PhosphoNET

           
Protein Info 
   
Short Name:  TCF2
Full Name:  Hepatocyte nuclear factor 1-beta
Alias:  FJHN; HNF1B; HNF-1B; HNF1beta; HNF-1beta; HNF2; Homeoprotein LFB3; LFB3; LF-B3; MODY5; TCF-2; Transcription factor 2; Transcription factor 2, hepatic; Variant hepatic nuclear factor; Variant hepatic nuclear factor 1; VHNF1
Type:  Nucleolus, Nucleus protein
Mass (Da):  61324
Number AA:  557
UniProt ID:  P35680
International Prot ID:  IPI00020078
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0042803  GO:0043565  GO:0016563 PhosphoSite+ KinaseNET
Biological Process:  GO:0031018  GO:0048806  GO:0001822 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S3_____MVSKLTSLQQ
Site 2T45NFGVKLETLPLSPGS
Site 3S49KLETLPLSPGSGAEP
Site 4T58GSGAEPDTKPVFHTL
Site 5S75GHAKGRLSGDEGSED
Site 6S80RLSGDEGSEDGDDYD
Site 7Y86GSEDGDDYDTPPILK
Site 8T88EDGDDYDTPPILKEL
Site 9S115AEVDRMLSEDPWRAA
Site 10Y128AAKMIKGYMQQHNIP
Site 11T143QREVVDVTGLNQSHL
Site 12S148DVTGLNQSHLSQHLN
Site 13S151GLNQSHLSQHLNKGT
Site 14T158SQHLNKGTPMKTQKR
Site 15T162NKGTPMKTQKRAALY
Site 16T170QKRAALYTWYVRKQR
Site 17Y172RAALYTWYVRKQREI
Site 18T186ILRQFNQTVQSSGNM
Site 19T194VQSSGNMTDKSSQDQ
Site 20S197SGNMTDKSSQDQLLF
Site 21S198GNMTDKSSQDQLLFL
Site 22S210LFLFPEFSQQSHGPG
Site 23S213FPEFSQQSHGPGQSD
Site 24S219QSHGPGQSDDACSEP
Site 25S242RFKWGPASQQILYQA
Site 26Y247PASQQILYQAYDRQK
Site 27Y250QQILYQAYDRQKNPS
Site 28S257YDRQKNPSKEEREAL
Site 29S279ECLQRGVSPSKAHGL
Site 30S281LQRGVSPSKAHGLGS
Site 31T292GLGSNLVTEVRVYNW
Site 32Y297LVTEVRVYNWFANRR
Site 33Y318QKLAMDAYSSNQTHS
Site 34S319KLAMDAYSSNQTHSL
Site 35T323DAYSSNQTHSLNPLL
Site 36S325YSSNQTHSLNPLLSH
Site 37S331HSLNPLLSHGSPHHQ
Site 38S334NPLLSHGSPHHQPSS
Site 39S340GSPHHQPSSSPPNKL
Site 40S341SPHHQPSSSPPNKLS
Site 41S342PHHQPSSSPPNKLSG
Site 42S348SSPPNKLSGVRYSQQ
Site 43Y352NKLSGVRYSQQGNNE
Site 44S353KLSGVRYSQQGNNEI
Site 45S362QGNNEITSSSTISHH
Site 46S363GNNEITSSSTISHHG
Site 47S364NNEITSSSTISHHGN
Site 48S367ITSSSTISHHGNSAM
Site 49T376HGNSAMVTSQSVLQQ
Site 50S377GNSAMVTSQSVLQQV
Site 51S385QSVLQQVSPASLDPG
Site 52S388LQQVSPASLDPGHNL
Site 53S397DPGHNLLSPDGKMIS
Site 54S404SPDGKMISVSGGGLP
Site 55S421STLTNIHSLSHHNPQ
Site 56S423LTNIHSLSHHNPQQS
Site 57S451IAQSLNTSQAQSVPV
Site 58S475ALQPVQFSQQLHSPH
Site 59S480QFSQQLHSPHQQPLM
Site 60S490QQPLMQQSPGSHMAQ
Site 61S493LMQQSPGSHMAQQPF
Site 62Y522HKQEPPQYSHTSRFP
Site 63S523KQEPPQYSHTSRFPS
Site 64T525EPPQYSHTSRFPSAM
Site 65S526PPQYSHTSRFPSAMV
Site 66S530SHTSRFPSAMVVTDT
Site 67T542TDTSSISTLTNMSSS
Site 68T544TSSISTLTNMSSSKQ
Site 69S547ISTLTNMSSSKQCPL
Site 70S548STLTNMSSSKQCPLQ
Site 71S549TLTNMSSSKQCPLQA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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