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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE6B
Full Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Alias:
CSNB3; EC 3.1.4.35; GMP-PDE beta; PDEB; Phosphodiesterase 6B, cGMP-specific, rod, beta; Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta
Type:
Enzyme - Phosphodiesterase - cyclic nucleotide
Mass (Da):
98407
Number AA:
854
UniProt ID:
P35913
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
Uniprot
OncoNet
Molecular Function:
GO:0047555
PhosphoSite+
KinaseNET
Biological Process:
GO:0007603
GO:0007165
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
S
E
E
Q
A
R
S
F
L
D
Q
N
P
D
Site 2
Y22
N
P
D
F
A
R
Q
Y
F
G
K
K
L
S
P
Site 3
S28
Q
Y
F
G
K
K
L
S
P
E
N
V
A
A
A
Site 4
S46
G
C
P
P
D
C
D
S
L
R
D
L
C
Q
V
Site 5
S93
L
L
Q
A
D
R
C
S
L
F
M
Y
R
Q
R
Site 6
Y97
D
R
C
S
L
F
M
Y
R
Q
R
N
G
V
A
Site 7
S162
A
E
C
P
H
F
S
S
F
A
D
E
L
T
D
Site 8
T168
S
S
F
A
D
E
L
T
D
Y
K
T
K
N
M
Site 9
Y170
F
A
D
E
L
T
D
Y
K
T
K
N
M
L
A
Site 10
T172
D
E
L
T
D
Y
K
T
K
N
M
L
A
T
P
Site 11
T178
K
T
K
N
M
L
A
T
P
I
M
N
G
K
D
Site 12
Y227
L
K
I
Y
H
L
S
Y
L
H
N
C
E
T
R
Site 13
T233
S
Y
L
H
N
C
E
T
R
R
G
Q
V
L
L
Site 14
Y262
R
Q
F
H
K
A
F
Y
T
V
R
A
Y
L
N
Site 15
T263
Q
F
H
K
A
F
Y
T
V
R
A
Y
L
N
C
Site 16
Y267
A
F
Y
T
V
R
A
Y
L
N
C
E
R
Y
S
Site 17
T281
S
V
G
L
L
D
M
T
K
E
K
E
F
F
D
Site 18
S297
W
S
V
L
M
G
E
S
Q
P
Y
S
G
P
R
Site 19
Y300
L
M
G
E
S
Q
P
Y
S
G
P
R
T
P
D
Site 20
S301
M
G
E
S
Q
P
Y
S
G
P
R
T
P
D
G
Site 21
T305
Q
P
Y
S
G
P
R
T
P
D
G
R
E
I
V
Site 22
Y319
V
F
Y
K
V
I
D
Y
V
L
H
G
K
E
E
Site 23
T332
E
E
I
K
V
I
P
T
P
S
A
D
H
W
A
Site 24
S376
Q
E
G
A
L
D
D
S
G
W
L
I
K
N
V
Site 25
T400
E
E
I
V
G
V
A
T
F
Y
N
R
K
D
G
Site 26
Y402
I
V
G
V
A
T
F
Y
N
R
K
D
G
K
P
Site 27
S420
Q
D
E
V
L
M
E
S
L
T
Q
F
L
G
W
Site 28
Y435
S
V
M
N
T
D
T
Y
D
K
M
N
K
L
E
Site 29
Y454
I
A
Q
D
M
V
L
Y
H
V
K
C
D
R
D
Site 30
T498
E
E
L
P
G
P
T
T
F
D
I
Y
E
F
H
Site 31
Y502
G
P
T
T
F
D
I
Y
E
F
H
F
S
D
L
Site 32
Y525
K
C
G
I
Q
M
Y
Y
E
L
G
V
V
R
K
Site 33
S548
V
R
F
L
F
S
I
S
K
G
Y
R
R
I
T
Site 34
Y551
L
F
S
I
S
K
G
Y
R
R
I
T
Y
H
N
Site 35
Y556
K
G
Y
R
R
I
T
Y
H
N
W
R
H
G
F
Site 36
S580
L
M
T
G
K
L
K
S
Y
Y
T
D
L
E
A
Site 37
Y582
T
G
K
L
K
S
Y
Y
T
D
L
E
A
F
A
Site 38
Y608
H
R
G
T
N
N
L
Y
Q
M
K
S
Q
N
P
Site 39
S612
N
N
L
Y
Q
M
K
S
Q
N
P
L
A
K
L
Site 40
S638
E
F
G
K
F
L
L
S
E
E
T
L
N
I
Y
Site 41
Y645
S
E
E
T
L
N
I
Y
Q
N
L
N
R
R
Q
Site 42
Y689
I
V
D
E
S
K
N
Y
Q
D
K
K
S
W
V
Site 43
S694
K
N
Y
Q
D
K
K
S
W
V
E
Y
L
S
L
Site 44
Y698
D
K
K
S
W
V
E
Y
L
S
L
E
T
T
R
Site 45
S700
K
S
W
V
E
Y
L
S
L
E
T
T
R
K
E
Site 46
T704
E
Y
L
S
L
E
T
T
R
K
E
I
V
M
A
Site 47
T749
E
Q
G
D
L
E
R
T
V
L
D
Q
Q
P
I
Site 48
Y783
D
F
V
C
T
F
V
Y
K
E
F
S
R
F
H
Site 49
Y814
W
K
A
L
A
D
E
Y
E
A
K
V
K
A
L
Site 50
S848
N
G
G
P
A
P
K
S
S
T
C
C
I
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation