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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GDE
Full Name:
Glycogen debranching enzyme
Alias:
AGL; Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; Amylo-1,6-glucosidase; Dextrin 6-alpha-D-glucosidase; Glycogen debrancher; Glycogen storage disease type III; Oligo-1,4-1,4-glucantransferase
Type:
Ubiquitin conjugating system; Transferase; EC 3.2.1.33; EC 2.4.1.25; Carbohydrate Metabolism - starch and sucrose; Hydrolase
Mass (Da):
174764
Number AA:
1532
UniProt ID:
P35573
International Prot ID:
IPI00514126
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0043033
Uniprot
OncoNet
Molecular Function:
GO:0004134
GO:0004135
GO:0043169
PhosphoSite+
KinaseNET
Biological Process:
GO:0005978
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
E
M
E
K
L
E
K
T
L
F
R
L
E
Q
G
Site 2
Y29
L
F
R
L
E
Q
G
Y
E
L
Q
F
R
L
G
Site 3
Y47
Q
G
K
A
V
T
V
Y
T
N
Y
P
F
P
G
Site 4
T48
G
K
A
V
T
V
Y
T
N
Y
P
F
P
G
E
Site 5
Y50
A
V
T
V
Y
T
N
Y
P
F
P
G
E
T
F
Site 6
T56
N
Y
P
F
P
G
E
T
F
N
R
E
K
F
R
Site 7
S64
F
N
R
E
K
F
R
S
L
D
W
E
N
P
T
Site 8
T71
S
L
D
W
E
N
P
T
E
R
E
D
D
S
D
Site 9
S77
P
T
E
R
E
D
D
S
D
K
Y
C
K
L
N
Site 10
Y80
R
E
D
D
S
D
K
Y
C
K
L
N
L
Q
Q
Site 11
S90
L
N
L
Q
Q
S
G
S
F
Q
Y
Y
F
L
Q
Site 12
Y94
Q
S
G
S
F
Q
Y
Y
F
L
Q
G
N
E
K
Site 13
S171
Q
T
L
G
L
S
R
S
C
Y
S
L
A
N
Q
Site 14
Y173
L
G
L
S
R
S
C
Y
S
L
A
N
Q
L
E
Site 15
S174
G
L
S
R
S
C
Y
S
L
A
N
Q
L
E
L
Site 16
Y192
F
S
R
P
N
R
K
Y
T
W
N
D
V
G
Q
Site 17
T193
S
R
P
N
R
K
Y
T
W
N
D
V
G
Q
L
Site 18
Y236
Q
E
H
P
E
C
A
Y
N
L
V
N
S
P
H
Site 19
S258
D
R
A
L
W
R
F
S
C
D
V
A
E
G
K
Site 20
S283
E
N
D
H
H
M
N
S
I
R
K
I
I
W
E
Site 21
T318
E
Q
F
R
R
L
L
T
Q
E
N
R
R
V
T
Site 22
T325
T
Q
E
N
R
R
V
T
K
S
D
P
N
Q
H
Site 23
S327
E
N
R
R
V
T
K
S
D
P
N
Q
H
L
T
Site 24
T334
S
D
P
N
Q
H
L
T
I
I
Q
D
P
E
Y
Site 25
Y341
T
I
I
Q
D
P
E
Y
R
R
F
G
C
T
V
Site 26
T356
D
M
N
I
A
L
T
T
F
I
P
H
D
K
G
Site 27
S383
K
R
M
E
E
L
N
S
E
K
H
R
L
I
N
Site 28
T420
G
P
K
L
G
P
V
T
R
K
H
P
L
V
T
Site 29
Y429
K
H
P
L
V
T
R
Y
F
T
F
P
F
E
E
Site 30
T431
P
L
V
T
R
Y
F
T
F
P
F
E
E
I
D
Site 31
S440
P
F
E
E
I
D
F
S
M
E
E
S
M
I
H
Site 32
S476
R
N
F
A
E
P
G
S
E
V
Y
L
R
R
E
Site 33
Y479
A
E
P
G
S
E
V
Y
L
R
R
E
L
I
C
Site 34
Y504
N
K
P
E
D
C
P
Y
L
W
A
H
M
K
K
Site 35
Y512
L
W
A
H
M
K
K
Y
T
E
I
T
A
T
Y
Site 36
T518
K
Y
T
E
I
T
A
T
Y
F
Q
G
V
R
L
Site 37
Y519
Y
T
E
I
T
A
T
Y
F
Q
G
V
R
L
D
Site 38
S530
V
R
L
D
N
C
H
S
T
P
L
H
V
A
E
Site 39
T531
R
L
D
N
C
H
S
T
P
L
H
V
A
E
Y
Site 40
S582
S
L
I
R
E
A
M
S
A
Y
N
S
H
E
E
Site 41
Y584
I
R
E
A
M
S
A
Y
N
S
H
E
E
G
R
Site 42
S586
E
A
M
S
A
Y
N
S
H
E
E
G
R
L
V
Site 43
Y594
H
E
E
G
R
L
V
Y
R
Y
G
G
E
P
V
Site 44
Y596
E
G
R
L
V
Y
R
Y
G
G
E
P
V
G
S
Site 45
S603
Y
G
G
E
P
V
G
S
F
V
Q
P
C
L
R
Site 46
Y638
P
I
V
H
R
S
A
Y
D
A
L
P
S
T
T
Site 47
S656
M
A
C
C
A
S
G
S
T
R
G
Y
D
E
L
Site 48
Y660
A
S
G
S
T
R
G
Y
D
E
L
V
P
H
Q
Site 49
S669
E
L
V
P
H
Q
I
S
V
V
S
E
E
R
F
Site 50
S672
P
H
Q
I
S
V
V
S
E
E
R
F
Y
T
K
Site 51
Y677
V
V
S
E
E
R
F
Y
T
K
W
N
P
E
A
Site 52
T678
V
S
E
E
R
F
Y
T
K
W
N
P
E
A
L
Site 53
S687
W
N
P
E
A
L
P
S
N
T
G
E
V
N
F
Site 54
Y721
A
K
G
F
I
Q
V
Y
V
D
Q
V
D
E
D
Site 55
S738
A
V
T
R
H
S
P
S
I
H
Q
S
V
V
A
Site 56
S742
H
S
P
S
I
H
Q
S
V
V
A
V
S
R
T
Site 57
T756
T
A
F
R
N
P
K
T
S
F
Y
S
K
E
V
Site 58
S757
A
F
R
N
P
K
T
S
F
Y
S
K
E
V
P
Site 59
T786
A
R
T
I
E
R
N
T
K
P
Y
R
K
D
E
Site 60
Y789
I
E
R
N
T
K
P
Y
R
K
D
E
N
S
I
Site 61
S795
P
Y
R
K
D
E
N
S
I
N
G
T
P
D
I
Site 62
T799
D
E
N
S
I
N
G
T
P
D
I
T
V
E
I
Site 63
T803
I
N
G
T
P
D
I
T
V
E
I
R
E
H
I
Site 64
T868
G
I
L
R
N
H
L
T
Q
F
S
P
H
F
K
Site 65
S871
R
N
H
L
T
Q
F
S
P
H
F
K
S
G
S
Site 66
S876
Q
F
S
P
H
F
K
S
G
S
L
A
V
D
N
Site 67
S878
S
P
H
F
K
S
G
S
L
A
V
D
N
A
D
Site 68
S894
I
L
K
I
P
F
A
S
L
A
S
R
L
T
L
Site 69
Y909
A
E
L
N
Q
I
L
Y
R
C
E
S
E
E
K
Site 70
S913
Q
I
L
Y
R
C
E
S
E
E
K
E
D
G
G
Site 71
Y923
K
E
D
G
G
G
C
Y
D
I
P
N
W
S
A
Site 72
Y933
P
N
W
S
A
L
K
Y
A
G
L
Q
G
L
M
Site 73
Y969
S
G
D
W
M
I
D
Y
V
S
N
R
L
I
S
Site 74
S976
Y
V
S
N
R
L
I
S
R
S
G
T
I
A
E
Site 75
S978
S
N
R
L
I
S
R
S
G
T
I
A
E
V
G
Site 76
T980
R
L
I
S
R
S
G
T
I
A
E
V
G
K
W
Site 77
Y1001
Y
L
K
Q
I
P
R
Y
L
I
P
C
Y
F
D
Site 78
T1021
A
Y
T
T
L
L
D
T
A
W
K
Q
M
S
S
Site 79
S1028
T
A
W
K
Q
M
S
S
F
V
Q
N
G
S
T
Site 80
S1034
S
S
F
V
Q
N
G
S
T
F
V
K
H
L
S
Site 81
Y1068
P
A
L
M
D
V
P
Y
R
L
N
E
I
T
K
Site 82
T1074
P
Y
R
L
N
E
I
T
K
E
K
E
Q
C
C
Site 83
S1083
E
K
E
Q
C
C
V
S
L
A
A
G
L
P
H
Site 84
Y1117
I
L
L
I
T
G
R
Y
V
E
A
R
N
I
I
Site 85
T1130
I
I
L
A
F
A
G
T
L
R
H
G
L
I
P
Site 86
Y1145
N
L
L
G
E
G
I
Y
A
R
Y
N
C
R
D
Site 87
Y1148
G
E
G
I
Y
A
R
Y
N
C
R
D
A
V
W
Site 88
S1180
D
I
L
K
C
P
V
S
R
M
Y
P
T
D
D
Site 89
Y1183
K
C
P
V
S
R
M
Y
P
T
D
D
S
A
P
Site 90
T1185
P
V
S
R
M
Y
P
T
D
D
S
A
P
L
P
Site 91
S1188
R
M
Y
P
T
D
D
S
A
P
L
P
A
G
T
Site 92
T1245
T
A
G
V
D
E
E
T
G
F
V
Y
G
G
N
Site 93
Y1249
D
E
E
T
G
F
V
Y
G
G
N
R
F
N
C
Site 94
T1277
R
N
R
G
I
P
A
T
P
R
D
G
S
A
V
Site 95
S1290
A
V
E
I
V
G
L
S
K
S
A
V
R
W
L
Site 96
Y1308
S
K
K
N
I
F
P
Y
H
E
V
T
V
K
R
Site 97
T1312
I
F
P
Y
H
E
V
T
V
K
R
H
G
K
A
Site 98
S1342
F
E
K
L
F
H
V
S
E
D
P
S
D
L
N
Site 99
S1346
F
H
V
S
E
D
P
S
D
L
N
E
K
H
P
Site 100
Y1362
L
V
H
K
R
G
I
Y
K
D
S
Y
G
A
S
Site 101
S1365
K
R
G
I
Y
K
D
S
Y
G
A
S
S
P
W
Site 102
Y1366
R
G
I
Y
K
D
S
Y
G
A
S
S
P
W
C
Site 103
S1370
K
D
S
Y
G
A
S
S
P
W
C
D
Y
Q
L
Site 104
Y1375
A
S
S
P
W
C
D
Y
Q
L
R
P
N
F
T
Site 105
T1416
L
G
P
L
G
M
K
T
L
D
P
D
D
M
V
Site 106
Y1424
L
D
P
D
D
M
V
Y
C
G
I
Y
D
N
A
Site 107
Y1428
D
M
V
Y
C
G
I
Y
D
N
A
L
D
N
D
Site 108
Y1437
N
A
L
D
N
D
N
Y
N
L
A
K
G
F
N
Site 109
S1466
L
R
A
K
L
Y
F
S
R
L
M
G
P
E
T
Site 110
Y1489
K
N
V
L
S
R
H
Y
V
H
L
E
R
S
P
Site 111
S1495
H
Y
V
H
L
E
R
S
P
W
K
G
L
P
E
Site 112
Y1510
L
T
N
E
N
A
Q
Y
C
P
F
S
C
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation