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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GCK
Full Name:
Glucokinase
Alias:
Hexokinase type IV;Hexokinase-4;Hexokinase-D
Type:
Mass (Da):
52191
Number AA:
465
UniProt ID:
P35557
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T49
D
R
G
L
R
L
E
T
H
E
E
A
S
V
K
Site 2
T60
A
S
V
K
M
L
P
T
Y
V
R
S
T
P
E
Site 3
Y61
S
V
K
M
L
P
T
Y
V
R
S
T
P
E
G
Site 4
S64
M
L
P
T
Y
V
R
S
T
P
E
G
S
E
V
Site 5
T65
L
P
T
Y
V
R
S
T
P
E
G
S
E
V
G
Site 6
S76
S
E
V
G
D
F
L
S
L
D
L
G
G
T
N
Site 7
Y108
V
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
Site 8
S109
K
T
K
H
Q
M
Y
S
I
P
E
D
A
M
T
Site 9
T149
K
K
L
P
L
G
F
T
F
S
F
P
V
R
H
Site 10
S151
L
P
L
G
F
T
F
S
F
P
V
R
H
E
D
Site 11
S263
E
W
G
A
F
G
D
S
G
E
L
D
E
F
L
Site 12
Y273
L
D
E
F
L
L
E
Y
D
R
L
V
D
E
S
Site 13
S280
Y
D
R
L
V
D
E
S
S
A
N
P
G
Q
Q
Site 14
S281
D
R
L
V
D
E
S
S
A
N
P
G
Q
Q
L
Site 15
Y289
A
N
P
G
Q
Q
L
Y
E
K
L
I
G
G
K
Site 16
Y297
E
K
L
I
G
G
K
Y
M
G
E
L
V
R
L
Site 17
T326
E
A
S
E
Q
L
R
T
R
G
A
F
E
T
R
Site 18
T332
R
T
R
G
A
F
E
T
R
F
V
S
Q
V
E
Site 19
S336
A
F
E
T
R
F
V
S
Q
V
E
S
D
T
G
Site 20
S340
R
F
V
S
Q
V
E
S
D
T
G
D
R
K
Q
Site 21
T342
V
S
Q
V
E
S
D
T
G
D
R
K
Q
I
Y
Site 22
Y349
T
G
D
R
K
Q
I
Y
N
I
L
S
T
L
G
Site 23
S353
K
Q
I
Y
N
I
L
S
T
L
G
L
R
P
S
Site 24
S360
S
T
L
G
L
R
P
S
T
T
D
C
D
I
V
Site 25
T361
T
L
G
L
R
P
S
T
T
D
C
D
I
V
R
Site 26
T362
L
G
L
R
P
S
T
T
D
C
D
I
V
R
R
Site 27
S373
I
V
R
R
A
C
E
S
V
S
T
R
A
A
H
Site 28
S375
R
R
A
C
E
S
V
S
T
R
A
A
H
M
C
Site 29
T376
R
A
C
E
S
V
S
T
R
A
A
H
M
C
S
Site 30
S396
V
I
N
R
M
R
E
S
R
S
E
D
V
M
R
Site 31
S398
N
R
M
R
E
S
R
S
E
D
V
M
R
I
T
Site 32
S411
I
T
V
G
V
D
G
S
V
Y
K
L
H
P
S
Site 33
Y413
V
G
V
D
G
S
V
Y
K
L
H
P
S
F
K
Site 34
S418
S
V
Y
K
L
H
P
S
F
K
E
R
F
H
A
Site 35
S426
F
K
E
R
F
H
A
S
V
R
R
L
T
P
S
Site 36
T431
H
A
S
V
R
R
L
T
P
S
C
E
I
T
F
Site 37
S433
S
V
R
R
L
T
P
S
C
E
I
T
F
I
E
Site 38
T437
L
T
P
S
C
E
I
T
F
I
E
S
E
E
G
Site 39
S441
C
E
I
T
F
I
E
S
E
E
G
S
G
R
G
Site 40
S445
F
I
E
S
E
E
G
S
G
R
G
A
A
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation