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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBN1
Full Name:
Fibrillin-1
Alias:
350 kda glycoprotein component extracellular microfibril; FBN; Fibrillin 1; Marfan syndrome; MASS; MFS1; OCTD; SGS; Weill-Marchesani syndrome; WMS
Type:
Extracellular matrix
Mass (Da):
312312
Number AA:
2871
UniProt ID:
P35555
International Prot ID:
IPI00328113
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0005615
GO:0001527
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005201
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007507
GO:0001501
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
N
V
K
E
T
R
A
S
R
A
K
R
R
G
G
Site 2
Y63
P
N
V
C
G
S
R
Y
N
A
Y
C
C
P
G
Site 3
S110
P
S
G
Q
I
A
P
S
C
G
S
R
S
I
Q
Site 4
S115
A
P
S
C
G
S
R
S
I
Q
H
C
N
I
R
Site 5
Y181
G
P
Q
C
E
R
D
Y
R
T
G
P
C
F
T
Site 6
S283
G
H
K
L
N
E
V
S
Q
K
C
E
D
I
D
Site 7
T307
E
G
G
E
C
T
N
T
V
S
S
Y
F
C
K
Site 8
Y311
C
T
N
T
V
S
S
Y
F
C
K
C
P
P
G
Site 9
Y320
C
K
C
P
P
G
F
Y
T
S
P
D
G
T
R
Site 10
S322
C
P
P
G
F
Y
T
S
P
D
G
T
R
C
I
Site 11
T326
F
Y
T
S
P
D
G
T
R
C
I
D
V
R
P
Site 12
Y337
D
V
R
P
G
Y
C
Y
T
A
L
T
N
G
R
Site 13
S346
A
L
T
N
G
R
C
S
N
Q
L
P
Q
S
I
Site 14
T382
E
M
C
P
I
R
A
T
E
D
F
N
K
L
C
Site 15
Y401
V
I
P
G
R
P
E
Y
P
P
P
P
L
G
P
Site 16
Y434
V
P
R
P
P
V
E
Y
L
Y
P
S
R
E
P
Site 17
Y436
R
P
P
V
E
Y
L
Y
P
S
R
E
P
P
R
Site 18
Y458
D
Y
C
Q
L
V
R
Y
L
C
Q
N
G
R
C
Site 19
T468
Q
N
G
R
C
I
P
T
P
G
S
Y
R
C
E
Site 20
Y519
T
C
Q
C
R
A
G
Y
Q
S
T
L
T
R
T
Site 21
S521
Q
C
R
A
G
Y
Q
S
T
L
T
R
T
E
C
Site 22
T522
C
R
A
G
Y
Q
S
T
L
T
R
T
E
C
R
Site 23
S606
K
P
G
F
Q
L
A
S
D
G
R
Y
C
K
D
Site 24
Y610
Q
L
A
S
D
G
R
Y
C
K
D
I
N
E
C
Site 25
Y635
C
V
N
T
D
G
S
Y
R
C
E
C
F
P
G
Site 26
T660
V
D
T
H
M
R
S
T
C
Y
G
G
Y
K
R
Site 27
Y665
R
S
T
C
Y
G
G
Y
K
R
G
Q
C
I
K
Site 28
Y707
P
A
Q
N
S
A
E
Y
Q
A
L
C
S
S
G
Site 29
S713
E
Y
Q
A
L
C
S
S
G
P
G
M
T
S
A
Site 30
S719
S
S
G
P
G
M
T
S
A
G
S
D
I
N
E
Site 31
S722
P
G
M
T
S
A
G
S
D
I
N
E
C
A
L
Site 32
Y746
C
E
N
L
R
G
T
Y
K
C
I
C
N
S
G
Site 33
Y754
K
C
I
C
N
S
G
Y
E
V
D
S
T
G
K
Site 34
S758
N
S
G
Y
E
V
D
S
T
G
K
N
C
V
D
Site 35
T759
S
G
Y
E
V
D
S
T
G
K
N
C
V
D
I
Site 36
T784
D
N
G
Q
C
R
N
T
P
G
S
F
V
C
T
Site 37
Y798
T
C
P
K
G
F
I
Y
K
P
D
L
K
T
C
Site 38
T804
I
Y
K
P
D
L
K
T
C
E
D
I
D
E
C
Site 39
S827
V
C
K
N
S
P
G
S
F
I
C
E
C
S
S
Site 40
S833
G
S
F
I
C
E
C
S
S
E
S
T
L
D
P
Site 41
S834
S
F
I
C
E
C
S
S
E
S
T
L
D
P
T
Site 42
T837
C
E
C
S
S
E
S
T
L
D
P
T
K
T
I
Site 43
T841
S
E
S
T
L
D
P
T
K
T
I
C
I
E
T
Site 44
T843
S
T
L
D
P
T
K
T
I
C
I
E
T
I
K
Site 45
Y900
D
P
I
C
G
K
G
Y
S
R
I
K
G
T
Q
Site 46
T957
C
L
D
I
R
L
E
T
C
F
L
R
Y
E
D
Site 47
T1001
E
E
C
P
M
R
N
T
P
E
Y
E
E
L
C
Site 48
Y1004
P
M
R
N
T
P
E
Y
E
E
L
C
P
R
G
Site 49
S1037
N
E
C
K
M
I
P
S
L
C
T
H
G
K
C
Site 50
S1057
S
F
K
C
R
C
D
S
G
F
A
L
D
S
E
Site 51
S1063
D
S
G
F
A
L
D
S
E
E
R
N
C
T
D
Site 52
T1069
D
S
E
E
R
N
C
T
D
I
D
E
C
R
I
Site 53
S1077
D
I
D
E
C
R
I
S
P
D
L
C
G
R
G
Site 54
T1089
G
R
G
Q
C
V
N
T
P
G
D
F
E
C
K
Site 55
S1103
K
C
D
E
G
Y
E
S
G
F
M
M
M
K
N
Site 56
S1151
H
Q
L
S
P
N
I
S
A
C
I
D
I
N
E
Site 57
Y1186
Q
C
A
C
N
P
G
Y
H
S
T
P
D
R
L
Site 58
T1213
G
G
C
E
T
F
C
T
N
S
E
G
S
Y
E
Site 59
Y1219
C
T
N
S
E
G
S
Y
E
C
S
C
Q
P
G
Site 60
S1222
S
E
G
S
Y
E
C
S
C
Q
P
G
F
A
L
Site 61
S1235
A
L
M
P
D
Q
R
S
C
T
D
I
D
E
C
Site 62
T1237
M
P
D
Q
R
S
C
T
D
I
D
E
C
E
D
Site 63
T1277
M
A
S
E
D
M
K
T
C
V
D
V
N
E
C
Site 64
Y1311
I
C
H
C
D
M
G
Y
S
G
K
K
G
K
T
Site 65
S1351
G
S
F
K
C
S
C
S
P
G
W
I
G
D
G
Site 66
T1362
I
G
D
G
I
K
C
T
D
L
D
E
C
S
N
Site 67
Y1395
R
C
L
C
K
E
G
Y
T
G
D
G
F
T
C
Site 68
T1403
T
G
D
G
F
T
C
T
D
L
D
E
C
S
E
Site 69
Y1476
R
C
E
C
E
I
G
Y
E
L
D
R
S
G
G
Site 70
S1481
I
G
Y
E
L
D
R
S
G
G
N
C
T
D
V
Site 71
T1505
I
S
G
N
C
V
N
T
P
G
S
Y
I
C
D
Site 72
Y1509
C
V
N
T
P
G
S
Y
I
C
D
C
P
P
D
Site 73
T1522
P
D
F
E
L
N
P
T
R
V
G
C
V
D
T
Site 74
T1529
T
R
V
G
C
V
D
T
R
S
G
N
C
Y
L
Site 75
Y1535
D
T
R
S
G
N
C
Y
L
D
I
R
P
R
G
Site 76
T1547
P
R
G
D
N
G
D
T
A
C
S
N
E
I
G
Site 77
S1550
D
N
G
D
T
A
C
S
N
E
I
G
V
G
V
Site 78
S1565
S
K
A
S
C
C
C
S
L
G
K
A
W
G
T
Site 79
T1572
S
L
G
K
A
W
G
T
P
C
E
M
C
P
A
Site 80
Y1585
P
A
V
N
T
S
E
Y
K
I
L
C
P
G
G
Site 81
Y1637
Q
C
R
C
P
T
G
Y
Y
L
N
E
D
T
R
Site 82
T1654
D
D
V
N
E
C
E
T
P
G
I
C
G
P
G
Site 83
Y1664
I
C
G
P
G
T
C
Y
N
T
V
G
N
Y
T
Site 84
Y1678
T
C
I
C
P
P
D
Y
M
Q
V
N
G
G
N
Site 85
Y1696
D
M
R
R
S
L
C
Y
R
N
Y
Y
A
D
N
Site 86
Y1699
R
S
L
C
Y
R
N
Y
Y
A
D
N
Q
T
C
Site 87
Y1700
S
L
C
Y
R
N
Y
Y
A
D
N
Q
T
C
D
Site 88
T1741
E
Q
C
P
I
P
S
T
D
E
F
A
T
L
C
Site 89
T1746
P
S
T
D
E
F
A
T
L
C
G
S
Q
R
P
Site 90
Y1839
R
C
D
C
K
P
G
Y
R
F
T
S
T
G
Q
Site 91
S1843
K
P
G
Y
R
F
T
S
T
G
Q
C
N
D
R
Site 92
T1904
R
D
A
C
G
N
G
T
C
R
N
T
I
G
S
Site 93
T1988
P
R
K
C
A
P
G
T
C
Q
N
L
D
G
S
Site 94
Y1996
C
Q
N
L
D
G
S
Y
R
C
I
C
P
P
G
Site 95
Y2004
R
C
I
C
P
P
G
Y
S
L
Q
N
E
K
C
Site 96
S2045
C
L
C
P
E
G
F
S
L
S
S
S
G
R
R
Site 97
S2047
C
P
E
G
F
S
L
S
S
S
G
R
R
C
Q
Site 98
S2048
P
E
G
F
S
L
S
S
S
G
R
R
C
Q
D
Site 99
S2049
E
G
F
S
L
S
S
S
G
R
R
C
Q
D
L
Site 100
Y2060
C
Q
D
L
R
M
S
Y
C
Y
A
K
F
E
G
Site 101
Y2062
D
L
R
M
S
Y
C
Y
A
K
F
E
G
G
K
Site 102
S2071
K
F
E
G
G
K
C
S
S
P
K
S
R
N
H
Site 103
S2072
F
E
G
G
K
C
S
S
P
K
S
R
N
H
S
Site 104
S2075
G
K
C
S
S
P
K
S
R
N
H
S
K
Q
E
Site 105
S2079
S
P
K
S
R
N
H
S
K
Q
E
C
C
C
A
Site 106
T2101
D
P
C
E
L
C
P
T
E
P
D
E
A
F
R
Site 107
Y2149
C
I
N
T
D
G
S
Y
R
C
E
C
P
F
G
Site 108
T2167
A
G
N
E
C
V
D
T
D
E
C
S
V
G
N
Site 109
Y2225
A
F
R
C
V
N
T
Y
G
S
Y
E
C
K
C
Site 110
Y2228
C
V
N
T
Y
G
S
Y
E
C
K
C
P
V
G
Site 111
Y2236
E
C
K
C
P
V
G
Y
V
L
R
E
D
R
R
Site 112
Y2280
M
C
I
C
G
P
G
Y
Q
R
R
P
D
G
E
Site 113
Y2314
C
L
N
T
R
G
S
Y
T
C
E
C
N
D
G
Site 114
S2325
C
N
D
G
F
T
A
S
P
N
Q
D
E
C
L
Site 115
Y2338
C
L
D
N
R
E
G
Y
C
F
T
E
V
L
Q
Site 116
T2359
S
S
N
R
N
P
V
T
K
S
E
C
C
C
D
Site 117
Y2425
C
V
N
D
R
G
S
Y
H
C
I
C
K
T
G
Site 118
Y2433
H
C
I
C
K
T
G
Y
T
P
D
I
T
G
T
Site 119
T2434
C
I
C
K
T
G
Y
T
P
D
I
T
G
T
S
Site 120
T2438
T
G
Y
T
P
D
I
T
G
T
S
C
V
D
L
Site 121
S2441
T
P
D
I
T
G
T
S
C
V
D
L
N
E
C
Site 122
Y2466
C
K
N
T
E
G
S
Y
Q
C
S
C
P
K
G
Site 123
S2482
I
L
Q
E
D
G
R
S
C
K
D
L
D
E
C
Site 124
T2544
S
K
G
I
C
Q
N
T
P
G
S
F
T
C
E
Site 125
S2557
C
E
C
Q
R
G
F
S
L
D
Q
T
G
S
S
Site 126
T2561
R
G
F
S
L
D
Q
T
G
S
S
C
E
D
V
Site 127
S2563
F
S
L
D
Q
T
G
S
S
C
E
D
V
D
E
Site 128
S2564
S
L
D
Q
T
G
S
S
C
E
D
V
D
E
C
Site 129
Y2629
C
H
N
T
L
G
S
Y
K
C
M
C
P
A
G
Site 130
Y2639
M
C
P
A
G
F
Q
Y
E
Q
F
S
G
G
C
Site 131
S2660
G
S
A
Q
A
P
C
S
Y
G
C
S
N
T
E
Site 132
Y2661
S
A
Q
A
P
C
S
Y
G
C
S
N
T
E
G
Site 133
S2664
A
P
C
S
Y
G
C
S
N
T
E
G
G
Y
L
Site 134
Y2670
C
S
N
T
E
G
G
Y
L
C
G
C
P
P
G
Site 135
Y2678
L
C
G
C
P
P
G
Y
F
R
I
G
Q
G
H
Site 136
S2702
G
N
P
E
P
P
V
S
G
E
M
D
D
N
S
Site 137
S2709
S
G
E
M
D
D
N
S
L
S
P
E
A
C
Y
Site 138
S2711
E
M
D
D
N
S
L
S
P
E
A
C
Y
E
C
Site 139
Y2716
S
L
S
P
E
A
C
Y
E
C
K
I
N
G
Y
Site 140
Y2723
Y
E
C
K
I
N
G
Y
P
K
R
G
R
K
R
Site 141
S2732
K
R
G
R
K
R
R
S
T
N
E
T
D
A
S
Site 142
T2733
R
G
R
K
R
R
S
T
N
E
T
D
A
S
N
Site 143
T2736
K
R
R
S
T
N
E
T
D
A
S
N
I
E
D
Site 144
S2739
S
T
N
E
T
D
A
S
N
I
E
D
Q
S
E
Site 145
S2752
S
E
T
E
A
N
V
S
L
A
S
W
D
V
E
Site 146
T2786
E
L
L
P
A
L
T
T
L
T
N
H
N
R
Y
Site 147
T2788
L
P
A
L
T
T
L
T
N
H
N
R
Y
L
I
Site 148
Y2793
T
L
T
N
H
N
R
Y
L
I
E
S
G
N
E
Site 149
S2813
I
N
Q
K
E
G
I
S
Y
L
H
F
T
K
K
Site 150
Y2814
N
Q
K
E
G
I
S
Y
L
H
F
T
K
K
K
Site 151
T2826
K
K
K
P
V
A
G
T
Y
S
L
Q
I
S
S
Site 152
Y2827
K
K
P
V
A
G
T
Y
S
L
Q
I
S
S
T
Site 153
S2828
K
P
V
A
G
T
Y
S
L
Q
I
S
S
T
P
Site 154
S2832
G
T
Y
S
L
Q
I
S
S
T
P
L
Y
K
K
Site 155
T2834
Y
S
L
Q
I
S
S
T
P
L
Y
K
K
K
E
Site 156
Y2837
Q
I
S
S
T
P
L
Y
K
K
K
E
L
N
Q
Site 157
Y2849
L
N
Q
L
E
D
K
Y
D
K
D
Y
L
S
G
Site 158
Y2853
E
D
K
Y
D
K
D
Y
L
S
G
E
L
G
D
Site 159
S2855
K
Y
D
K
D
Y
L
S
G
E
L
G
D
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation