PhosphoNET

           
Protein Info 
   
Short Name:  K2
Full Name:  Keratin, type II cytoskeletal 2 epidermal
Alias:  CK 2e; Cytokeratin-2e; Epidermal ichthyosis bullosa of Siemens; K22E; K2e; Keratin 2; KRT2A; KRT2E; KRTE
Type:  Cytoskeletal protein
Mass (Da):  65433
Number AA:  639
UniProt ID:  P35908
International Prot ID:  IPI00021304
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0045095   Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0005200   PhosphoSite+ KinaseNET
Biological Process:  GO:0031424  GO:0032980  GO:0051546 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MSCQISCKSRGRG
Site 2S9SCQISCKSRGRGGGG
Site 3S30SSGSAVVSGGSRRST
Site 4S33SAVVSGGSRRSTSSF
Site 5S36VSGGSRRSTSSFSCL
Site 6T37SGGSRRSTSSFSCLS
Site 7S38GGSRRSTSSFSCLSR
Site 8S39GSRRSTSSFSCLSRH
Site 9S41RRSTSSFSCLSRHGG
Site 10S44TSSFSCLSRHGGGGG
Site 11S60FGGGGFGSRSLVGLG
Site 12S62GGGFGSRSLVGLGGT
Site 13S100GGGFGGGSSFGGGSG
Site 14S101GGFGGGSSFGGGSGF
Site 15S106GSSFGGGSGFSGGGF
Site 16Y146GGFGPGGYPGGIHEV
Site 17S154PGGIHEVSVNQSLLQ
Site 18S158HEVSVNQSLLQPLNV
Site 19T184QEREQIKTLNNKFAS
Site 20S191TLNNKFASFIDKVRF
Site 21S235IFQGYIDSLKRYLDG
Site 22Y239YIDSLKRYLDGLTAE
Site 23T244KRYLDGLTAERTSQN
Site 24T248DGLTAERTSQNSELN
Site 25S249GLTAERTSQNSELNN
Site 26S252AERTSQNSELNNMQD
Site 27Y264MQDLVEDYKKKYEDE
Site 28Y268VEDYKKKYEDEINKR
Site 29Y293KKDVDNAYMIKVELQ
Site 30S336TDTNVILSMDNSRNL
Site 31S340VILSMDNSRNLDLDS
Site 32S347SRNLDLDSIIAEVKA
Site 33Y356IAEVKAQYEEIAQRS
Site 34Y371KEEAEALYHSKYEEL
Site 35S373EAEALYHSKYEELQV
Site 36Y375EALYHSKYEELQVTV
Site 37T381KYEELQVTVGRHGDS
Site 38S388TVGRHGDSLKEIKIE
Site 39Y463LARLLRDYQELMNVK
Site 40Y480LDVEIATYRKLLEGE
Site 41S492EGEECRMSGDLSSNV
Site 42S497RMSGDLSSNVTVSVT
Site 43T500GDLSSNVTVSVTSST
Site 44T504SNVTVSVTSSTISSN
Site 45S509SVTSSTISSNVASKA
Site 46S521SKAAFGGSGGRGSSS
Site 47S526GGSGGRGSSSGGGYS
Site 48S527GSGGRGSSSGGGYSS
Site 49S528SGGRGSSSGGGYSSG
Site 50Y532GSSSGGGYSSGSSSY
Site 51S533SSSGGGYSSGSSSYG
Site 52S534SSGGGYSSGSSSYGS
Site 53S536GGGYSSGSSSYGSGG
Site 54S537GGYSSGSSSYGSGGR
Site 55S538GYSSGSSSYGSGGRQ
Site 56S541SGSSSYGSGGRQSGS
Site 57S546YGSGGRQSGSRGGSG
Site 58S548SGGRQSGSRGGSGGG
Site 59S552QSGSRGGSGGGGSIS
Site 60S557GGSGGGGSISGGGYG
Site 61S559SGGGGSISGGGYGSG
Site 62Y563GSISGGGYGSGGGSG
Site 63S565ISGGGYGSGGGSGGR
Site 64S569GYGSGGGSGGRYGSG
Site 65Y573GGGSGGRYGSGGGSK
Site 66S575GSGGRYGSGGGSKGG
Site 67S579RYGSGGGSKGGSISG
Site 68S583GGGSKGGSISGGGYG
Site 69S585GSKGGSISGGGYGSG
Site 70Y589GSISGGGYGSGGGKH
Site 71S591ISGGGYGSGGGKHSS
Site 72S597GSGGGKHSSGGGSRG
Site 73S598SGGGKHSSGGGSRGG
Site 74S602KHSSGGGSRGGSSSG
Site 75S606GGGSRGGSSSGGGYG
Site 76S607GGSRGGSSSGGGYGS
Site 77S608GSRGGSSSGGGYGSG
Site 78Y612GSSSGGGYGSGGGGS
Site 79S614SSGGGYGSGGGGSSS
Site 80S619YGSGGGGSSSVKGSS
Site 81S620GSGGGGSSSVKGSSG
Site 82S621SGGGGSSSVKGSSGE
Site 83S625GSSSVKGSSGEAFGS
Site 84S626SSSVKGSSGEAFGSS
Site 85S632SSGEAFGSSVTFSFR
Site 86S633SGEAFGSSVTFSFR_
Site 87T635EAFGSSVTFSFR___
Site 88S637FGSSVTFSFR_____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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