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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHKA
Full Name:
Choline kinase alpha
Alias:
CHETK-alpha;Ethanolamine kinase;
Type:
Mass (Da):
52249
Number AA:
457
UniProt ID:
P35790
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
G
Q
Q
R
D
A
A
S
D
L
E
S
K
Q
L
Site 2
S45
D
A
A
S
D
L
E
S
K
Q
L
G
G
Q
Q
Site 3
T87
D
E
Q
P
E
P
R
T
R
R
R
A
Y
L
W
Site 4
Y92
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
Site 5
S114
R
E
D
E
F
H
I
S
V
I
R
G
G
L
S
Site 6
S128
S
N
M
L
F
Q
C
S
L
P
D
T
T
A
T
Site 7
T132
F
Q
C
S
L
P
D
T
T
A
T
L
G
D
E
Site 8
T135
S
L
P
D
T
T
A
T
L
G
D
E
P
R
K
Site 9
S156
G
A
I
L
Q
M
R
S
C
N
K
E
G
S
E
Site 10
Y197
R
S
L
G
P
K
L
Y
G
I
F
P
Q
G
R
Site 11
T216
I
P
S
R
R
L
D
T
E
E
L
S
L
P
D
Site 12
S220
R
L
D
T
E
E
L
S
L
P
D
I
S
A
E
Site 13
S225
E
L
S
L
P
D
I
S
A
E
I
A
E
K
M
Site 14
T234
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
Site 15
S269
R
I
K
F
T
E
E
S
R
I
K
K
L
H
K
Site 16
S279
K
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
Site 17
Y280
K
L
H
K
L
L
S
Y
N
L
P
L
E
L
E
Site 18
S291
L
E
L
E
N
L
R
S
L
L
E
S
T
P
S
Site 19
S321
L
L
E
G
R
E
N
S
E
K
Q
K
L
M
L
Site 20
Y333
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
Site 21
Y336
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
Site 22
Y338
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
Site 23
Y356
E
W
M
Y
D
Y
S
Y
E
K
Y
P
F
F
R
Site 24
Y359
Y
D
Y
S
Y
E
K
Y
P
F
F
R
A
N
I
Site 25
Y369
F
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
Site 26
S381
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
Site 27
Y382
Q
L
H
F
I
S
S
Y
L
P
A
F
Q
N
D
Site 28
S394
Q
N
D
F
E
N
L
S
T
E
E
K
S
I
I
Site 29
T395
N
D
F
E
N
L
S
T
E
E
K
S
I
I
K
Site 30
S399
N
L
S
T
E
E
K
S
I
I
K
E
E
M
L
Site 31
S431
S
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
Site 32
S432
I
V
Q
A
K
I
S
S
I
E
F
G
Y
M
D
Site 33
Y437
I
S
S
I
E
F
G
Y
M
D
Y
A
Q
A
R
Site 34
Y440
I
E
F
G
Y
M
D
Y
A
Q
A
R
F
D
A
Site 35
Y448
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation