 27
T359
S
D
P
S
S
S
K
T
R
Q
I
I
S
T
I
Site 28
S364
S
K
T
R
Q
I
I
S
T
I
R
T
Q
N
L
Site 29
T365
K
T
R
Q
I
I
S
T
I
R
T
Q
N
L
P
Site 30
T368
Q
I
I
S
T
I
R
T
Q
N
L
P
N
C
Q
Site 31
S378
L
P
N
C
Q
L
I
S
R
S
H
Y
S
P
I
Site 32
Y382
Q
L
I
S
R
S
H
Y
S
P
I
Y
L
S
F
Site 33
T403
L
S
W
Q
Y
L
T
T
L
S
Q
V
T
E
D
Site 34
Y411
L
S
Q
V
T
E
D
Y
V
Q
T
G
E
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation