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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIMP3
Full Name:
Metalloproteinase inhibitor 3
Alias:
metalloproteinase inhibitor 3; MIG-5; SFD; TIMP metallopeptidase inhibitor 3; TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); TIMP-3; tissue inhibitor of metalloproteinases 3
Type:
Mass (Da):
24140
Number AA:
211
UniProt ID:
P35625
International Prot ID:
IPI00218247
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008191
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051045
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
A
E
A
C
T
C
S
P
S
H
P
Q
D
A
Site 2
T84
P
H
V
Q
Y
I
H
T
E
A
S
E
S
L
C
Site 3
S87
Q
Y
I
H
T
E
A
S
E
S
L
C
G
L
K
Site 4
S89
I
H
T
E
A
S
E
S
L
C
G
L
K
L
E
Site 5
Y100
L
K
L
E
V
N
K
Y
Q
Y
L
L
T
G
R
Site 6
Y102
L
E
V
N
K
Y
Q
Y
L
L
T
G
R
V
Y
Site 7
T105
N
K
Y
Q
Y
L
L
T
G
R
V
Y
D
G
K
Site 8
Y109
Y
L
L
T
G
R
V
Y
D
G
K
M
Y
T
G
Site 9
T128
V
E
R
W
D
Q
L
T
L
S
Q
R
K
G
L
Site 10
S130
R
W
D
Q
L
T
L
S
Q
R
K
G
L
N
Y
Site 11
Y137
S
Q
R
K
G
L
N
Y
R
Y
H
L
G
C
N
Site 12
Y139
R
K
G
L
N
Y
R
Y
H
L
G
C
N
C
K
Site 13
Y174
D
M
L
S
N
F
G
Y
P
G
Y
Q
S
K
H
Site 14
Y177
S
N
F
G
Y
P
G
Y
Q
S
K
H
Y
A
C
Site 15
Y182
P
G
Y
Q
S
K
H
Y
A
C
I
R
Q
K
G
Site 16
Y195
K
G
G
Y
C
S
W
Y
R
G
W
A
P
P
D
Site 17
S204
G
W
A
P
P
D
K
S
I
I
N
A
T
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation