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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCK1
Full Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Alias:
PEPCK1; PEPCK-C; Phosphoenolpyruvate carboxykinase 1 (soluble); Phosphoenolpyruvate carboxylase; PPCKC
Type:
Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.1.32; Kinase (non-protein); Lyase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle
Mass (Da):
69195
Number AA:
622
UniProt ID:
P35558
International Prot ID:
IPI00292709
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0031406
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006094
GO:0042593
GO:0046327
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
L
Q
N
G
L
N
L
S
A
K
V
V
Q
G
S
Site 2
S19
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
Site 3
S22
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
Site 4
S49
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
Site 5
Y72
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
Site 6
T80
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
Site 7
S90
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
Site 8
T92
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
Site 9
T102
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
Site 10
T108
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
Site 11
S111
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
Site 12
S118
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
Site 13
T178
R
I
M
T
R
M
G
T
P
V
L
E
A
V
G
Site 14
S230
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
Site 15
S233
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
Site 16
Y235
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
Site 17
S239
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
Site 18
S252
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
Site 19
Y279
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
Site 20
S286
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
Site 21
S340
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
Site 22
T350
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
Site 23
S385
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
Site 24
S392
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
Site 25
S393
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
Site 26
S404
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Site 27
T408
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
Site 28
Y493
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
Site 29
T553
G
K
A
S
T
K
L
T
P
I
G
Y
I
P
K
Site 30
Y557
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
Site 31
Y595
E
V
E
D
I
E
K
Y
L
E
D
Q
V
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation